Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Mark J. S. Kelly"'
Publikováno v:
International Journal of Molecular Sciences, Vol 12, Iss 10, Pp 6469-6501 (2011)
Aerobic metabolism occurs in a background of oxygen radicals and reactive oxygen species (ROS) that originate from the incomplete reduction of molecular oxygen in electron transfer reactions. The essential role of aerobic metabolism, the generation a
Externí odkaz:
https://doaj.org/article/7eeb43b653994a1f90bb9841bad512f9
Autor:
Danielle L. Swaney, Christopher J.P. Mathy, Nevan J. Krogan, Tina Perica, Hannes Braberg, Yang Zhang, Noah Ollikainen, David G. Lambright, Tanja Kortemme, Jiewei Xu, Robyn M. Kaake, Gwendolyn Μ. Jang, Mark J. S. Kelly
Publikováno v:
Nature. 599:152-157
Molecular switch proteins whose cycling between states is controlled by opposing regulators1,2 are central to biological signal transduction. As switch proteins function within highly connected interaction networks3, the fundamental question arises o
The H3K4me3 chromatin modification, a hallmark of promoters of actively transcribed genes, is dynamically removed by the KDM5 family of histone demethylases. The KDM5 demethylases have a number of accessory domains, two of which, ARID and PHD1, lie b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d14356ec2e91de8f5a4bd935c85a8b
https://doi.org/10.1101/2022.01.13.476263
https://doi.org/10.1101/2022.01.13.476263
Autor:
Michael P. Czech, Tomás Rodríguez, Randall H. Friedline, Silvia Corvera, Raed Ibraheim, Lauren A. Tauer, Jason K. Kim, Kevin Luk, Sarah M. Nicoloro, Tiffany DeSouza, Lawrence M. Lifshitz, Anand Desai, Emmanouela Tsagkaraki, Xiaodi Hu, Felipe Henriques, Yuefei Shen, Nadia Amrani, Stacy Maitland, Mark J. S. Kelly, Scot A. Wolfe, Erik J. Sontheimer, Adilson L. Guilherme, Javier Solivan-Rivera
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Obesity and type 2 diabetes are associated with disturbances in insulin-regulated glucose and lipid fluxes and severe comorbidities including cardiovascular disease and steatohepatitis. Whole body metabolism is regulated by lipid-storing white adipoc
Autor:
Siobhan M. Craige, Shashi Kant, Roger J. Davis, Mark J. S. Kelly, Khanh-Van Tran, Marc R. Freeman, Heather Learnard, Kai Chen, Kasmir Ramo, John F. Keaney, Michaella M. Reif, Amada D. Caliz, Owen M. Peters
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Diseases related to impaired blood flow such as peripheral artery disease (PAD) impact nearly 10 million people in the United States alone, yet patients with clinical manifestations of PAD (e.g., claudication and limb ischemia) have limited treatment
Autor:
Xianlin Han, Meixia Pan, Nicole Wetoska, Michael A. Brehm, Matthew R. Hassler, Dimas Echeverria, Nicholas McHugh, Samuel R. Hildebrand, Mark J. S. Kelly, Batuhan Yenilmez, Julia F. Alterman, Lorenc Vangjeli, Kyounghee Min, Anastasia Khvorova, Chloe DiMarzio, Jacquelyn Sousa, Lawrence M. Lifshitz, Michael P. Czech
Publikováno v:
Molecular therapy. Nature Publishing Group
Nonalcoholic steatohepatitis (NASH) is a severe liver disorder characterized by triglyceride accumulation, severe inflammation, and fibrosis. With the recent increase in prevalence, NASH is now the leading cause of liver transplant, with no approved
Autor:
Kevin Luk, Tiffany De Souza, Nadia Amrani, Felipe Henriques, Lauren A. Tauer, Anand Desai, Randall H. Friedline, Stacy Maitland, Michael P. Czech, Sarah M. Nicoloro, Adilson L. Guilherme, Javier Solivan-Rivera, Silvia Corvera, Emmanouela Tsagkaraki, Mark J. S. Kelly, Jason K. Kim, Raed Ibraheim, Yuefei Shen, Scot A. Wolfe, Erik J. Sontheimer, Xiaodi Hu
Obesity and type 2 diabetes (T2D) are associated with poor tissue responses to insulin1,2, disturbances in glucose and lipid fluxes3–5 and comorbidities including steatohepatitis6 and cardiovascular disease7,8. Despite extensive efforts at preventi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34bc471291db98c32ff1baa1b3d75088
https://doi.org/10.1101/2020.10.13.337923
https://doi.org/10.1101/2020.10.13.337923
Autor:
Mark J. S. Kelly, Lin Liu, Michael C. Thompson, Xingjie Pan, Tanja Kortemme, Yang Zhang, James S. Fraser
Publikováno v:
Science (New York, N.Y.), vol 369, iss 6507
Science
Science
Exploring the design landscape Protein design typically selects a protein topology and then identifies the geometries (secondary-structure lengths and orientations) that give the most stable structures. A challenge for this approach is that functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1e93ee503d6084b4c87abe5071d72a
https://escholarship.org/uc/item/1pn2d40b
https://escholarship.org/uc/item/1pn2d40b
Autor:
Felipe Henriques, Shreya Kumar, Paul Cohen, Lawrence M. Lifshitz, Mark J. S. Kelly, Batuhan Yenilmez, Jiandie D. Lin, Alexander H. Bedard, Karl D. Bellve, Yetao Wang, Jeremy Luban, Adilson L. Guilherme, Jingyi Chi, Lee S. Weinstein, Leslie A. Rowland, Peng Zhang, Michael P. Czech
The “browning” of inguinal white adipose tissue (iWAT) through increased abundance of thermogenic beige/brite adipocytes is induced by cold exposure and many other perturbations in association with beneficial systemic metabolic effects. Adipose b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b60904e4e830634ef38d6c389bdbde5
https://doi.org/10.1101/2020.05.04.077529
https://doi.org/10.1101/2020.05.04.077529
Autor:
Gwendolyn M. Jang, Hannes Braberg, Jiewei Xu, Tina Perica, Christopher J.P. Mathy, Robyn M. Kaake, Mark J. S. Kelly, Yang Zhang, Nevan J. Krogan, Tanja Kortemme, David G. Lambright, Noah Ollikainen, Danielle L. Swaney
Molecular switches are central to signal transduction in protein interaction networks. One switch protein can independently regulate distinct cellular processes, but the molecular mechanisms enabling this functional multi-specificity remain unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d48dbb7f27171827db6f37f8adcc38
https://doi.org/10.1101/2020.01.04.893909
https://doi.org/10.1101/2020.01.04.893909