Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mark L. Sowers"'
Autor:
Kangling Zhang, Mark L. Sowers, Ellie I. Cherryhomes, Vipul K. Singh, Abhishek Mishra, Blanca I. Restrepo, Arshad Khan, Chinnaswamy Jagannath
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Macrophages are the preeminent phagocytic cells which control multiple infections. Tuberculosis a leading cause of death in mankind and the causative organism Mycobacterium tuberculosis (MTB) infects and persists in macrophages. Macrophages use react
Externí odkaz:
https://doaj.org/article/430127cf2afd426fafd65b8cca7fff42
Autor:
James W. Conrad, Mark L. Sowers, Dianne Y. Yap, Ellie Cherryhomes, B. Montgomery Pettitt, Kamil Khanipov, Lawrence C. Sowers
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1308 (2023)
Increased expression of the human telomere reverse transcriptase (hTERT) in tumors promotes tumor cell survival and diminishes the survival of patients. Cytosine-to-thymine (C-to-T) transition mutations (C250T or C228T) in the hTERT promoter create b
Externí odkaz:
https://doaj.org/article/4bc5f189d353409db9ab8edea379c2ed
Autor:
Tuvshintugs Baljinnyam, Mark L. Sowers, Chia Wei Hsu, James W. Conrad, Jason L. Herring, Linda C. Hackfeld, Lawrence C. Sowers
Publikováno v:
PLoS ONE, Vol 17, Iss 8 (2022)
The DNA of all living organisms is persistently damaged by endogenous reactions including deamination and oxidation. Such damage, if not repaired correctly, can result in mutations that drive tumor development. In addition to chemical damage, recent
Externí odkaz:
https://doaj.org/article/86c08afd0f114ea2a8e78c2cf701751c
Autor:
Mark L. Sowers, James W. Conrad, Bruce Chang-Gu, Ellie Cherryhomes, Linda C. Hackfeld, Lawrence C. Sowers
Publikováno v:
Molecules, Vol 28, Iss 3, p 970 (2023)
Although genomic DNA is predominantly duplex under physiological conditions, particular sequence motifs can favor the formation of alternative secondary structures, including the G-quadruplex. These structures can exist within gene promoters, telomer
Externí odkaz:
https://doaj.org/article/a33412c3fbe443a6b6675c6400251f67
Autor:
James L. Sowers, Mark L. Sowers, Alexander S. Shavkunov, Bridget E. Hawkins, Ping Wu, Douglas S. DeWitt, Donald S. Prough, Kangling Zhang
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103108- (2021)
Summary: The release of excess glutamate following traumatic brain injury (TBI) results in glutamate excitotoxicity and metabolic energy failure. Endogenous mechanisms for reducing glutamate concentration in the brain parenchyma following TBI are poo
Externí odkaz:
https://doaj.org/article/ecf19e6a96b14dc49a8fb377e9d5d3fb
Autor:
Mark L. Sowers, Jessica Di Re, Paul A. Wadsworth, Alexander S. Shavkunov, Cheryl Lichti, Kangling Zhang, Fernanda Laezza
Publikováno v:
Proteomes, Vol 7, Iss 1, p 5 (2019)
Fibroblast growth factor 14 (FGF14) is a member of the intracellular FGFs, which is a group of proteins involved in neuronal ion channel regulation and synaptic transmission. We previously demonstrated that male Fgf14−/− mice recapitulate the sal
Externí odkaz:
https://doaj.org/article/57c1b2e5666345158fce937f9d31edad
Autor:
Tuvshintugs Baljinnyam, James W. Conrad, Mark L. Sowers, Bruce Chang-Gu, Jason L. Herring, Linda C. Hackfeld, Kangling Zhang, Lawrence C. Sowers
Publikováno v:
Chemical Research in Toxicology. 36:162-176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f8a28e36166a66dd4aec39d958cea6
https://doi.org/10.1021/acs.chemrestox.2c00172
https://doi.org/10.1021/acs.chemrestox.2c00172
Autor:
Chia Wei Hsu, James W Conrad, Mark L Sowers, Tuvshintugs Baljinnyam, Jason L Herring, Linda C Hackfeld, Sandra S Hatch, Lawrence C Sowers
Publikováno v:
Nucleic acids research. 50(13)
DNA damage drives genetic mutations that underlie the development of cancer in humans. Multiple pathways have been described in mammalian cells which can repair this damage. However, most work to date has focused upon single lesions in DNA. We presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658aab208876de945c45a29a394a5078
https://pubmed.ncbi.nlm.nih.gov/35776119
https://pubmed.ncbi.nlm.nih.gov/35776119
Autor:
Mark L. Sowers, Lawrence C. Sowers
Publikováno v:
International journal of molecular sciences. 23(13)
Glioblastoma is a fatal brain tumor with a bleak prognosis. The use of chemotherapy, primarily the alkylating agent temozolomide, coupled with radiation and surgical resection, has provided some benefit. Despite this multipronged approach, average pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b600c2af1152cd69ad2fbfc837e8d174
https://pubmed.ncbi.nlm.nih.gov/35806160
https://pubmed.ncbi.nlm.nih.gov/35806160
Autor:
Chia Wei Hsu, Mark L. Sowers, Tuvshintugs Baljinnyam, Jason L. Herring, Linda C. Hackfeld, Hui Tang, Kangling Zhang, Lawrence C. Sowers
Publikováno v:
The Journal of biological chemistry. 298(3)
The hydrolytic deamination of cytosine and 5-methylcytosine drives many of the transition mutations observed in human cancer. The deamination-induced mutagenic intermediates include either uracil or thymine adducts mispaired with guanine. While a sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9721af22ba81f988434f672c20ae962
https://pubmed.ncbi.nlm.nih.gov/35085553
https://pubmed.ncbi.nlm.nih.gov/35085553