Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Mark L Mayer"'
Autor:
Mark L Mayer, Timothy Jegla
Publikováno v:
eLife, Vol 7 (2018)
Genome sequence data from a range of animal species are raising questions about the origins of glutamate receptors.
Externí odkaz:
https://doaj.org/article/4fb222e8a9e749ee8b07c422ba6592ce
Publikováno v:
eLife, Vol 6 (2017)
Ion conductivity and the gating characteristics of tetrameric glutamate receptor ion channels are determined by their subunit composition. Competitive homo- and hetero-dimerization of their amino-terminal domains (ATDs) is a key step controlling asse
Externí odkaz:
https://doaj.org/article/78527d336bf84b1d96eea10e51153c51
Autor:
Huaying Zhao, Yan Fu, Carla Glasser, Eric J Andrade Alba, Mark L Mayer, George Patterson, Peter Schuck
Publikováno v:
eLife, Vol 5 (2016)
The dynamic assembly of multi-protein complexes underlies fundamental processes in cell biology. A mechanistic understanding of assemblies requires accurate measurement of their stoichiometry, affinity and cooperativity, and frequently consideration
Externí odkaz:
https://doaj.org/article/07db3e12ea6b4d9d81a7cec3f59ba488
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83439 (2013)
Sedimentation velocity analytical ultracentrifugation (SV) is a powerful first-principle technique for the study of protein interactions, and allows a rigorous characterization of binding stoichiometry and affinities. A recently introduced commercial
Externí odkaz:
https://doaj.org/article/8d8b5c9d28d84b0fbfb21f9efbd19110
Autor:
Mark L. Mayer
Publikováno v:
Trends in Pharmacological Sciences. 42:507-509
Single-channel analysis previously revealed a key role for a short-lived 'flipped' state during glycine receptor activation by partial agonists. Structures solved by Yu and colleagues now reveal a surprising mechanism involving a partially activated
Autor:
Mark L. Mayer
Publikováno v:
The Journal of Physiology. 599:2605-2613
The identification of AMPA, kainate and NMDA glutamate receptor subtypes by Watkins and colleagues underlies much of our understanding of excitatory synaptic transmission in the central nervous system of animals. Ongoing large scale genome sequencing
Autor:
R.H. Evans, David Ramos-Vicente, Ada Rodríguez-Campuzano, Jack R. Mellor, Yu Tian Wang, Sam A. Booker, David J. A. Wyllie, Antonio Rodríguez-Moreno, Elek Molnár, Lonnie P. Wollmuth, Jeffrey C. Watkins, Arturo Ortega, Min Zhuo, Li Niu, Àlex Bayés, Mark L. Mayer, Bruno G. Frenguelli, Alasdair J. Gibb, Yuriy Pankratov, Lu-Yang Wang, Angela M. Mabb
Publikováno v:
NEUROPHARMACOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
In 1981 Jeff Watkins and Dick Evans wrote what was to become a seminal review on excitatory amino acids (EAAs) and their receptors (Watkins and Evans, 1981). Bringing together various lines of evidence dating back over several decades on: the distrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e20081a690b6bee5806285ecd11d02
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4257
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4257
Autor:
Mark L. Mayer
Publikováno v:
Neuropharmacology. 190
This review summarizes structural studies on kainate receptors that explain unique functional properties of this receptor family. A large number of structures have been solved for ligand binding domain dimer assemblies, giving insight into the subtyp
Autor:
Ingo H. Greger, Mark L Mayer
Publikováno v:
Current opinion in structural biology. 57
Ionotropic glutamate receptors (iGluRs) are tetrameric ion channels that mediate signal transmission at neuronal synapses, where they contribute centrally to the postsynaptic plasticity that underlies learning and memory. Receptor activation by l -gl
Autor:
Sagar Chittori, Mark L. Mayer, Joel R. Meyerson, Mihaela Serpe, Alan Merk, Sriram Subramaniam, Prashant Rao, Tae Hee Han
Publikováno v:
Nature
The high-resolution cryo-electron microscopy structure of the kainate receptor GluK2 subtype in its desensitized state is reported, which reveals that desensitization is attained by establishing a ring-like structure in the ligand-binding domains. AM