Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Mark J. Zylka"'
Publikováno v:
F1000Research, Vol 12 (2024)
Background The open field assay is used to study anxiety-related traits and anxiolytic drugs in rodents. This assay entails measuring locomotor activity and time spent in the center of a chamber that is maintained at ambient room temperature. However
Externí odkaz:
https://doaj.org/article/e24c445c7f0644bcac26b833d627826a
Autor:
Wenxin Hu, Yun-Chung Hsiao, Nikolas Morrison-Welch, Sophia Lamberti, Chih-Wei Liu, Weili Lin, Stephanie M. Engel, Kun Lu, Mark J. Zylka
Publikováno v:
Heliyon, Vol 10, Iss 6, Pp e27980- (2024)
The study measured the levels of azoxystrobin (AZ) and thiabendazole (TBZ) in wallboards and metabolite levels of these fungicides in children. The paper covering of wallboard samples contained a higher concentration of AZ and TBZ than the gypsum cor
Externí odkaz:
https://doaj.org/article/8706b84bcb324501a1df7fae3fcae772
Publikováno v:
F1000Research, Vol 12 (2024)
Background The open field assay is used to study anxiety-related traits and anxiolytic drugs in rodents. This assay entails measuring locomotor activity and time spent in the center of a chamber that is maintained at ambient room temperature. However
Externí odkaz:
https://doaj.org/article/db345a6ead4e4f31b084e171a49e9555
Autor:
Lei Xing, Jeremy M. Simon, Travis S. Ptacek, Jason J. Yi, Lipin Loo, Hanqian Mao, Justin M. Wolter, Eric S. McCoy, Smita R. Paranjape, Bonnie Taylor-Blake, Mark J. Zylka
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112706- (2023)
Summary: The E3 ubiquitin ligase Ube3a is biallelically expressed in neural progenitors and glial cells, suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental disorders irrespective of parent of origin. Here, we engineered a
Externí odkaz:
https://doaj.org/article/e51c03b71c704840a187f7c84c88daee
Publikováno v:
FASEB BioAdvances, Vol 4, Iss 7, Pp 441-453 (2022)
Abstract Numerous autism spectrum disorder (ASD) risk genes are associated with Wnt signaling, suggesting that brain development may be especially sensitive to genetic perturbation of this pathway. Additionally, valproic acid, which modulates Wnt sig
Externí odkaz:
https://doaj.org/article/e60960da278b469e9b674b809db80ea0
Autor:
Jessica A. Jiménez, Jeremy M. Simon, Wenxin Hu, Sheryl S. Moy, Kathryn M. Harper, Chih-Wei Liu, Kun Lu, Mark J. Zylka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Hundreds of genes have been associated with autism spectrum disorder (ASD), including loss-of-function mutations in chromodomain helicase DNA binding protein 8 (Chd8). Environmental factors also are implicated in autism risk and have the pot
Externí odkaz:
https://doaj.org/article/04768033bf0245a198afb592fc2b8afe
Autor:
Jessica A. Jiménez, Mark J. Zylka
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 13, Iss 1, Pp 1-9 (2021)
Abstract Research with rodents is crucial for expanding our understanding of genetic and environmental risk factors for neurodevelopmental disorders (NDD). However, there is growing concern about the number of animal studies that are difficult to rep
Externí odkaz:
https://doaj.org/article/8c391d63d598430b874738b3480f49df
Autor:
Jessica A. Jiménez, Travis S. Ptacek, Alex H. Tuttle, Ralf S. Schmid, Sheryl S. Moy, Jeremy M. Simon, Mark J. Zylka
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-15 (2020)
Abstract Background Chromodomain helicase DNA-binding protein 8 (Chd8) is a high-confidence risk gene for autism spectrum disorder (ASD). However, how Chd8 haploinsufficiency impairs gene expression in the brain and impacts behavior at different stag
Externí odkaz:
https://doaj.org/article/ad6f601c36c849359209184c163a9e8d
Autor:
Giulia Fragola, Angela M. Mabb, Bonnie Taylor-Blake, Jesse K. Niehaus, William D. Chronister, Hanqian Mao, Jeremy M. Simon, Hong Yuan, Zibo Li, Michael J. McConnell, Mark J. Zylka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Topoisomerase 1 (TOP1) relieves DNA torsional stress during transcription and facilitates the expression of long neuronal genes. Here we show that deletion of Top1 in excitatory neurons leads to early onset neurodegeneration that is partially depende
Externí odkaz:
https://doaj.org/article/0fddde2332ce490c801aa1485380dfc3
Autor:
Jennifer Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to
Externí odkaz:
https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c