Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Mark L. Richards"'
1
Substituted 2-phenyl-benzimidazole derivatives: novel compounds that suppress key markers of allergy
Autor: Shirley Cruz Lio, Mark Tanji, Anjana Sinha, Jagadish C. Sircar, Major Michael W, Homayon Banie, Thomas Richard J, Mark L. Richards
Publikováno v: European Journal of Medicinal Chemistry. 41:950-969
The pharmacotherapy of allergy and asthma has traditionally focused on the effecter molecules of the allergic cascade, while neglecting targets that play an early role in their development. Reasoning that IgE is central to the expansion of atopic dis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ef3fffe87651a28d07ba2587a8100b
https://doi.org/10.1016/j.ejmech.2006.03.014
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2
mRNA Variants Encoding Multiple Forms of the High-Affinity IgE Receptor Alpha Subunit in Transformed and Nontransformed Mast Cells
Autor: Fu-Tong Liu, Virginia S. Mehl, Mark L. Richards, Michael W. Robertson
Publikováno v: International Archives of Allergy and Immunology. 96:289-295
Multiple mRNA species encoding several predicted forms of the high-affinity IgE receptor alpha subunit (Fc epsilon RI-alpha) have been previously characterized from rat basophilic leukemia cells. Using the polymerase chain reaction procedure, we have
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc7c24c379a085543556cdb55fa9fcc
https://doi.org/10.1159/000235511
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4
2-phenylimidazopyridines, a new series of Golgi compounds with potent antiviral activity
Autor: Homayon Banie, Anjana Sinha, Jagadish C. Sircar, Mark L. Richards, Thomas Richard J
Publikováno v: Journal of medicinal chemistry. 50(24)
Drugs targeted to viral proteins are highly vulnerable to the development of resistant strains. We previously characterized a group of 2-phenylbenzimidazole compounds for their activity against allergy and asthma and more recently established the Gol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd35f7bc1e891e5ffe985e4073c894b
https://pubmed.ncbi.nlm.nih.gov/17973358
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5
Disruption of Golgi processing by 2-phenyl benzimidazole analogs blocks cell proliferation and slows tumor growth
Autor: Arka Chatterjee, Diane Millis, Shirley Cruz Lio, Jagadish C. Sircar, Anjana Sinha, Jessica Johnson, Jeffrey W. Ludwig, Mark L. Richards, Homayon Banie
Publikováno v: Cancer chemotherapy and pharmacology. 61(6)
Cancer chemotherapy continues to be challenged by the emergence of resistant tumors, and one organelle entwined in the development of drug resistance is the Golgi apparatus. Recently, we discovered a group of 2-(substituted phenyl)-benzimidazole (2-P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459660b7f0751d54d57c6f251ccc749e
https://pubmed.ncbi.nlm.nih.gov/17690881
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6
Targeting the secretory pathway for anti-inflammatory drug development
Autor: Mark L. Richards, Jeffrey W. Ludwig
Publikováno v: Current topics in medicinal chemistry. 6(2)
Inflammatory diseases are a complex group of disorders involving multiple levels of the immune system and as such present a daunting challenge to understand and treat. Contemporary drug development targets individual cytokines, chemokines, and recept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0127ff1f2eec8cc4d9f73d55e577128e
https://pubmed.ncbi.nlm.nih.gov/16454765
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8
Novel 2-(substituted phenyl)benzimidazole derivatives with potent activity against IgE, cytokines, and CD23 for the treatment of allergy and asthma
Autor: Anjana Sinha, Mark L. Richards, Shirley Cruz Lio, Jagadish C. Sircar, Kenneth K Tieu
Publikováno v: Journal of medicinal chemistry. 47(26)
The effectiveness of the injectable anti-IgE antibody omalizumab has validated IgE as an important target for allergic diseases, thus spawning the development of small-molecule IgE inhibitors. Herein, a brief SAR is described for novel phenylbenzimid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46efd18bc7ffd9594e9b142b007d9ca6
https://pubmed.ncbi.nlm.nih.gov/15588078
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9
High levels of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor mRNA expression in primary and tumor lymphoid cells
Autor: Dawn T. Bravo, James A. Waschek, Mark L. Richards
Publikováno v: Regulatory peptides. 60(2-3)
Neuropeptides exert a variety of putative immunomodulatory actions. Despite the molecular cloning of multiple forms of receptors for several neuropeptides with putative immunomodulatory effects, including vasoactive intestinal peptide (VIP), the rela
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0019c4623eb5a4198104c2070f6995e9
https://pubmed.ncbi.nlm.nih.gov/8746541
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10
Differential expression of VIP/PACAP receptor genes in breast, intestinal, and pancreatic cell lines
Autor: James A. Waschek, Mark L. Richards, Dawn T. Bravo
Publikováno v: Cancer letters. 92(2)
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) are structurally-related neuropeptides that function as trophic factors in addition to their more classical roles as neurotransmitters. Binding and molecul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59391b0ffda7554025131b6c044ecbff
https://pubmed.ncbi.nlm.nih.gov/7600524
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