Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mark L. Peterson"'
Autor:
Loes M. Stevers, Madita Wolter, Graeme W. Carlile, Dwight Macdonald, Luc Richard, Frank Gielkens, John W. Hanrahan, David Y. Thomas, Sai Kumar Chakka, Mark L. Peterson, Helmut Thomas, Luc Brunsveld, Christian Ottmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Mutations in the chloride channel CFTR that impair plasma membrane insertion and ion transport are the cause of cystic fibrosis. Here, the authors identify a macrocycle that stabilizes the interaction of mutant CFTR with the chaperone-like protein 14
Externí odkaz:
https://doaj.org/article/92fd952667d14a1ba9705d63a6a37de1
Autor:
Kristine M. Kinniburgh, Mark L. Peterson, Hilary Hodgdon, Joseph Spinazzola, Margaret E. Blaustein
Publikováno v:
Journal of Child & Adolescent Trauma. 9:43-53
This project describes application of an evidenced-based, trauma-informed treatment framework, Attachment, Regulation and Competency (ARC), with adopted children impacted by complex trauma and their caregivers. Results demonstrate that ARC treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e73a4ea452611f03774701b7d42e9ae
https://doi.org/10.1007/s40653-015-0050-3
https://doi.org/10.1007/s40653-015-0050-3
Autor:
Eric Marsault, Mark L. Peterson
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to bui
Autor:
Mark L. Peterson
Publikováno v:
Macrocycles in Drug Discovery ISBN: 9781849737012
Despite the attractive nature of macrocyclic compounds for use in new pharmaceutical discovery, applications have been hindered due to the lack of appropriate synthetic methods, in particular for the construction of libraries of such molecules. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb4558c6c0f746d8a78b6715ea1c0b95
https://doi.org/10.1039/9781782623113-00398
https://doi.org/10.1039/9781782623113-00398
Publikováno v:
American Antiquity. 65:757-761
Glassow discusses several "problems" with the use of minimum number of individuals (MNI) in archaeological shellfish analysis, including the difficulty of identifying non-repetitive elements (NRE) to species level for several taxa. However, these pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5aa103eb084ca231cbb23c12b7b3e57
https://doi.org/10.2307/2694427
https://doi.org/10.2307/2694427
Publikováno v:
American Antiquity. 63:303-324
The California School of Midden Analysis represents a long-standing tradition of using weight, rather than minimum number of individuals (MNI), to analyze shell recovered from archaeological sites in California. This method originated at the Universi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f288f943e10fb8d78e2e3c1d36e3d280
https://doi.org/10.2307/2694700
https://doi.org/10.2307/2694700
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2853-2858
The simple 4-[(α-hydroxy)phosphonomethyl]-1H-pyrrole-2-carboxylate 4 is a surprisingly good S3P-analog inhibitor of EPSP synthase (competitive with S3P, Ki(app) = 14.5 ± 0.7 μM). The affinity of 4 for free enzyme is nearly comparable to that of S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce98630cabd1b2becda05fb591815eb7
https://doi.org/10.1016/s0960-894x(96)00527-6
https://doi.org/10.1016/s0960-894x(96)00527-6
Publikováno v:
ChemInform. 28
The simple 4-[(α-hydroxy)phosphonomethyl]-1H-pyrrole-2-carboxylate 4 is a surprisingly good S3P-analog inhibitor of EPSP synthase (competitive with S3P, Ki(app) = 14.5 ± 0.7 μM). The affinity of 4 for free enzyme is nearly comparable to that of S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19b4ae98b3cf4a62df479a6d40ac7b7d
https://doi.org/10.1002/chin.199716142
https://doi.org/10.1002/chin.199716142
Publikováno v:
ChemInform. 31
The preparation of several new EPSP synthase inhibitors is described where a pyrrole scaffold replaces the complex shikimate ring in S3P.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a092afcb9f4c3729bfb9834e1b5904e5
https://doi.org/10.1002/chin.200009274
https://doi.org/10.1002/chin.200009274
Publikováno v:
Catalysts to Complexity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfa7cc16da0231e0303acc7780bb3985
https://doi.org/10.2307/j.ctvhhhfdx.8
https://doi.org/10.2307/j.ctvhhhfdx.8