Zobrazeno 1 - 10 of 353 pro vyhledávání: '"Mark L Evans"'
1
Elektronická kniha
USS Enterprise (CVN-65) : The First Nuclear Powered Aircraft Carrier
Autor: Mark L. Evans
This is the thrilling story of USS Enterprise (CVN-65), the world's first nuclear-powered aircraft carrier. Her story spans 51 years (1961-2012) of active service from the brink of nuclear war during the Cuban Missile Crisis to the first global cruis
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2
Akademický článek
Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes
Autor: Jia-Yuan Zhang, Fiona Hamey, Dominik Trzupek, Marius Mickunas, Mercede Lee, Leila Godfrey, Jennie H. M. Yang, Marcin L. Pekalski, Jane Kennet, Frank Waldron-Lynch, Mark L. Evans, Timothy I. M. Tree, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Low-dose interleukin-2 is showing promise in the treatment of several autoimmune inflammatory diseases. Here authors map the trajectory of cellular and transcriptional changes in type 1 diabetes patients receiving an interval dosing interleukin-2 reg
Externí odkaz: https://doaj.org/article/1cbfc186befb4c289f8694e2f8ebe72c
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3
Akademický článek
Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes
Autor: Ali J. Chakera, Paul S. Hurst, Gill Spyer, Emmanuel O. Ogunnowo-Bada, William J. Marsh, Christine H. Riches, Chen-Yu Yueh, S. Pauliina Markkula, Jeffrey W. Dalley, Roger D. Cox, Ian A. Macdonald, Stephanie A. Amiel, Kenneth M. MacLeod, Lora K. Heisler, Andrew T. Hattersley, Mark L. Evans
Publikováno v: Molecular Metabolism, Vol 17, Iss , Pp 17-27 (2018)
Objective: Appropriate glucose levels are essential for survival; thus, the detection and correction of low blood glucose is of paramount importance. Hypoglycemia prompts an integrated response involving reduction in insulin release and secretion of
Externí odkaz: https://doaj.org/article/5aa2ee6354054a39a0a0b99baae7f83c
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4
Akademický článek
Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights
Autor: Nicholas Heeley, Peter Kirwan, Tamana Darwish, Marion Arnaud, Mark L. Evans, Florian T. Merkle, Frank Reimann, Fiona M. Gribble, Clemence Blouet
Publikováno v: Molecular Metabolism, Vol 10, Iss , Pp 14-27 (2018)
Objective: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which hypothalamic neural cir
Externí odkaz: https://doaj.org/article/ca276ba2670243aeb41eb1b77aef2f9a
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6
Akademický článek
Lorcaserin improves glycemic control via a melanocortin neurocircuit
Autor: Luke K. Burke, Emmanuel Ogunnowo-Bada, Teodora Georgescu, Claudia Cristiano, Pablo B. Martinez de Morentin, Lourdes Valencia Torres, Giuseppe D'Agostino, Christine Riches, Nicholas Heeley, Yue Ruan, Marcelo Rubinstein, Malcolm J. Low, Martin G. Myers, Justin J. Rochford, Mark L. Evans, Lora K. Heisler
Publikováno v: Molecular Metabolism, Vol 6, Iss 10, Pp 1092-1102 (2017)
Objective: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the identification of new medicat
Externí odkaz: https://doaj.org/article/d5d57fc4ef3a41a08e876808e1d9eeec
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8
Akademický článek
Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons
Autor: Luke K. Burke, Barbora Doslikova, Giuseppe D'Agostino, Megan Greenwald-Yarnell, Teodora Georgescu, Raffaella Chianese, Pablo B. Martinez de Morentin, Emmanuel Ogunnowo-Bada, Celine Cansell, Lourdes Valencia-Torres, Alastair S. Garfield, John Apergis-Schoute, Daniel D. Lam, John R. Speakman, Marcelo Rubinstein, Malcolm J. Low, Justin J. Rochford, Martin G. Myers, Mark L. Evans, Lora K. Heisler
Publikováno v: Molecular Metabolism, Vol 5, Iss 3, Pp 245-252 (2016)
Objective: Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight. Central among these integration nodes are the brain pro-
Externí odkaz: https://doaj.org/article/c6e907e380bc4741a86d183bf11641af
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9
Fully automated closed-loop insulin delivery in adults with type 2 diabetes: an open-label, single-center, randomized crossover trial
Autor: Aideen B. Daly, Charlotte K. Boughton, Munachiso Nwokolo, Sara Hartnell, Malgorzata E. Wilinska, Alina Cezar, Mark L. Evans, Roman Hovorka
Funder: Dexcom supplied discounted continuous glucose monitoring devices and sensors for the study; company representatives had no role in the study conduct. Supported by National Institute for Health and Care Research Cambridge Biomedical Research C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cbef99f56ca38c8bf3486aca7ca6af
https://www.repository.cam.ac.uk/handle/1810/345406
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