Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mark L. Weber"'
Autor:
Wei Chou Tseng, Veronica Reinhart, Thomas A. Lanz, Mark L. Weber, Jincheng Pang, Kevin Xuong Vinh Le, Robert D. Bell, Patricio O’Donnell, Derek L. Buhl
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Schizophrenia is a complex and heterogenous disease that presents with abnormalities in glutamate signaling and altered immune and inflammatory signals. Genome-wide association studies have indicated specific genes and pathways that may cont
Externí odkaz:
https://doaj.org/article/78b4111fc55c48a39108af05d438929d
Autor:
Derek L. Buhl, Wei Chou Tseng, Veronica Reinhart, Mark L. Weber, Kevin Xuong Vinh Le, Jincheng Pang, Robert D. Bell, Patricio O'Donnell, Thomas A. Lanz
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Translational Psychiatry
Translational Psychiatry
Schizophrenia is a complex and heterogenous disease that presents with abnormalities in glutamate signaling and altered immune and inflammatory signals. Genome-wide association studies have indicated specific genes and pathways that may contribute to
Autor:
Ludivine Moine, Bruce N. Rogers, Mark L. Weber, Karen Tse, Sheri L. Snow, Susan E. Drozda, Karen Baker, John A. Lowe, Kevin A. Serpa, Katherine Schuyten, Jennifer E. Davoren, Rong Suobao, Ann S. Wright, Shari L. DeNinno, Michelle Marie Claffey, Allen J. Duplantier, Christopher Ryan Butler, Brian P. Boscoe, Alan J. Clark, Polina Stolyar, Robert J. Mather, Lois K. Chenard, Haojing Rong, Gaurav Arora, Matthew R. Reese, Tammy Whisman, Lei Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4941-4944
Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures. In an effort to identify a compound with suc
Autor:
Patricio O'Donnell, Jonathan Garst-Orozco, Derek L. Buhl, David A. Lewis, Vikaas S. Sohal, Hualin Xi, Dominique Arion, Mark L. Weber, John F. Enwright, Ruchi Malik, Thomas A. Lanz
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0233895 (2020)
PLoS ONE, Vol 15, Iss 6, p e0233895 (2020)
Deficits in fast-spiking inhibitory interneurons (FSINs) within the dorsolateral prefrontal cortex (dlPFC) are hypothesized to underlie cognitive impairment associated with schizophrenia. Though representing a minority of interneurons, this key cell
Autor:
Jason K. Dutra, Christopher W. am Ende, Derek L. Buhl, Katherine Hales, Wei Chou Tseng, Dmitri Volfson, Jincheng Pang, Luke Joseph Bogart, Michael Eric Green, Mark L. Weber, Christopher L. Shaffer
Publikováno v:
Neuropharmacology. 153
Ketamine is a rapid-onset antidepressant whose efficacy long outlasts its pharmacokinetics. Multiple studies suggest ketamine's antidepressant effects require increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-dependent
Autor:
Raymond S. Hurst, Nandini Chaturbhai Patel, Dina McGinnis, Xinjun J. Hou, Mihály Hajós, Dianne K. Bryce, Cheng Chang, Christopher J. O’Donnell, JianHua Liu, William E. Hoffmann, Patricia A. Seymour, Laigao Chen, Renato J. Scialis, Yunjing Wei, Karki Kapil Kumar, R. Scott Obach, Longfei Xie, Jacob Bradley Schwarz, John T. Lazzaro, Kenneth R. Zasadny, Sarah M. Osgood, Christopher J. Schmidt, Christopher L. Shaffer, Jayvardhan Pandit, Susan M. Lotarski, Mark L. Weber
Publikováno v:
Journal of medicinal chemistry. 58(10)
A unique tetrahydrofuran ether class of highly potent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor potentiators has been identified using rational and structure-based drug design. An acyclic lead compound, containing an ether-linked
Autor:
Thomas G. Heffner, Jack J. Kinsora, Jacob Bradley Schwarz, Ti Zhi-Su, David J. Wustrow, Leonard T. Meltzer, Thomas Richard Belliotti, Thomas Capiris, Andrew John Thorpe, Lawrence D. Wise, Mark L. Weber, Charles Taylor, Mark J. Field, Mark G. Vartanian, I.Victor Ekhato
Publikováno v:
Journal of Medicinal Chemistry. 48:2294-2307
Pregabalin exhibits robust activity in preclinical assays indicative of potential antiepileptic, anxiolytic, and antihyperalgesic clinical efficacy. It binds with high affinity to the alpha(2)-delta subunit of voltage-gated calcium channels and is a
Autor:
Christopher J. Schmidt, Frank S. Menniti, Christopher L. Shaffer, Ashley N. Hanks, John T. Lazzaro, JianHua Liu, Renato J. Scialis, Dianne K. Bryce, Susan M. Lotarski, Sarah M. Osgood, Raymond S. Hurst, Mark L. Weber, Mihály Hajós, William E. Hoffmann
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 347(1)
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) positive allosteric modulation (i.e., "potentiation") has been proposed to overcome cognitive impairments in schizophrenia, but AMPAR overstimulation can be excitotoxic. Thus, it
Autor:
Raymond S. Hurst, Corry M. Hofland, Gunnar Flik, Hans Rollema, Christopher L. Shaffer, Mark L. Weber, Thomas I. F. H. Cremers
Publikováno v:
Neuropharmacology. 72
Inhibition of central α4β2 nAChRs by antidepressants, proposed to contribute to their clinical efficacy, was assessed for monoamine reuptake inhibitors (amitriptyline, nortriptyline, fluoxetine, sertraline, paroxetine, citalopram) by comparing proj
Publikováno v:
Journal of Neuroscience Methods. 59:121-128
We evaluated concentrations of excitatory amino acids released from slices into the superfusing solution and also evaluated extracellular field potential recordings and histological appearance of slice tissues to evaluate several sodium-channel modul