Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mark K Haynes"'
Autor:
Kishore Polireddy, Mohiuddin Md Taimur Khan, Hemantkumar Chavan, Susan Young, Xiaochao Ma, Anna Waller, Matthew Garcia, Dominique Perez, Stephanie Chavez, Jacob J Strouse, Mark K Haynes, Cristian G Bologa, Tudor I Oprea, George P Tegos, Larry A Sklar, Partha Krishnamurthy
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40005 (2012)
ABCB6 is a member of the adenosine triphosphate (ATP)-binding cassette family of transporter proteins that is increasingly recognized as a relevant physiological and therapeutic target. Evaluation of modulators of ABCB6 activity would pave the way to
Externí odkaz:
https://doaj.org/article/47f376b04fb948fba53161f649e4c7f5
Autor:
David Barrett, Meghan Wyatt, Haim Bar, Mark K. Haynes, Bruce S. Edwards, Larry A. Sklar, Adam Zweifach
Publikováno v:
SLAS Discovery, Vol 27, Iss 5, Pp 314-322 (2022)
The solid tumor microenvironment (TME) suppresses immune responses. Three alterations in the TME converge on a pathway triggered by elevated cyclic AMP (cAMP) that suppresses T cell receptor (TCR) signaling. We developed a phenotypic assay to screen
Externí odkaz:
https://doaj.org/article/cd239189b37c4c4296a91e5340d47196
Autor:
Miguel Alejandro Lopez‐Ramirez, Sara McCurdy, Wenqing Li, Mark K. Haynes, Preston Hale, Karol Francisco, Killian Oukoloff, Matthew Bautista, Chelsea H.J. Choi, Hao Sun, Brendan Gongol, John Y. Shyy, Carlo Ballatore, Larry A. Sklar, Alexandre R. Gingras
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 5, Pp 334-355 (2021)
ABSTRACT The transmembrane protein heart of glass1 (HEG1) directly binds to and recruits Krev interaction trapped protein 1 (KRIT1) to endothelial junctions to form the HEG1–KRIT1 protein complex that establishes and maintains junctional integrity.
Externí odkaz:
https://doaj.org/article/12d216681c9e4a0d9063a1dd1f6e713e
Autor:
Robert J. Lake, Kostiantyn Dreval, Larry A. Sklar, Mark K. Haynes, Rabeya Bilkis, Hua-Ying Fan
Publikováno v:
SLAS Discov
Notch signaling is often involved in cancer cell initiation and proliferation. Aberrant Notch activation underlies more than 50% of T-cell Acute Lymphoblastic Leukemia (T-ALL); accordingly, chemicals disrupting Notch signaling are of potential to tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a85e5cdc8d2a8f341bfc33f6f88569
https://pubmed.ncbi.nlm.nih.gov/32567455
https://pubmed.ncbi.nlm.nih.gov/32567455
Autor:
Oleg Ursu, Yinan Wang, Anna Waller, Larry A. Sklar, Barry P. Sleckman, Andrea L. Bredemeyer, Mark K. Haynes, Bruce S. Edwards, Abigail J Morales
Publikováno v:
SLAS Discovery. 23:624-633
DNA double strand breaks (DSBs) are repaired primarily by homologous recombination (HR) or non-homologous end joining (NHEJ). Compounds that modulate HR have shown promise as cancer therapeutics. The V(D)J recombination reaction, which assembles anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18732b07d8808bdfd39207eb985a0368
https://doi.org/10.1177/2472555217746324
https://doi.org/10.1177/2472555217746324
Autor:
Miguel Alejandro Lopez-Ramirez, John Y.-J. Shyy, Mark K. Haynes, Larry A. Sklar, Alexandre R. Gingras, Killian Oukoloff, Preston Hale, Carlo Ballatore, Matthew Bautista, Brendan Gongol
The Krüppel-like Factors 4 and 2 (KLF4/2) are transcription factors and master regulators of endothelial cells (ECs) phenotype and homeostasis. KLF4/2 are important blood-flow-responsive genes within ECs that differentially regulate the expression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bba41849d0cceb65bb64550ce04f6a7
https://doi.org/10.1101/744821
https://doi.org/10.1101/744821
Autor:
Li Luo, T Fabiola Miscioscia, Jake Strouse, Charuta C. Palsuledesai, Susan Young, Cristian Bologa, Harold A. Ames, Ramona Curpan, Orazio Nicolotti, Tudor I. Oprea, Bruce S. Edwards, Angela Wandinger-Ness, Virginia M. Salas, Zhanna Galochkina, Oleg Ursu, Anna Waller, Mark B. Carter, Yuna Guo, Mark K. Haynes, Larry A. Sklar, Zurab Surviladze, Elsa Romero, Yang Wu, Terry D. Foutz
Publikováno v:
ACS chemical biology. 13(6)
Ras and Ras-related small GTPases are key regulators of diverse cellular functions that impact cell growth, survival, motility, morphogenesis, and differentiation. They are important targets for studies of disease mechanisms as well as drug discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b4e73bea64eddf8a45bba74a3d88c7
https://pubmed.ncbi.nlm.nih.gov/29746086
https://pubmed.ncbi.nlm.nih.gov/29746086
Autor:
Mark K, Haynes, Matthew, Garcia, Ryan, Peters, Anna, Waller, Pietro, Tedesco, Oleg, Ursu, Cristian G, Bologa, Radleigh G, Santos, Clemencia, Pinilla, Terry H, Wu, Julie A, Lovchik, Tudor I, Oprea, Larry A, Sklar, George P, Tegos
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1700
The resistance nodulation cell division (RND) family of proteins are inner membrane transporters that associate with periplasmic adaptor proteins and outer membrane porins to affect substrate transport from the cytosol and periplasm in Gram-negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91bdc72fb845ee07725fea0b9cc603e3
https://pubmed.ncbi.nlm.nih.gov/29177837
https://pubmed.ncbi.nlm.nih.gov/29177837
Autor:
Anna Waller, Cristian Bologa, Tudor I. Oprea, Clemencia Pinilla, Radleigh G. Santos, Pietro Tedesco, Ryan Peters, Matthew Garcia, Terry H. Wu, Mark K. Haynes, Julie A. Lovchik, Larry A. Sklar, George P. Tegos, Oleg Ursu
Publikováno v:
Methods in Molecular Biology ISBN: 9781493974528
The resistance nodulation cell division (RND) family of proteins are inner membrane transporters that associate with periplasmic adaptor proteins and outer membrane porins to affect substrate transport from the cytosol and periplasm in Gram-negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::289440a0dbcb4570833ae4e95ef97e56
https://doi.org/10.1007/978-1-4939-7454-2_16
https://doi.org/10.1007/978-1-4939-7454-2_16
Autor:
Robert E. Sammelson, Micaleah Newman, Christopher R. Fullenkamp, Rachel R. Pelly, Larry A. Sklar, Sarah Komanapalli, Evan M. Niemeier, Heather A. Bruns, Derron L. Bishop, Ashley N. Zahrt, Katie M. Reed, Lindy M. Caffo, Susan A. McDowell, Diana Cordero, Mark K. Haynes
Publikováno v:
Current Pharmaceutical Biotechnology. 15:727-737
Staphylococcus aureus is a leading causative agent in sepsis, endocarditis, and pneumonia. An emerging concept is that prognosis worsens when the infecting S. aureus strain has the capacity to not only colonize tissue as an extracellular pathogen, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccc678d8aee5cd5e68b756b8fda6a3a
https://doi.org/10.2174/1389201015666140909124310
https://doi.org/10.2174/1389201015666140909124310