Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mark Kenney"'
Autor:
Richard D. Bell, Matthew Brendel, Maxwell A. Konnaris, Justin Xiang, Miguel Otero, Mark A. Fontana, Zilong Bai, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Daria M. Krenitsky, Nida Meednu, Javier Rangel-Moreno, Dagmar Scheel-Toellner, Hayley Carr, Saba Nayar, Jack McMurray, Edward DiCarlo, Jennifer H. Anolik, Laura T. Donlin, Dana E. Orange, H. Mark Kenney, Edward M. Schwarz, Andrew Filer, Lionel B. Ivashkiv, Fei Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Rheumatoid arthritis (RA) is a complex immune-mediated inflammatory disorder in which patients suffer from inflammatory-erosive arthritis. Recent advances on histopathology heterogeneity of RA synovial tissue revealed three distinct phenotyp
Externí odkaz:
https://doaj.org/article/b17d2655ca764faea6b9cae2cefd3a7a
Publikováno v:
JAAD Case Reports, Vol 41, Iss , Pp 26-29 (2023)
Externí odkaz:
https://doaj.org/article/a47d9b53fdc64e30b89fc3231f608b19
Autor:
H Mark Kenney, Kiana L Chen, Lindsay Schnur, Jeffrey I Fox, Ronald W Wood, Lianping Xing, Christopher T Ritchlin, Homaira Rahimi, Edward M Schwarz, Hani A Awad
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0305623 (2024)
BackgroundDevelopment of reliable disease activity biomarkers is critical for diagnostics, prognostics, and novel drug development. Although computed tomography (CT) is the gold-standard for quantification of bone erosions, there are no consensus app
Externí odkaz:
https://doaj.org/article/e5c2e52c752f405ea8310305a7bf736a
Autor:
Yue Peng, H. Mark Kenney, Karen L. de Mesy Bentley, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectiveInflammatory-erosive arthritis is exacerbated by dysfunction of joint-draining popliteal lymphatic vessels (PLVs). Synovial mast cells are known to be pro-inflammatory in rheumatoid arthritis (RA). In other settings they have anti-inflammato
Externí odkaz:
https://doaj.org/article/80288ec9980c44ea93b144bd10879db1
Autor:
H. Mark Kenney, Ronald W. Wood, Gabriel Ramirez, Richard D. Bell, Kiana L. Chen, Lindsay Schnur, Homaira Rahimi, Benjamin D. Korman, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz, Calvin L. Cole
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-16 (2023)
Abstract Background Although treatment options and algorithms for rheumatoid arthritis (RA) have improved remarkably in recent decades, there continues to be no definitive cure or pharmacologic intervention with reliable long-term efficacy. For this
Externí odkaz:
https://doaj.org/article/19b87fe1e574417196fd3fe8ae9f637d
Autor:
H. Mark Kenney, Javier Rangel-Moreno, Yue Peng, Kiana L. Chen, Jennifer Bruno, Abdul Embong, Elizabeth Pritchett, Jeffrey I. Fox, Enrique Becerril-Villanueva, Armando Gamboa-Domínguez, Sally Quataert, Gowrishankar Muthukrishnan, Ronald W. Wood, Benjamin D. Korman, Jennifer H. Anolik, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz, Chia-Lung Wu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionDefective lymphatic drainage and translocation of B-cells in inflamed (Bin) joint-draining lymph node sinuses are pathogenic phenomena in patients with severe rheumatoid arthritis (RA). However, the molecular mechanisms underlying this ly
Externí odkaz:
https://doaj.org/article/60bcac2b046f4b6fa2b4cb7c08b2c6e3
Autor:
H. Mark Kenney, Yue Peng, Richard D. Bell, Ronald W. Wood, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract While rheumatoid arthritis patients and tumor necrosis factor transgenic (TNF-Tg) mice with inflammatory-erosive arthritis display lymphatic drainage deficits, the mechanisms responsible remain unknown. As ultrastructural studies of joint-dr
Externí odkaz:
https://doaj.org/article/5175e6c058f84893b81325cb3d0f315f
Autor:
H. Mark Kenney, Chia-Lung Wu, Alayna E. Loiselle, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-20 (2022)
Abstract Background Lymphatic dysfunction exists in tumor necrosis factor transgenic (TNF-Tg) mice and rheumatoid arthritis (RA) patients. While joint-draining TNF-Tg popliteal lymphatic vessels (PLVs) have deficits in contractility during end-stage
Externí odkaz:
https://doaj.org/article/4e1ae8c2a72c4427a3e1df0e23045f60
Autor:
Maria de la Luz Garcia-Hernandez, Javier Rangel-Moreno, Maricela Garcia-Castaneda, H. Mark Kenney, Ananta Paine, Michael Thullen, Allen P. Anandarajah, Edward M. Schwarz, Robert T. Dirksen, Christopher T. Ritchlin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectiveDendritic Cell-Specific Transmembrane Protein (DC-STAMP) is essential for the formation of fully functional multinucleated osteoclasts. DC-STAMP deficient mice, under physiological conditions, exhibit osteopetrosis and develop systemic autoi
Externí odkaz:
https://doaj.org/article/8f55d9fd829f440daa95fdd03dfcd3fe
Autor:
H. Mark Kenney, Yue Peng, Kiana L. Chen, Raquel Ajalik, Lindsay Schnur, Ronald W. Wood, Edward M. Schwarz, Hani A. Awad
Publikováno v:
Bone Reports, Vol 16, Iss , Pp 101167- (2022)
Introduction: Micro-computed tomography (μCT) is a valuable imaging modality for longitudinal quantification of bone volumes to identify disease or treatment effects for a broad range of conditions that affect bone health. Complex structures, such a
Externí odkaz:
https://doaj.org/article/37ab4d2aae024d879b113243110fdcde