Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mark L. Sandberg"'
Autor:
Alexander C. Partin, Richele Bruno, Sanam Shafaattalab, Erica Vander Mause, Aaron Winters, Mark Daris, Casey Gahrs, Claudia A. Jette, Breanna DiAndreth, Mark L. Sandberg, Agnes E. Hamburger, Alexander Kamb, Timothy P. Riley
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Clinical applications of CAR-T cells are limited by the scarcity of tumor-specific targets and are often afflicted with the same on-target/off-tumor toxicities that plague other cancer treatments. A new promising strategy to enforce tumor selectivity
Externí odkaz:
https://doaj.org/article/1abd20696ac94401a8c73d1ce3e8cc8d
Autor:
Mark L. Sandberg, Yuta Ando, Alexander Kamb, Ming-Lun Wu, Kathleen R Negri, Wen-Hua Lee, Julyun Oh, Xueyin Wang, Michele McElvain, Grant B Gabrelow, Aaron D. Martin, Han Xu, Dora Toledo Warshaviak
Publikováno v:
Molecular Immunology. 138:137-149
Though TCRs have been subject to limited engineering in the context of therapeutic design and optimization, they are used largely as found in nature. On the other hand, CARs are artificial, composed of different segments of proteins that function in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bcb9b9ce61be550447434fcd7685e5
https://doi.org/10.1016/j.molimm.2021.07.018
https://doi.org/10.1016/j.molimm.2021.07.018
Autor:
Kathleen R Negri, Xueyin Wang, Han Xu, Mark E. Daris, Aaron D. Martin, Craig Pigott, Falene Chai, Christine Yao, Ming-Lun Wu, James Furney, Dora Toledo Warshaviak, Grant B Gabrelow, Daniel P Nampe, Mark L. Sandberg, Alexander Kamb, Wen-Hua Lee, Julyun Oh, Michele McElvain
Publikováno v:
Journal of Immunotherapy (Hagerstown, Md. : 1997)
Supplemental Digital Content is available in the text.
Next-generation T-cell therapies will likely continue to utilize T-cell receptors (TCRs) and chimeric antigen receptors (CARs) because each receptor type has advantages. TCRs often possess e
Next-generation T-cell therapies will likely continue to utilize T-cell receptors (TCRs) and chimeric antigen receptors (CARs) because each receptor type has advantages. TCRs often possess e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e3504edfa67b79441c42b612780e76
https://doi.org/10.1097/cji.0000000000000386
https://doi.org/10.1097/cji.0000000000000386
Autor:
Mark L. Sandberg, Xueyin Wang, Aaron D. Martin, Daniel P. Nampe, Grant B. Gabrelow, Chuck Z. Li, Michele E. McElvain, Wen-Hua Lee, Sanam Shafaattalab, Sara Martire, Fernando A. Fisher, Yuta Ando, Edwin Liu, David Ju, Lu Min Wong, Han Xu, Alexander Kamb
Publikováno v:
Science Translational Medicine. 14
TheCEACAM5gene product [carcinoembryonic antigen (CEA)] is an attractive target for colorectal cancer because of its high expression in virtually all colorectal tumors and limited expression in most healthy adult tissues. However, highly active CEA-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b937aafb9e034f95524df0c50694f753
https://doi.org/10.1126/scitranslmed.abm0306
https://doi.org/10.1126/scitranslmed.abm0306
Autor:
Andrew T Miller, Carol Dahlberg, Mark L Sandberg, Ben G Wen, Daniel R Beisner, John A H Hoerter, Albert Parker, Christian Schmedt, Monique Stinson, Jacqueline Avis, Cynthia Cienfuegos, Mark McPate, Pamela Tranter, Martin Gosling, Paul J Groot-Kormelink, Janet Dawson, Shifeng Pan, Shin-Shay Tian, H Martin Seidel, Michael P Cooke
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131071 (2015)
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inosi
Externí odkaz:
https://doaj.org/article/60911ac9821349a2a5779985bf95458d
Autor:
Aaron D. Martin, Mark L. Sandberg, Grant B Gabrelow, Alexander Kamb, Xueyin Wang, Bella Lee, Ming Wu, Mark E. Daris, Han Xu, Michele McElvain, Dora Toledo Warshaviak, Kathleen R Negri
Publikováno v:
Regular and young investigator award abstracts.
Background Recurrent cancer-specific targets are rare. Given the pace of genomic research over the past three decades, few are likely to lie yet undiscovered. In 2013 an innovative MAGE-A3-directed cancer therapeutic of great potential value was term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f870ae276c543c1601545c8e5e0db7b
https://doi.org/10.1136/jitc-2020-sitc2020.0125
https://doi.org/10.1136/jitc-2020-sitc2020.0125
Autor:
Han Xu, Talar Tokatlian, Jee-Young Mock, Mark L. Sandberg, Grant B Gabrelow, Mark E. Daris, Ming Lun Wu, Agnes E. Hamburger, Daniel P Nampe, Aaron D. Martin, Julyun Oh, Michele McElvain, Alexander Kamb, Kathleen R Negri, Xueyin Wang, Grace E. Asuelime
Publikováno v:
Molecular immunology. 126
Chimeric antigen receptors (CARs) and their parent signaling molecule, the T cell receptor (TCR), are fascinating proteins of increasing relevance to disease therapy. Here we use a collection of 1221 pMHC-directed CAR constructs representing 10 pMHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce23fc0d703e573a2920265dea89c53
https://pubmed.ncbi.nlm.nih.gov/32768859
https://pubmed.ncbi.nlm.nih.gov/32768859
Autor:
Han Xu, Mark L. Sandberg, Nimalan Thavandiran, Mohsen Afshar Bakooshli, George Graham, Philip Tagari, Milica Radisic, Andrew B.J. Prowse, Samuel McEwen, Michele McElvain, Hon Le, Andreea Norman, Erik Chau, Christopher M. Hale, Alec D. Witty, Van T. H. Do, Mark Gagliardi, Penney M. Gilbert, Patrick H. Blit, Bo Sun, Peter W. Zandstra, Joel Ostblom, Ian Fernandes, Gordon Keller
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
To accelerate the cardiac drug discovery pipeline, we set out to develop a platform that would be capable of quantifying tissue-level functions such as contractile force and be amenable to standard multiwell-plate manipulations. We report a 96-well-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27a84b32deccbdf437c193f233a617f
https://doi.org/10.1038/s41598-020-62955-3
https://doi.org/10.1038/s41598-020-62955-3
Autor:
Maria Imun, Mark L. Sandberg, Yuta Ando, Wen-Hua Lee, Xueyin Wang, Fernando Fisher, Michele McElvain, Kiran Deshmukh, Agnes E. Hamburger, Han Xu, Lu-Min Wong, Chuck Li, Breanna DiAndreth, Alexander Kamb, David M.C. Ju, Grant B Gabrelow, Dora Toledo-Warshaviak, Sanam Shafaattalab, Daniel P Nampe, Talar Tokatlian, Mark E. Daris, Shruti Sharma, Edwin Liu, Jee-Young Mock, Martin S. Naradikian, Kristian Bolanos-Ibarra, Aaron D. Martin, Grace E. Asuelime
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A131-A131
BackgroundMesothelin (MSLN) and carcinoembryonic antigen (CEA) are classic tumor-associated antigens that are expressed in many solid tumors including the majority of lung, colorectal and pancreatic cancers. However, both MSLN and CEA are also expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::210c828c83b6d00261fd0c8831789f2c
https://doi.org/10.1136/jitc-2021-sitc2021.122
https://doi.org/10.1136/jitc-2021-sitc2021.122
Autor:
Michele McElvain, Mark Gagliardi, Alykhan Motani, Hugo M. Vargas, Bo Sun, Samuel McEwen, Penney M. Gilbert, Jeff D. Reagan, Mark L. Sandberg, Milica Radisic, Han Xu, Peter W. Zandstra, May Mcintosh, Dana Nojima, Mohsen Afshar Bakooshli, Patrick H. Blit, Philip Tagari, Alec D. Witty, Joel Ostblom, Gordon Keller, Nimalan Thavandiran, Andrew B.J. Prowse, Ian Fernandes, George Graham, Erik Chau, Yusheng Qu, Christopher M. Hale, Hon Le
To accelerate the cardiac drug discovery pipeline, we set out to develop a platform that would be amenable to standard multiwell-plate manipulations and be capable of quantifying tissue-level functions such as contractile force. We report a 96-well-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb2650757d9b872a3374f0e5adf5732
