Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Mark L. Hanke"'
Autor:
Julia Kargl, Stephanie E. Busch, Grace H. Y. Yang, Kyoung-Hee Kim, Mark L. Hanke, Heather E. Metz, Jesse J. Hubbard, Sylvia M. Lee, David K. Madtes, Martin W. McIntosh, A. McGarry Houghton
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Tumour immune evasion can involve multiple strategies. Here, the authors characterize the immune populations from clinical specimens of lung cancer in conjunction with TCR-β sequencing and show abundant neutrophils affecting cytotoxic T-cell content
Externí odkaz:
https://doaj.org/article/e3ccc629fbf04585997cc516e4b37d35
Autor:
Tyler D. Scherr, Mark L. Hanke, Ouwen Huang, David B. A. James, Alexander R. Horswill, Kenneth W. Bayles, Paul D. Fey, Victor J. Torres, Tammy Kielian
Publikováno v:
mBio, Vol 6, Iss 4 (2015)
ABSTRACT The macrophage response to planktonic Staphylococcus aureus involves the induction of proinflammatory microbicidal activity. However, S. aureus biofilms can interfere with these responses in part by polarizing macrophages toward an anti-infl
Externí odkaz:
https://doaj.org/article/c55082d268f9458ca6c96b049b4388eb
Publikováno v:
Open Access Rheumatology : Research and Reviews
Nancy Ho-Mahler,1 Beni Turner,2 Michael Eaddy,2 Mark L Hanke,1 Winnie W Nelson1 1Mallinckrodt Pharmaceuticals, Bedminster, NJ, USA; 2Xcenda, Palm Harbor, FL, USACorrespondence: Nancy Ho-MahlerMallinckrodt Pharmaceuticals, 1425 U.S. Route 206, Bedmins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400454f6e75a3897d5a3e710d5cc61d4
https://www.dovepress.com/treatment-with-repository-corticotropin-injection-in-patients-with-rhe-peer-reviewed-article-OARRR
https://www.dovepress.com/treatment-with-repository-corticotropin-injection-in-patients-with-rhe-peer-reviewed-article-OARRR
Autor:
Mark L Hanke, Tammy eKielian
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
Biofilms are adherent communities of bacteria contained within a complex matrix. Although host immune responses to planktonic staphylococcal species have been relatively well-characterized, less is known regarding immunity to staphylococcal biofilms
Externí odkaz:
https://doaj.org/article/bcfe3bf2f47b446dab89d1246a1751fc
Autor:
Austin S Nuxoll, Steven M Halouska, Marat R Sadykov, Mark L Hanke, Kenneth W Bayles, Tammy Kielian, Robert Powers, Paul D Fey
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003033 (2012)
Staphylococcus aureus is a leading cause of community-associated and nosocomial infections. Imperative to the success of S. aureus is the ability to adapt and utilize nutrients that are readily available. Genomic sequencing suggests that S. aureus ha
Externí odkaz:
https://doaj.org/article/e7fbea896fec408a8fdbd01faeadcb36
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42476 (2012)
Bacterial biofilms represent a significant therapeutic challenge based on their ability to evade host immune and antibiotic-mediated clearance. Recent studies have implicated IL-1β in biofilm containment, whereas Toll-like receptors (TLRs) had no ef
Externí odkaz:
https://doaj.org/article/d1c9283770764e10b6322a2cf6fd2e7a
Autor:
Jesse J. Hubbard, Martin W. McIntosh, Heather E. Metz, Grace H. Y. Yang, A. McGarry Houghton, Mark L. Hanke, Kyoung-Hee Kim, Sylvia Lee, David K. Madtes, Julia Kargl, Stephanie E. Busch
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The response rate to immune checkpoint inhibitor therapy for non-small-cell lung cancer (NSCLC) is just 20%. To improve this figure, several early phase clinical trials combining novel immunotherapeutics with immune checkpoint blockade have been init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676090384ac964abd16304f02b762f6c
https://doaj.org/article/e3ccc629fbf04585997cc516e4b37d35
https://doaj.org/article/e3ccc629fbf04585997cc516e4b37d35
Autor:
Mark L. Hanke, Heather E. Metz, Julia Kargl, David MacPherson, A. McGarry Houghton, Stephanie E. Busch
Publikováno v:
The Journal of Immunology. 197:4493-4503
Lung cancer, the leading cause of cancer-related deaths worldwide, is a heterogeneous disease comprising multiple histologic subtypes that harbor disparate mutational profiles. Immune-based therapies have shown initial promise in the treatment of lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18cdf8f52c22eacc52236fc5811bf99
https://doi.org/10.4049/jimmunol.1600576
https://doi.org/10.4049/jimmunol.1600576
Autor:
Tamara Lushnikova, Tammy Kielian, Kenneth W. Bayles, Mark L. Hanke, Vinai Chittezham Thomas, Cortney E. Heim, Biswajit Mishra, Guangshun Wang
Publikováno v:
ACS Chemical Biology
This Letter reports a family of novel antimicrobial compounds obtained by combining peptide library screening with structure-based design. Library screening led to the identification of a human LL-37 peptide resistant to chymotrypsin. This d-amino-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afcf854ad865fc120fb78f28034d20e
https://doi.org/10.1021/cb500475y
https://doi.org/10.1021/cb500475y
Autor:
Eric C. Holland, Mark L. Hanke, Daciana Margineantu, Jeff Delrow, Julia Kargl, A. McGarry Houghton, Nduka Amankulor, Sonali Arora, Aparna Rao, Frank Szulzewsky, David M. Hockenbery, Hamid Bolouri, Youngmi Kim
Publikováno v:
Genesdevelopment. 31(8)
Gliomas harboring mutations in isocitrate dehydrogenase 1/2 (IDH1/2) have the CpG island methylator phenotype (CIMP) and significantly longer patient survival time than wild-type IDH1/2 (wtIDH1/2) tumors. Although there are many factors underlying th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788c359af829a9a789bbe68f60ef90f0
https://pubmed.ncbi.nlm.nih.gov/28465358
https://pubmed.ncbi.nlm.nih.gov/28465358