Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mark Kerstjens"'
Autor:
Pauline Schneider, Patricia Garrido Castro, Sandra M. Pinhanços, Mark Kerstjens, Eddy H. vanRoon, Anke H.W. Essing, M. Emmy M. Dolman, Jan J. Molenaar, Rob Pieters, Ronald W. Stam
Publikováno v:
eJHaem, Vol 1, Iss 2, Pp 527-536 (2020)
Abstract MLL‐rearranged acute lymphoblastic leukemia (ALL) represents a highly aggressive ALL subtype, characterized by aberrant DNA methylation patterns. DNA methyltransferase inhibitors, such as decitabine have previously been demonstrated to be
Externí odkaz:
https://doaj.org/article/17ab3a3cd77a4a4f9267630c85d65ee2
Autor:
Priscilla Wander, Susan T. C. J. M. Arentsen-Peters, Kirsten S. Vrenken, Sandra Mimoso Pinhanҫos, Bianca Koopmans, M. Emmy M. Dolman, Luke Jones, Patricia Garrido Castro, Pauline Schneider, Mark Kerstjens, Jan J. Molenaar, Rob Pieters, Christian Michel Zwaan, Ronald W. Stam
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 638 (2022)
KMT2A-rearranged acute lymphoblastic leukemia (ALL) in infants (KMT2A-rearranged infant ALL patient samples (n = 2). The most effective drugs were then tested on non-leukemic whole bone marrow samples (n = 2) to select drugs with a favorable therapeu
Externí odkaz:
https://doaj.org/article/7815cb20aae54d3d99175e3e8348e9d7
Autor:
Mark Kerstjens, Patricia Garrido Castro, Sandra S. Pinhanços, Pauline Schneider, Priscilla Wander, Rob Pieters, Ronald W. Stam
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 711 (2021)
Acute lymphoblastic leukemia (ALL) in infants (MLL (or KMT2A) gene, which confer highly dismal prognoses on current combination chemotherapeutic regimens. Hence, more adequate therapeutic strategies are urgently needed. To expedite clinical transitio
Externí odkaz:
https://doaj.org/article/8ca0d87c0f0c463c97350d6b693d337c
Autor:
Mark Kerstjens, Sandra S. Pinhancos, Patricia Garrido Castro, Pauline Schneider, Priscilla Wander, Rob Pieters, Ronald W. Stam
Publikováno v:
Haematologica, Vol 103, Iss 4 (2018)
Externí odkaz:
https://doaj.org/article/d3f95283552c4d929204a330ddd3b6bf
Autor:
M. Emmy M. Dolman, Jan J. Molenaar, Kelly C. Goldsmith, Jan Koster, Ronald W. Stam, Mark Kerstjens, David A. Egan, Daphne Lelieveld, Linda Schild, Nil A. Schubert, Hunter C. Jonus, Bianca Koopmans, Jasmine Y. Lee, Lindy K. Alles, Laurel T. Bate-Eya, Lindy Vernooij
Supplementary data including supplementary figures S1 to S6 and supplementary tables S1 to S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c19a6188349cc1e7ae304543adf5a25
https://doi.org/10.1158/1535-7163.22522524
https://doi.org/10.1158/1535-7163.22522524
Autor:
M. Emmy M. Dolman, Jan J. Molenaar, Kelly C. Goldsmith, Jan Koster, Ronald W. Stam, Mark Kerstjens, David A. Egan, Daphne Lelieveld, Linda Schild, Nil A. Schubert, Hunter C. Jonus, Bianca Koopmans, Jasmine Y. Lee, Lindy K. Alles, Laurel T. Bate-Eya, Lindy Vernooij
Supplementary information on the used materials and methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737308f3d4a0e5a27d921f6744ac9ebf
https://doi.org/10.1158/1535-7163.22522521.v1
https://doi.org/10.1158/1535-7163.22522521.v1
Data from Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4+ Infant ALL
Autor:
Gianni Cazzaniga, Andrea Biondi, Rob Pieters, Ronald W. Stam, Giuseppe Basso, Geertruy Te Kronnie, Rab K. Prinjha, Nicholas Smithers, Mark Kerstjens, Eddy H.J. Van Roon, Grazia Fazio, Patricia Garrido Castro, Angela M. Savino, Margherita Vieri, Francesca Rizzo, Luca Trentin, Michela Bardini
MLL-rearranged acute lymphoblastic leukemia (ALL) occurring in infants is a rare but very aggressive leukemia, typically associated with a dismal prognosis. Despite the development of specific therapeutic protocols, infant patients with MLL-rearrange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f58741275371233589698b39895095
https://doi.org/10.1158/1535-7163.c.6539490
https://doi.org/10.1158/1535-7163.c.6539490
Autor:
Gianni Cazzaniga, Andrea Biondi, Rob Pieters, Ronald W. Stam, Giuseppe Basso, Geertruy Te Kronnie, Rab K. Prinjha, Nicholas Smithers, Mark Kerstjens, Eddy H.J. Van Roon, Grazia Fazio, Patricia Garrido Castro, Angela M. Savino, Margherita Vieri, Francesca Rizzo, Luca Trentin, Michela Bardini
Supplementary Methods: provide additional information about the methods used in the present study; Supplementary Figure S1: refers to apoptosis analysis of patients-derived xenograft samples exposed to IBET151 ex vivo; Supplementary Figure S2: report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839d380f218b8fadea99c5caa872c7fc
https://doi.org/10.1158/1535-7163.22510059
https://doi.org/10.1158/1535-7163.22510059
Autor:
M. Emmy M. Dolman, Jan J. Molenaar, Kelly C. Goldsmith, Jan Koster, Ronald W. Stam, Mark Kerstjens, David A. Egan, Daphne Lelieveld, Linda Schild, Nil A. Schubert, Hunter C. Jonus, Bianca Koopmans, Jasmine Y. Lee, Lindy K. Alles, Laurel T. Bate-Eya, Lindy Vernooij
Neuroblastoma tumors frequently overexpress the anti-apoptotic protein B-cell lymphoma/leukemia 2 (BCL-2). We previously showed that treating BCL-2–dependent neuroblastoma cells with the BCL-2 inhibitor venetoclax results in apoptosis, but unfortun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94290ce21ef15de16b10560ee4307a2
https://doi.org/10.1158/1535-7163.c.6543414.v1
https://doi.org/10.1158/1535-7163.c.6543414.v1
Autor:
Ronald W. Stam, M. Emmy M. Dolman, Anke H. W. Essing, Pauline Schneider, Mark Kerstjens, Rob Pieters, P. Castro, Jan J. Molenaar, Sandra S Mimoso Pinhancos, Eddy H.J. van Roon
Publikováno v:
eJHaem. 1:527-536
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f7019de76379a12def59d98c8470b36
https://doi.org/10.1002/jha2.81
https://doi.org/10.1002/jha2.81