Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Mark L Smythe"'
Autor:
Md Ashik Ullah, Sonja Rittchen, Jia Li, Bodie F. Curren, Patricia Namubiru, Tufael Ahmed, Daniel R. Howard, Muhammed Mahfuzur Rahman, Md Al Amin Sikder, Ridwan B. Rashid, Natasha Collinson, Mary Lor, Mark L. Smythe, Simon Phipps
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Prostaglandin D2 (PGD2) signals via the DP1 and DP2 receptors. In Phase II trials, DP2 antagonism decreased airway inflammation and airway smooth muscle (ASM) area in moderate-to-severe asthma patients. However, in Phase III, DP2 antagonism
Externí odkaz:
https://doaj.org/article/79fc51faccbe49b78c3e7f49b0106c6b
Autor:
Sheila Ranganath, Ashok Bhandari, Nicole Avitahl-Curtis, Jaimee McMahon, Derek Wachtel, Jenny Zhang, Christopher Leitheiser, Sylvie G Bernier, Guang Liu, Tran T Tran, Herodion Celino, Jenny Tobin, Joon Jung, Hong Zhao, Katie E Glen, Chris Graul, Aliesha Griffin, Wayne C Schairer, Carolyn Higgins, Tammi L Reza, Eva Mowe, Sam Rivers, Sonya Scott, Alex Monreal, Courtney Shea, Greg Bourne, Casey Coons, Adaline Smith, Kim Tang, Ramya A Mandyam, Jaime Masferrer, David Liu, Dinesh V Patel, Angelika Fretzen, Craig A Murphy, G Todd Milne, Mark L Smythe, Kenneth E Carlson
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141330 (2015)
Interleukin-6 (IL-6) is an important member of the cytokine superfamily, exerting pleiotropic actions on many physiological processes. Over-production of IL-6 is a hallmark of immune-mediated inflammatory diseases such as Castleman's Disease (CD) and
Externí odkaz:
https://doaj.org/article/79b1eaa807e1438c8eaa8708c553dbc5
Publikováno v:
Life, Vol 11, Iss 9, p 994 (2021)
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness and wasting due to the lack of dystrophin protein. The acute phase of DMD is characterized by muscle necrosis and increased levels of the pro-inflammatory mediator, pro
Externí odkaz:
https://doaj.org/article/82b1201c93ed43c59e5418cae1a4879a
Autor:
Li Zhao, David Liu, Jayanthi Vengalam, Larry C. Mattheakis, Brian Troy Frederick, Larry Lee, Lucy Yuan, Ashok Bhandari, Jie Zhang, Celino Dion, Gregory T. Bourne, Mohammad Masjedizadeh, James Tovera, Jaimee McMahon, Tran Trung Tran, Bo Yang, Grace A Ledet, Mark L. Smythe, Keith Huie, Genet Zemede, Michelle Nadeau Nguyen, Xiaoli Cheng, Roopa Taranath
Publikováno v:
Blood. 136:47-48
Hepcidin peptidomimetics that are orally stable and systemically active will mark a paradigm change in management of blood disorders that exhibit aberrant iron homeostasis (e.g. hereditary hemochromatosis) and in conditions that can be influenced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e518ac834d36c422f399daf95320d6
https://doi.org/10.1182/blood-2020-141720
https://doi.org/10.1182/blood-2020-141720
Autor:
Jason P. Lynch, Jennifer Simpson, John W. Upham, Mark L. Smythe, Kirsten Spann, Vivian Zhang, Matthew Wee-Peng Poh, Christina Kulis, Nick H. Hodge, Simon Phipps, Elizabeth Forbes-Blom, Rhiannon B. Werder, Mark L. Everard
Publikováno v:
Science Translational Medicine. 10
Prostaglandin D2 (PGD2) signals through PGD2 receptor 2 (DP2, also known as CRTH2) on type 2 effector cells to promote asthma pathogenesis; however, little is known about its role during respiratory syncytial virus (RSV) bronchiolitis, a major risk f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a70fab671affc168301e6ee0166cd1e2
https://doi.org/10.1126/scitranslmed.aao0052
https://doi.org/10.1126/scitranslmed.aao0052
Autor:
Rhiannon B, Werder, Jason P, Lynch, Jennifer C, Simpson, Vivian, Zhang, Nick H, Hodge, Matthew, Poh, Elizabeth, Forbes-Blom, Christina, Kulis, Mark L, Smythe, John W, Upham, Kirsten, Spann, Mark L, Everard, Simon, Phipps
Publikováno v:
Science translational medicine. 10(440)
Prostaglandin D2 (PGD2) signals through PGD2 receptor 2 (DP2, also known as CRTH2) on type 2 effector cells to promote asthma pathogenesis; however, little is known about its role during respiratory syncytial virus (RSV) bronchiolitis, a major risk f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d6c102ee6eb21b6961f0faf3ee251c10
https://pubmed.ncbi.nlm.nih.gov/29743346
https://pubmed.ncbi.nlm.nih.gov/29743346
Autor:
Mark L. Smythe, Tran Trung Tran, Andrej Sali, Herodion Celino, Ashok Bhandari, Charles S. Craik, David T. Barkan, Xiaoli Cheng
Publikováno v:
BMC Bioinformatics
Background Disulfide-rich peptides (DRPs) are found throughout nature. They are suitable scaffolds for drug development due to their small cores, whose disulfide bonds impart extraordinary chemical and biological stability. A challenge in developing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6389a5c98db55cacb73b7123d50c08ce
https://pubmed.ncbi.nlm.nih.gov/27881076
https://pubmed.ncbi.nlm.nih.gov/27881076
Autor:
Jack U. Flanagan, Mark L. Smythe
Publikováno v:
Drug Metabolism Reviews. 43:194-214
Mammalian cytosolic glutathione transferases (GSTs) can be grouped into seven classes. Of these, the sigma class is also widely distributed in nature, with isoforms found in both vertebrates and invertebrates. It contains examples of proteins that ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300d4929b9f36825056d32e18d81f9ba
https://doi.org/10.3109/03602532.2011.560157
https://doi.org/10.3109/03602532.2011.560157
Publikováno v:
Journal of Computational Chemistry. 32:1541-1549
A new population-based incremental learning algorithm for conformational searching of molecules is presented. This algorithm is particularly effective at determining, by relatively small number of energy minimizations, global energy minima of large f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffdfab008b301719f413d6eec222f40
https://doi.org/10.1002/jcc.21732
https://doi.org/10.1002/jcc.21732
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 9:559-563
Combinatorial chemistry has become an invaluable tool in medicinal chemistry for the identification of new drug leads. For example, libraries of predetermined sequences and head-to-tail cyclized peptides are routinely synthesized in our laboratory us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798b3ef1a0311c565ca2ad25144f465d
https://doi.org/10.2174/138620706777935333
https://doi.org/10.2174/138620706777935333