Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Mark L. Kahn"'
Autor:
Ying Li, Romuald Girard, Abhinav Srinath, Diana Vera Cruz, Cezary Ciszewski, Chang Chen, Rhonda Lightle, Sharbel Romanos, Je Yeong Sone, Thomas Moore, Dorothy DeBiasse, Agnieszka Stadnik, Justine J. Lee, Robert Shenkar, Janne Koskimäki, Miguel A. Lopez-Ramirez, Douglas A. Marchuk, Mark H. Ginsberg, Mark L. Kahn, Changbin Shi, Issam A. Awad
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that different cell types may play a role in CCM pathogenesis. The contribution of each cell type
Externí odkaz:
https://doaj.org/article/05cc7d1857bb4df3a29deb810717fcd3
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 116032- (2024)
Recent studies have described the importance of lymphatics in numerous organ-specific physiological and pathological processes. The role of meningeal lymphatics in various neurological and cerebrovascular diseases has been suggested. It has also been
Externí odkaz:
https://doaj.org/article/613722ba10d142f5b41fbfb4eafe7b25
Autor:
Abhinav Srinath, Bingqing Xie, Ying Li, Je Yeong Sone, Sharbel Romanos, Chang Chen, Anukriti Sharma, Sean Polster, Pieter C. Dorrestein, Kelly C. Weldon, Dorothy DeBiasse, Thomas Moore, Rhonda Lightle, Janne Koskimäki, Dongdong Zhang, Agnieszka Stadnik, Kristina Piedad, Matthew Hagan, Abdallah Shkoukani, Julián Carrión-Penagos, Dehua Bi, Le Shen, Robert Shenkar, Yuan Ji, Ashley Sidebottom, Eric Pamer, Jack A. Gilbert, Mark L. Kahn, Mark D’Souza, Dinanath Sulakhe, Issam A. Awad, Romuald Girard
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-15 (2023)
Srinath, Xie et al. analyze plasma metabolites present in patients with cerebral cavernous angiomas. Cholic acid and hypoxanthine are found in those with Cavernous Angioma disease whilst arachidonic and linoleic acids are found in Cavernous Angioma p
Externí odkaz:
https://doaj.org/article/f125c70ee54e447c80e887a9ef5a5e18
Autor:
Siqi Gao, Alan T. Tang, Min Wang, David W. Buchholz, Brian Imbiakha, Jisheng Yang, Xiaowen Chen, Peter Hewins, Patricia Mericko-Ishizuka, N. Adrian Leu, Stephanie Sterling, Avery August, Kellie A. Jurado, Edward E. Morrisey, Hector Aguilar-Carreno, Mark L. Kahn
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Endothelial damage and vascular pathology have been recognized as major features of COVID-19 since the beginning of the pandemic. Two main theories regarding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) damages endothelial cells a
Externí odkaz:
https://doaj.org/article/e5d15a44eed14d9d8481a9fdb43d3196
Autor:
Melanie Jannaway, Drishya Iyer, Diandra M. Mastrogiacomo, Kunyu Li, Derek C. Sung, Ying Yang, Mark L. Kahn, Joshua P. Scallan
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112777- (2023)
Summary: Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of large macromolecules, chylomicrons, and fluid from the interstitium. While excessive vascular endothelial growth factor 2 (VEGFR2) signaling can re
Externí odkaz:
https://doaj.org/article/d32a35d09e794a648c4f035b564b8b9f
Autor:
Barbara D. Summers, Kihwan Kim, Cristina C. Clement, Zohaib Khan, Sangeetha Thangaswamy, Jacob McCright, Katharina Maisel, Sofia Zamora, Stephanie Quintero, Alexandra C. Racanelli, David Redmond, Jeanine D’Armiento, Jisheng Yang, Amy Kuang, Laurel Monticelli, Mark L. Kahn, Augustine M. K. Choi, Laura Santambrogio, Hasina Outtz Reed
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The lymphatic vasculature is critical for lung function, but defects in lymphatic function in the pathogenesis of lung disease is understudied. In mice, lymphatic dysfunction alone is sufficient to cause lung injury that resembles human emph
Externí odkaz:
https://doaj.org/article/65625e4b867f4e81924ccad4d01752a0
Autor:
Phillip LR. Nicolson, John D. Welsh, Abhishek Chauhan, Mark R. Thomas, Mark L. Kahn, Steve P. Watson
Publikováno v:
Platelets, Vol 31, Iss 5, Pp 685-690 (2020)
Externí odkaz:
https://doaj.org/article/6f64a84c151d4dc79df556f229468625
Autor:
Sean P. Polster, Anukriti Sharma, Ceylan Tanes, Alan T. Tang, Patricia Mericko, Ying Cao, Julián Carrión-Penagos, Romuald Girard, Janne Koskimäki, Dongdong Zhang, Agnieszka Stadnik, Sharbel G. Romanos, Seán B. Lyne, Robert Shenkar, Kimberly Yan, Cornelia Lee, Amy Akers, Leslie Morrison, Myranda Robinson, Atif Zafar, Kyle Bittinger, Helen Kim, Jack A. Gilbert, Mark L. Kahn, Le Shen, Issam A. Awad
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Gut microbiome has been linked to cavernous angioma (CA), a common vascular disease, but the role in humans remains unclear. Here, the authors combine 16S rRNA sequencing and shotgun metagenomics to profile the microbiome in a large cohort of human s
Externí odkaz:
https://doaj.org/article/79327732fdd1439bb531e46396ad13b9
Autor:
Janne Koskimäki, Dongdong Zhang, Yan Li, Laleh Saadat, Thomas Moore, Rhonda Lightle, Sean P. Polster, Julián Carrión-Penagos, Seán B. Lyne, Hussein A. Zeineddine, Changbin Shi, Robert Shenkar, Sharbel Romanos, Kenneth Avner, Abhinav Srinath, Le Shen, Matthew R. Detter, Daniel Snellings, Ying Cao, Miguel A. Lopez-Ramirez, Gregory Fonseca, Alan T. Tang, Pieter Faber, Jorge Andrade, Mark Ginsberg, Mark L. Kahn, Douglas A. Marchuk, Romuald Girard, Issam A. Awad
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most aggressive familial form of the disease. Here we studied the diffe
Externí odkaz:
https://doaj.org/article/d491481086084d3caa544cf265ff3ba4
Autor:
Kitti Szoták-Ajtay, Dániel Szõke, Gábor Kovács, Judit Andréka, Gábor B. Brenner, Zoltán Giricz, Josef Penninger, Mark L. Kahn, Zoltán Jakus
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Embryonic lungs must be inflated immediately after birth to establish respiration. In addition to pulmonary surfactant, recently, we have revealed lymphatic function as a previously unknown regulator of prenatal lung compliance that prepares the embr
Externí odkaz:
https://doaj.org/article/7383518730544accb2f7c18fed886b0d