Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Mark L, Dell'Acqua"'
Autor:
Sarah C. Simmons, William J. Flerlage, Ludovic D. Langlois, Ryan D. Shepard, Christopher Bouslog, Emily H. Thomas, Kaitlyn M. Gouty, Jennifer L. Sanderson, Shawn Gouty, Brian M. Cox, Mark L. Dell’Acqua, Fereshteh S. Nugent
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability. Emerging evidence also suggests that AKAP150 signaling may p
Externí odkaz:
https://doaj.org/article/d0756070792248e3952cc58c533d07ad
Autor:
Kevin P. Koster, Zach Fyke, Thu T. A. Nguyen, Amanda Niqula, Lorena Y. Noriega-González, Kevin M. Woolfrey, Mark L. Dell’Acqua, Stephanie M. Cologna, Akira Yoshii
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 16 (2024)
Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation. The depalmitoylating enzyme, palmitoyl-protein thioesterase 1 (PPT1), is associat
Externí odkaz:
https://doaj.org/article/e3a613aeb95d49d588cfd343ac8d71e8
Autor:
Esteban M. Lucero, Ronald K. Freund, Alexandra Smith, Noah R. Johnson, Breanna Dooling, Emily Sullivan, Olga Prikhodko, Md. Mahiuddin Ahmed, David A. Bennett, Timothy J. Hohman, Mark L. Dell’Acqua, Heidi J. Chial, Huntington Potter
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105288- (2022)
Summary: Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter and neurotrophin receptor localization and function. T
Externí odkaz:
https://doaj.org/article/b454f82fd1d14209a2333f435a60d98d
Autor:
Xiaobing Chen, Kevin C. Crosby, Austin Feng, Alicia M. Purkey, Maria A. Aronova, Christine A. Winters, Virginia T. Crocker, Richard D. Leapman, Thomas S. Reese, Mark L. Dell’Acqua
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
A-kinase anchoring protein 79-human/150-rodent (AKAP79/150) organizes signaling proteins to control synaptic plasticity. AKAP79/150 associates with the plasma membrane and endosomes through its N-terminal domain that contains three polybasic regions
Externí odkaz:
https://doaj.org/article/4c26f9a0611f46cbba8fda88c1d0d6a0
Autor:
Sara E. Gookin, Matthew R. Taylor, Samantha L. Schwartz, Matthew J. Kennedy, Mark L. Dell’Acqua, Kevin C. Crosby, Katharine R. Smith
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
The nanoscale architecture of synapses has been investigated using multiple super-resolution methods, revealing a common modular structure for scaffolds, neurotransmitter receptors, and presynaptic proteins. This fundamental organization of proteins
Externí odkaz:
https://doaj.org/article/ce3db4c3150a42509ceaf51515256aad
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109786- (2021)
Summary: Regulated insertion and removal of postsynaptic AMPA glutamate receptors (AMPARs) mediates hippocampal long-term potentiation (LTP) and long-term depression (LTD) synaptic plasticity underlying learning and memory. In Alzheimer’s disease
Externí odkaz:
https://doaj.org/article/23a0b8662e1f4cf7a49b25844d4df719
Autor:
Alicia M. Purkey, Mark L. Dell’Acqua
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 12 (2020)
Experience-dependent learning and memory require multiple forms of plasticity at hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type ionot
Externí odkaz:
https://doaj.org/article/ad2f308470754c95b93e11891e33fe9a
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 321-334 (2017)
Summary: Potentiation of synaptic strength relies on postsynaptic Ca2+ signals, modification of dendritic spine structure, and changes in gene expression. One Ca2+ signaling pathway supporting these processes routes through L-type Ca2+ channels (LTCC
Externí odkaz:
https://doaj.org/article/96f0152f32fc42d2830f557d040799ba
Autor:
Angela R. Wild, Brooke L. Sinnen, Philip J. Dittmer, Matthew J. Kennedy, William A. Sather, Mark L. Dell’Acqua
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3537-3550.e4 (2019)
Summary: Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range s
Externí odkaz:
https://doaj.org/article/6ce51fc0392c409f9aedb860a58b1965
Autor:
Kevin C. Crosby, Sara E. Gookin, Joshua D. Garcia, Katlin M. Hahm, Mark L. Dell’Acqua, Katharine R. Smith
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3284-3297.e3 (2019)
Summary: Inhibitory synapses mediate the majority of synaptic inhibition in the brain, thereby controlling neuronal excitability, firing, and plasticity. Although essential for neuronal function, the central question of how these synapses are organiz
Externí odkaz:
https://doaj.org/article/177e5de8518b4b4f9459c49e82a08221