Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mark L. Behnke"'
Autor:
Michael Foley, Andre Lescarbeau, Martin R. Tremblay, Lombardy Richard John, Grogan Michael John, Andrew B. Hague, Kristopher M. Depew, Jimin Xiong, Joseph Helble, Priscilla L. White, Julian Adams, Brian C. Austad, Caroline D. Lory, Somarajan J. Nair, Stéphane Peluso, Lin-Chen Yu, Alfredo C. Castro, André B. Charette, Benjamin S. Lane, Jeanne Shaffer, Louis Grenier, James R. Porter, Matthew Campbell, Koney Nii O, Mark L. Behnke
Publikováno v:
Organic Process Research & Development. 20:786-798
The formation of the d-homocyclopamine ring system in IPI-926 is the key step in its semisynthesis and proceeds via a chemoselective cyclopropanation followed by a stereoselective acid-catalyzed carbocation rearrangement. In order to perform large-sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9debb0b604cbda59d104def86c7642
https://doi.org/10.1021/acs.oprd.6b00048
https://doi.org/10.1021/acs.oprd.6b00048
Autor:
Yuhua Zhang, Mark L. Behnke, Frank Lovering, Jeremy I. Levin, Arie Zask, Vincent Sandanayaka, Yi Zhu, Zhang Chunchun, Weixin Xu, LinHong Sun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3445-3448
A series of alpha-sulfone piperidine hydroxamate TACE inhibitors 11a-n bearing a quinolinyl methyl P1' group was prepared, and their activity was compared to analogous alpha- and beta-sulfone piperidine hydroxamates with a butynyloxy P1' group. The q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acad3717e578e23a1173302253b27a1
https://doi.org/10.1016/j.bmcl.2009.05.020
https://doi.org/10.1016/j.bmcl.2009.05.020
Autor:
Matthew Campbell, Caroline N. Woodward, Jens Sydor, Alfredo C. Castro, James R. Porter, Margaret A. Read, Kerrie Faia, Kerry White, Martin R. Tremblay, Jill Cushing, Julian Adams, Lin-Chen Yu, Mark L. Behnke, Jennifer Hoyt, Vito J. Palombella, Karen McGovern, Somarajan J. Nair, Jeffrey K. Tong, Margit Hagel, Marta Nevalainen, Louis Grenier, Michael Foley
Publikováno v:
Journal of Medicinal Chemistry. 51:6646-6649
Herein is reported the synthesis of a novel class of hedgehog antagonists derived from cyclopamine. The acid sensitive D-ring of cyclopamine was homologated utilizing a sequence of chemoselective cyclopropanation and stereoselective acid-catalyzed re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d0752adc424ed0f2bb4f871b70a4f4
https://doi.org/10.1021/jm8008508
https://doi.org/10.1021/jm8008508
Autor:
Megan A. Foley, M. Sherry Ku, Cheryl Nickerson-Nutter, Lihren Chen, Weiheng Wang, Manjunath K. Ramarao, Marina W.H. Shen, Debra G. Goodwin, Katherine L. Lee, Tam Steve Yik-Kai, Jaechul Shim, Mark L. Behnke, SooPeang Khor, John C. McKew, Xin Xu, Steven J. Kirincich, Frank Lovering, Frances Donahue, James D. Clark
Publikováno v:
Journal of Medicinal Chemistry. 50:1380-1400
The synthesis and structure-activity relationship of a series of indole inhibitors of cytosolic phospholipase A2alpha (cPLA2alpha, type IVA phospholipase) are described. Inhibitors of cPLA2alpha are predicted to be efficacious in treating asthma as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f309b58c1ad34e2e7e4cbf67afce20
https://doi.org/10.1021/jm061131z
https://doi.org/10.1021/jm061131z
Autor:
Julian Adams, Teresa A. McCormack, Francois Soucy, Louis Grenier, Mark L. Behnke, Louis Plamondon, Antonia T. Destree
Publikováno v:
Journal of the American Chemical Society. 121:9967-9976
Herein, we describe a new convergent synthesis of a more potent analogue of clasto-lactacystin β-lactone (2), PS-519 compound 4, which is currently in preclinical development for the treatment of i...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3784821bda3206f5a6c70e267b40fe2c
https://doi.org/10.1021/ja991175f
https://doi.org/10.1021/ja991175f
Autor:
Louis Plamondon, Shaowu Chen, Janice M. Klunder, Amy A. Cruickshank, Julian Adams, Yu-Ting Ma, Lawrence R. Dick, Mark L. Behnke, Louis Grenier, Ross L. Stein
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:333-338
Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such as 15 are promising new therapeutics for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba35bcdbd26e8db5d1f183ac78cb8945
https://doi.org/10.1016/s0960-894x(98)00029-8
https://doi.org/10.1016/s0960-894x(98)00029-8
Publikováno v:
Tetrahedron Letters. 34:6205-6208
A general synthetic method is reported for the preparation of cis-2,3-disubstituted pyrrolidines and piperidines from readily available acyclic precursors. The key reaction involves the stereoselective reduction of a cyclic imine controlled by the C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb0e4b2c0eec3c99cfb8e0e9e1b5ac70
https://doi.org/10.1016/s0040-4039(00)73710-5
https://doi.org/10.1016/s0040-4039(00)73710-5
Autor:
Suresh R. Kapadia, Janice M. Klunder, W. W. Engel, John R. Proudfoot, Guenther Schmidt, S. C. Mauldin, Usha R. Patel, Janice M. Rose, Alan S. Rosenthal, Kollol Pal, K. D. Hargrave, T. D. Saboe, Scot J. Campbell, Jerry W. Skiles, Mark L. Behnke, Mark T. Skoog, Joe C. Wu, W. G. Eberlein, Jana Vitous, Julian Adams, Grace C. Chow, Ernest Cullen, Grozinger Karl G, Victor Fuchs, Mcneil Daniel W
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5c008debc58da9d4d5584d876714947
https://doi.org/10.1002/chin.199152234
https://doi.org/10.1002/chin.199152234
Autor:
Sorcek Ronald J, Julian Adams, Lazer Edward S, J. M. Watrous, Yvan Guindon, H.‐C. Wong, Carol Ann Homon, Kollol Pal, Jürgen H. Nagel, Mark L. Behnke, A. Shah, Miao Clara K, A. G. Graham, A. Gilman, Denice M. Spero, Peter R. Farina
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ade8f0d4a443d8ee74fe9e365953d8c0
https://doi.org/10.1002/chin.199434152
https://doi.org/10.1002/chin.199434152
Publikováno v:
ChemInform. 25
A general synthetic method is reported for the preparation of cis-2,3-disubstituted pyrrolidines and piperidines from readily available acyclic precursors. The key reaction involves the stereoselective reduction of a cyclic imine controlled by the C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b2b368c8c9ab86713f41ebe2429b5d2
https://doi.org/10.1002/chin.199412111
https://doi.org/10.1002/chin.199412111