Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mark L. Stamper"'
Autor:
John W. Lampe, Christopher T. Lowden, G. Erik Jagdmann, Frederick R. Hubbard, Hong Hu, Mary George Johnson, Michael Patrick Lynch, Lawrence Michael Ballas, Sean P. Hollinshead, Steven E. Hall, Julia Marie Heerding, Jean Marie Defauw, Jose S. Mendoza, Marcia M. Murphy, Christopher K. Biggers, Joseph W. Wilson, Kiyomi Carter, Robert J. Foglesong, Jefferson E. Davis, Philip F. Hughes, Yen-Shi Lai, Mark L. Stamper, James W. Darges
Publikováno v:
Journal of Medicinal Chemistry. 45:2624-2643
A series of analogues of the protein kinase C (PKC) inhibitory natural product balanol which bear modified benzophenone subunits are described. The analogues were designed with the goal of uncovering structure-activity features that could be used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b848f26ec9d5d2fbf8c1b1cafa0ef593
https://doi.org/10.1021/jm020018f
https://doi.org/10.1021/jm020018f
Autor:
Mark L. Stamper, Yen-Shi Lai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2147-2150
Analogs 2–5 of balanol (−)- 1 , a potent protein kinase C (PKC) inhibitor, were prepared in which the perhydroazepine N atom was replaced with O, S, or C. Compounds 2 and 3 are found to show enhanced isozyme selectivity, despite the general trend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c30f8f5d8b8b4bbe971b2fbd26f9289b
https://doi.org/10.1016/0960-894x(95)00364-y
https://doi.org/10.1016/0960-894x(95)00364-y
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1839-1842
A variety of balanol analogs bearing carboxylic acid replacements (amides, sulfonamides and tetrazoles) were synthesized and evaluated for protein kinase C (PKC) inhibitory activity. In general, those compounds which bear an acidic proton (pKa ≤ 7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69311df84b48fc3b4457ed3ecb02fd6c
https://doi.org/10.1016/0960-894x(95)00303-b
https://doi.org/10.1016/0960-894x(95)00303-b
Autor:
Samir Dandakar, Frederick R. Hubbard, Thomas G. Bbrand, Mark L. Stamper, Mike Brown, Kiyomi Kalter
Publikováno v:
SLAS Discovery. 3:63-65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4603b2659ffcb0c0cfb21a1fb77e6e29
https://doi.org/10.1177/108705719800300109
https://doi.org/10.1177/108705719800300109