Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mark L. Benson"'
Inherent versus induced protein flexibility: Comparisons within and between apo and holo structures.
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006705 (2019)
Understanding how ligand binding influences protein flexibility is important, especially in rational drug design. Protein flexibility upon ligand binding is analyzed herein using 305 proteins with 2369 crystal structures with ligands (holo) and 1679
Externí odkaz:
https://doaj.org/article/e8871005ed6d453886e9c22a793447a0
Autor:
John C Faver, Mark L Benson, Xiao He, Benjamin P Roberts, Bing Wang, Michael S Marshall, C David Sherrill, Kenneth M Merz
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18868 (2011)
The routine prediction of three-dimensional protein structure from sequence remains a challenge in computational biochemistry. It has been intuited that calculated energies from physics-based scoring functions are able to distinguish native from nonn
Externí odkaz:
https://doaj.org/article/2e6c4b67094a468397447350c0fdd380
Autor:
Jennifer M. Lee, George R. Riley, Chen Chao, Kurt McDaniel, Brandi L. Kattman, Donna Maglott, Zenith Maddipatla, Melissa J. Landrum, Baoshan Gu, Douglas W. Hoffman, Kenneth S. Katz, Garth Brown, J. Bradley Holmes, Mark L. Benson, George Zhou, Karen Karapetyan, Chunlei Liu, Shanmuga Chitipiralla, Michael Ovetsky, Malheiro Aj, Wonhee Jang, Jennifer Hart
Publikováno v:
Nucleic Acids Research
ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/) is a freely available, public archive of human genetic variants and interpretations of their significance to disease, maintained at the National Institutes of Health. Interpretations of the clinical sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093ae270a1616614cdabe12da24c0614
http://europepmc.org/articles/PMC5753237
http://europepmc.org/articles/PMC5753237
Publikováno v:
SUMO Regulation of Cellular Processes ISBN: 9783319500430
Recently, a role for SUMO modification outside of the nucleus has emerged. Although the number of extranuclear proteins known to be sumoylated is comparatively small, ion channels represent one important new class of these proteins. Ion channels are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d651894bbbabb804cce85e1d25ad21f3
https://doi.org/10.1007/978-3-319-50044-7_8
https://doi.org/10.1007/978-3-319-50044-7_8
Autor:
John C. Faver, Melek N. Ucisik, Kenneth M. Merz, Zheng Zheng, Danial Sabri Dashti, Mark L. Benson
Publikováno v:
Journal of Computer-Aided Molecular Design. 26:647-659
Two families of binding affinity estimation methodologies are described which were utilized in the SAMPL3 trypsin/fragment binding affinity challenge. The first is a free energy decomposition scheme based on a thermodynamic cycle, which included sepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ab537a60c912e12c5cdb4ad0c8a249
https://doi.org/10.1007/s10822-012-9567-9
https://doi.org/10.1007/s10822-012-9567-9
Autor:
Matthew R. Kennedy, Michael S. Marshall, Benjamin P. Roberts, Xiao He, C. David Sherrill, Mark L. Benson, Bing Wang, Kenneth M. Merz, John C. Faver
Publikováno v:
Journal of Chemical Theory and Computation. 7:790-797
A largely unsolved problem in computational biochemistry is the accurate prediction of binding affinities of small ligands to protein receptors. We present a detailed analysis of the systematic and random errors present in computational methods throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f004f8b7bfa21435faada3c81929e3
https://doi.org/10.1021/ct100563b
https://doi.org/10.1021/ct100563b
Autor:
Heather A. Carlson, Mark L. Benson, Richard D. Smith, Nickolay A. Khazanov, Brandon Dimcheff, Peter Dresslar
Publikováno v:
New Mathematics and Natural Computation. (01):49-56
Binding MOAD (Mother of All Databases) is the largest collection of high-quality, protein-ligand complexes available from the Protein Data Bank. It has grown to 9837 hand-curated entries. Here, we describe our semi-annual updating procedures and BUDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1cc8573b7f0a2cde7129956c5d697e
http://www.worldscinet.com/cgi-bin/details.cgi?type=pdf&id=pii:S1793005710001608
http://www.worldscinet.com/cgi-bin/details.cgi?type=pdf&id=pii:S1793005710001608
Autor:
Wayne M. Butler, Jonathan H. Lief, Mark L Benson, Robert W. Galbreath, Kent E. Wallner, Gregory S. Merrick
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 50:597-604
Purpose: To retrospectively evaluate the relationship between the radiation dose to the bulb of the penis and the development of erectile dysfunction (ED) in patients undergoing permanent prostate brachytherapy without external beam radiation therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab37517004719b1d9126852db55afc47
https://doi.org/10.1016/s0360-3016(01)01475-4
https://doi.org/10.1016/s0360-3016(01)01475-4
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 46:215-220
Purpose: Although postoperative dosimetric analyses of prostate brachytherapy are commonly reported, the long-term persistence, or fixity, of seeds implanted in the prostate gland and periprostatic region remains unclear, with only a few reports rega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5325efed843621b305b43d92e182ed
https://doi.org/10.1016/s0360-3016(99)00405-8
https://doi.org/10.1016/s0360-3016(99)00405-8
Publikováno v:
Otolaryngologic Clinics of North America. 28:585-608
This article details the imaging modalities available for patients being considered for functional endoscopic sinus surgery. The pertinent radiologic anatomy is reviewed with an emphasis on normal variations. Imaging appearances of inflammatory sinus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c65ddaf6083eb7f6186f65672aadcdfb
https://doi.org/10.1016/s0030-6665(20)30520-x
https://doi.org/10.1016/s0030-6665(20)30520-x