Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mark James Bamford"'
Autor:
Angela Bridges, Sandrine Jayne, Jennifer Schofield, Ana Sousa Manso, Duncan S. Holmes, Xi-Ping Zhang, Larissa Lezina, Michael T. McCabe, Mark James Bamford, Anastasia Wyce, David Jonathan Hirst, Máire A. Convery, Tom Slocombe, Andrew C. Pearce, Don O. Somers, Simon D. Wagner, Paul Scott-Stevens, Ann Louise Walker, Jonathan P. Hutchinson, Constantinos Demetriou, Cassie Messenger, Melissa C. Musso, Sian Evans, Ruth C. Barber, Joanne Morley, Thomas Gobbetti
Publikováno v:
The Journal of Biological Chemistry
B-cell lymphoma 6 (BCL6) is a zinc finger transcriptional repressor possessing a BTB–POZ (BR-C, ttk, and bab for BTB; pox virus and zinc finger for POZ) domain, which is required for homodimerization and association with corepressors. BCL6 has mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c7e6fdf77eb69b9270c5b0a66260fc
https://doi.org/10.1016/j.jbc.2021.100928
https://doi.org/10.1016/j.jbc.2021.100928
Autor:
Richard G. Compton, Laura H. Mace, Jessica Y. K. Chiu, Mark James Bamford, Peter Tomčík, Timothy J. Donohoe, Osamu Ichihara, Jason S. Rodrigues, Rhian E. Thomas, Craig E. Banks, Dale J. Johnson
This paper reports a study into the partial reduction of N-alkylpyridinium salts together with subsequent elaboration of the intermediates thus produced. Activation of a pyridinium salt by placing an ester group at C-2, allows the addition of two ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e348b723f298a0d4e26274abe62ecd
https://doi.org/10.1039/b517462g
https://doi.org/10.1039/b517462g
Autor:
Beverley Smith, Alessandra Gaiba, Jon Graham Anthony Steadman, Penelope C. Staton, Antoinette Naylor, David Matthew Wilson, Robert P. Davis, Susannah Davies, Tania O. Stean, Alastair D. Reith, Mark James Bamford, Christopher A. Parr, David Kenneth Dean, Frank D. King, Andrew K. Takle, Elaine A. Irving, Alison M. Ray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4373-4376
Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af69a9ad5d1b9c75f481ac4e3fb01bc5
https://doi.org/10.1016/j.bmcl.2008.06.070
https://doi.org/10.1016/j.bmcl.2008.06.070
Autor:
Robert Lafferty, Tracey Yi, Ross G. Bentley, Dennis Lee, Sanjay S. Khandekar, Christine Webb, Joseph P. Marino, Mark James Bamford, Gary K. Smith, Erding Hu, Robert N. Willette, Zunxuan Chen, Robert B. Kirkpatrick, Eugene T. Grygielko, Robert A. Stavenger, David J. Behm, Larry J. Jolivette, Lois L. Wright, David Kendall Jung, Terry Panchal, Chris P. Doe, Edward Dul
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:89-98
Increased Rho kinase (ROCK) activity contributes to smooth muscle contraction and regulates blood pressure homeostasis. We hypothesized that potent and selective ROCK inhibitors with novel structural motifs would help elucidate the functional role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dce38430c139758cf6d25985f84a50d
https://doi.org/10.1124/jpet.106.110635
https://doi.org/10.1124/jpet.106.110635
Autor:
James T. Townsend, Alessandra Gaiba, David Kendall Jung, Christopher A. Parr, John D. Harling, David Matthew Wilson, Mark James Bamford, Stephen L. Garland, Susannah Davies, Nicholas Bailey, Jason Witherington, Michael J. Alberti, Andrew K. Takle, David Kenneth Dean, Jon Graham Anthony Steadman, Terence A. Panchal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3402-3406
A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a34ec33bd554df8f96b52fc1d339b5
https://doi.org/10.1016/j.bmcl.2005.05.021
https://doi.org/10.1016/j.bmcl.2005.05.021
Autor:
Mark James Bamford, Andrew R. Calver, David Matthew Wilson, Rebecca K. Davis, Nicholas Bailey, Isabel Jm Beresford, Jason Witherington, Susannah Davis, Jon Graham Anthony Steadman, Phillip Jeffrey, Vicky Holland, Joanne Schogger, Christopher A. Parr, Jeffrey Wald, Teresa Heslop, Michael A. Briggs, Terrance A. Panchal, Leanne Harris, Andrew D. Medhurst, Kim Brackenborough, David Kenneth Dean, Tania O. Stean, Brenda K. Trail, Nigel Quashie, Angela Worby, Stephen J. Brough, Barry Crook, James Apps, Andrew K. Takle, Robert P. Davis, Sanjeet Singh Sehmi
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
This Letter describes the discovery of GSK189254 and GSK239512 that were progressed as clinical candidates to explore the potential of H3 receptor antagonists as novel therapies for the treatment of Alzheimer's disease and other dementias. By careful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e541fa0f8606fd8aa20c773c236c2d64
https://pubmed.ncbi.nlm.nih.gov/24269482
https://pubmed.ncbi.nlm.nih.gov/24269482
Autor:
Angela Worby, Mark James Bamford, David Matthew Wilson, Christopher A. Parr, Susannah Davis, Andrew R. Calver, James Apps, Andrew D. Medhurst, Brenda K. Trail, Andrew K. Takle, David Kenneth Dean, Michael A. Briggs, Tom D. Heightman, Trevor White, Isabel Jm Beresford, Tania O. Stean, Robert P. Davis, Sanjeet Singh Sehmi, Terry Panchal, Leanne Harris, Nigel Quashie, Barry Crook, Jon Graham Anthony Steadman, Jason Witherington, Joanne Schogger, Nicholas Bailey
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
This Letter describes the discovery of a novel series of H3 receptor antagonists. The initial medicinal chemistry strategy focused on deconstructing and simplifying an early screening hit which rapidly led to the discovery of a novel series of H3 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f2df3198c9c47dfcdd310f42a1ed70
https://pubmed.ncbi.nlm.nih.gov/24161834
https://pubmed.ncbi.nlm.nih.gov/24161834
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4486253c5cce73293bf770d47d458644
https://doi.org/10.1002/chin.199149282
https://doi.org/10.1002/chin.199149282
Autor:
John Saunders, P. G. Wyatt, R. Storer, Mark James Bamford, Kevin N. Cobley, D. C. Orr, N.M. Gray, Michael M. Hann, Gordon G. Weingarten, B. E. V. Shenoy, Derek N. Evans, R. C. Bethell, D. C. Humber, Nicholas Cammack
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8229869a96809563d626b2114271b9eb
https://doi.org/10.1002/chin.199503261
https://doi.org/10.1002/chin.199503261
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ddba53cca16b443f12f4459ed3d29a9
https://doi.org/10.1002/chin.199532149
https://doi.org/10.1002/chin.199532149