Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mark Kagan"'
Autor:
Lydia Wang-Lakshman, Gian Camenisch, Helen Gu, Jin Chen, Lai Wang, Mark Kagan, Jessie Gu, Markus Walles, Heidi J. Einolf, Elizabeth McNamara, Ralph Woessner, Zhuang Miao
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 49(7)
Tropifexor (NVP-LJN452) is a highly potent, selective, non-steroidal, non-bile acid farnesoid X receptor (FXR) agonist for the treatment of nonalcoholic steatohepatitis (NASH). Its absorption, metabolism, and excretion was studied following a 1-mg or
Autor:
Cornelis E. C. A. Hop, Swapan Chowdhury, Douglas K. Spracklin, Simone Schadt, Christoph Funk, W. Griffith Humphreys, Angus N. R. Nedderman, Fumihiko Igarashi, Josh Yuan, Chandra Prakash, Frank Runge, Holger Scheible, Mark Kagan, S. Cyrus Khojasteh, Piet Swart, R. Scott Obach, Bojan Bister, Alexander David James, Susanna Tse
Publikováno v:
BASE-Bielefeld Academic Search Engine
Since the introduction of metabolites in safety testing (MIST) guidance by the Food and Drug Administration in 2008, major changes have occurred in the experimental methods for the identification and quantification of metabolites, ways to evaluate co
Autor:
Parasar Pal, Ralph Matott, Sam Rebello, Surya Ayalasomayajula, Gangadhar Sunkara, Tapan Majumdar, Anne Crissey, Charles D. Meyers, Jing Yu, Jin Chen, Zhenzhong Su, Mark Kagan
Publikováno v:
Biopharmaceutics & Drug Disposition. 36:452-461
Pradigastat, a diacylglycerol acyltransferase 1 inhibitor, is being developed for the treatment of familial chylomicronemia syndrome. The results of two studies that evaluated the effect of food on the oral bioavailability of pradigastat using random
Publikováno v:
Kagan, M S, van der Ploeg, F & Withagen, C A A M 2015, ' Battle for Climate and Scarcity Rents: Beyond the Linear-Quadratic Case ', Dynamic Games and Applications, vol. 5, no. 4, pp. 493-522 . https://doi.org/10.1007/s13235-015-0154-2
Dynamic Games and Applications, 5(4), 493-522. Springer Science + Business Media
Dynamic Games and Applications
Dynamic Games and Applications, 5(4), 493-522. Springer Science + Business Media
Dynamic Games and Applications
Industria imports oil, produces final goods and wishes to mitigate global warming. Oilrabia exports oil and buys final goods from the other country. Industria uses the carbon tax to impose an import tariff on oil and steal some of Oilrabia's scarcity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6de98aa8c989aeac7a8d23a5f2d7a4
https://research.vu.nl/en/publications/35809dbe-b8aa-4d30-82e3-378dc942eef5
https://research.vu.nl/en/publications/35809dbe-b8aa-4d30-82e3-378dc942eef5
Autor:
Surya P, Ayalasomayajula, Charles D, Meyers, Jing, Yu, Mark, Kagan, Ralph, Matott, Parasar, Pal, Tapan, Majumdar, Zhenzhong, Su, Anne, Crissey, Sam, Rebello, Gangadhar, Sunkara, Jin, Chen
Publikováno v:
Biopharmaceuticsdrug disposition. 36(7)
Pradigastat, a diacylglycerol acyltransferase 1 inhibitor, is being developed for the treatment of familial chylomicronemia syndrome. The results of two studies that evaluated the effect of food on the oral bioavailability of pradigastat using random
Autor:
Mark Kagan
Despite overwhelming scientific evidence for man-made climate change, many people remain skeptical. While this phenomenon of `climate-skepticism' prevents implementation of environmental policies around the globe, it is ignored in economic models of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7419366bf4c8862cfc0b8ea3d14f1d57
http://papers.tinbergen.nl/12112.pdf
http://papers.tinbergen.nl/12112.pdf
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 40(9)
The metabolism, pharmacokinetics, and excretion of [(14)C]indacaterol were investigated in healthy male subjects. Although indacaterol is administered to patients via inhalation, the dose in this study was administered orally. This was done to avoid
Publikováno v:
Cancer chemotherapy and pharmacology. 70(4)
Elucidating the metabolic profile of anticancer agent panobinostat is essential during drug development. Disposition, metabolism, and excretion profiles were characterized using trace radiolabeled (14)C-panobinostat in four patients with advanced can
Autor:
Stephen S. Hecht, Shobha A. Akerkar, Mark Kagan, Peter G. Foiles, Steven G. Carmella, Gary D. Stoner, James H. Resau
Publikováno v:
Chemical Research in Toxicology. 4:364-368
A gas chromatography, negative ion chemical ionization mass spectrometry (GC-NICI-MS) based assay for tobacco-specific nitrosamine adducts of DNA is described. The assay is based on the observation that acid hydrolysis of DNA from animals treated wit
Publikováno v:
Blood. 122:4011-4011
Background There is a growing tendency for drugs to be grouped according to their perceived ‘class effects’, regardless of the different pharmacological profiles of the parent drugs and of their metabolites. Imatinib, dasatinib, nilotinib, bosuti