Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Mark L. Tykocinski"'
Autor:
Michal Dranitzki Elhalel, Mark L. Tykocinski, Noam Shani, Fanny Shkedy, Jitka Yehudith Sagiv, Liat Ben Gigi–Tamir, Yosi Meir Gozlan, Kobi Tzdaka, Tatyana B. Prigozhina, Alexandra Aronin, Shira Amsili, Efi Makdasi
Cytotoxic T-lymphocyte antigen 4 (CTLA4)-FasL, a homo-hexameric signal converter protein, is capable of inducing robust apoptosis in malignant cells of the B-cell lineage expressing its cognate B7 and Fas targets, while sparing nonmalignant ones. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8acdcf063baf664e37a78b4888b1cb1
https://doi.org/10.1158/1535-7163.c.6542272.v1
https://doi.org/10.1158/1535-7163.c.6542272.v1
Autor:
Michal Dranitzki Elhalel, Mark L. Tykocinski, Noam Shani, Fanny Shkedy, Jitka Yehudith Sagiv, Liat Ben Gigi–Tamir, Yosi Meir Gozlan, Kobi Tzdaka, Tatyana B. Prigozhina, Alexandra Aronin, Shira Amsili, Efi Makdasi
(a) Receptors expression on human cell lines and mouse BCL-1 splenocytes. (b) Anti CTLA4-FasL antibodies are formed in treated mice. (c) Neutralizing anti CTLA4-FasL antibodies are formed in treated mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b964846c2e67de8d26eac159f86a21bb
https://doi.org/10.1158/1535-7163.22519081.v1
https://doi.org/10.1158/1535-7163.22519081.v1
Autor:
Jonathan R. Brody, Mark L. Tykocinski, Rajanikanth Vadigepalli, Charles J. Yeo, Nicole Meisner-Kober, Jonathan N. Sachs, Janet A. Sawicki, Jordan M. Winter, Angie D. Lobo, Saswati N. Chand, Danielle DeCicco, Mahsa Zarei, Matthew C. Weber, Carmella Romeo
Supplemental Figure Images
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0eb329b7ad88b1e22c594b46622ee1
https://doi.org/10.1158/1541-7786.22511716
https://doi.org/10.1158/1541-7786.22511716
Autor:
Jonathan R. Brody, Mark L. Tykocinski, Rajanikanth Vadigepalli, Charles J. Yeo, Nicole Meisner-Kober, Jonathan N. Sachs, Janet A. Sawicki, Jordan M. Winter, Angie D. Lobo, Saswati N. Chand, Danielle DeCicco, Mahsa Zarei, Matthew C. Weber, Carmella Romeo
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal cancers, in part, due to resistance to both conventional and targeted therapeutics. TRAIL directly induces apoptosis through engagement of cell surface Death Receptors (DR4 and DR5), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34413c451ad46f9bdc5d759366dc3e0d
https://doi.org/10.1158/1541-7786.c.6540022.v1
https://doi.org/10.1158/1541-7786.c.6540022.v1
Autor:
Michal Dranitzki Elhalel, Mark L. Tykocinski, Noam Shani, Fanny Shkedy, Jitka Yehudith Sagiv, Liat Ben Gigi–Tamir, Yosi Meir Gozlan, Kobi Tzdaka, Tatyana B. Prigozhina, Alexandra Aronin, Shira Amsili, Efi Makdasi
Table S1. Summary of the Toxicokinetic Parameters of CTLA4-FasL in mouse Plasma at the first injection (Day 1) and the third injection (Day 5) Table S2. Summary of the Pharmacokinetic parameters in a single dose of CTLA4-FasL in Cynomolgus monkey pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c90efa3cfd76a11505c99d79171c4e
https://doi.org/10.1158/1535-7163.22519057.v1
https://doi.org/10.1158/1535-7163.22519057.v1
Autor:
Michal Dranitzki Elhalel, Mark L. Tykocinski, Noam Shani, Fanny Shkedy, Jitka Yehudith Sagiv, Liat Ben Gigi–Tamir, Yosi Meir Gozlan, Kobi Tzdaka, Tatyana B. Prigozhina, Alexandra Aronin, Shira Amsili, Efi Makdasi
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1700b3bdd4de82a3cc3d1d6b0fa0dc1e
https://doi.org/10.1158/1535-7163.22519060.v1
https://doi.org/10.1158/1535-7163.22519060.v1
Autor:
Jonathan R. Brody, Mark L. Tykocinski, Rajanikanth Vadigepalli, Charles J. Yeo, Nicole Meisner-Kober, Jonathan N. Sachs, Janet A. Sawicki, Jordan M. Winter, Angie D. Lobo, Saswati N. Chand, Danielle DeCicco, Mahsa Zarei, Matthew C. Weber, Carmella Romeo
Supplemental Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd335ede44214512d502d655f8c375f
https://doi.org/10.1158/1541-7786.22511713
https://doi.org/10.1158/1541-7786.22511713
Autor:
Matthew P. Weber, Elina Zorde-Khvalevsky, Amnon Peled, Adam Foley-Comer, Ami Tamir, Ayelet Chajut, Lucy Ganthous, Alexandra Aronin, Rinat Tabakman, Shirley Greenwald, Jasmine Avichzer, Roy Kahn, Mark L. Tykocinski, Iris Pecker, Liat Ben Gigi Tamir, Michal Michal Elhalel Dranitzki
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundTIGIT, an inhibitory immune checkpoint, is a target of interest for immuno-oncology combination therapies. TIGIT is part of a complex molecular network containing four receptors (DNAM1, TIGIT, PVRIG and CD96) and two ligands (PVR and PVRL2)
Autor:
Mark L. Tykocinski, Salvatore Mangione
Publikováno v:
The New England journal of medicine. 385(4)
Virchow at 200 and Lown at 100 The Covid-19 pandemic has forced many people to reconsider what medicine is all about. But debate over what doctoring is — and what it is not — is nothing new, and 20...
Autor:
Mark L, Tykocinski
Publikováno v:
Academic Pathology. 9:100044