Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Mark J. Mulvihill"'
Autor:
Michael E. Stokes, Matthew D. Surman, Veronica Calvo, David Surguladze, An-Hu Li, Jennifer Gasparek, Matthew Betzenhauser, Guangyu Zhu, Hongwen Du, Alan C. Rigby, Mark J. Mulvihill
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2233 (2022)
The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) responsible for regulating protein synthesis and alleviating ER stress. PERK h
Externí odkaz:
https://doaj.org/article/bfdce10972624d15be3669c45666742f
Autor:
Lisa A. Marcaurelle, Mark J. Mulvihill
Publikováno v:
ACS Central Science, Vol 2, Iss 6, Pp 367-369 (2016)
Externí odkaz:
https://doaj.org/article/5c3299eac93841f0ae2402c8ce9fdee3
Autor:
Stéphanie Cunha, Yi-Chun Lin, Elizabeth A. Goossen, Christa I. DeVette, Mark R. Albertella, Stuart Thomson, Mark J. Mulvihill, Alana L. Welm
Publikováno v:
Cell Reports, Vol 6, Iss 1, Pp 141-154 (2014)
Metastasis is the major cause of death in cancer patients, yet the genetic and epigenetic programs that drive metastasis are poorly understood. Here, we report an epigenetic reprogramming pathway that is required for breast cancer metastasis. Concert
Externí odkaz:
https://doaj.org/article/c5c460c2ffbb46b78a441db65573d121
Publikováno v:
Oncology Reviews, Vol 7, Iss 1 (2013)
Based on over three decades of pre-clinical data, insulin-like growth factor-1 receptor (IGF-1R) signaling has gained recognition as a promoter of tumorogenesis, driving cell survival and proliferation in multiple human cancers. As a result, IGF-1R h
Externí odkaz:
https://doaj.org/article/76303b8ce97f40939d190ade26de5cdf
Autor:
Jonathan A. Pachter, Neil W. Gibson, Lee D. Arnold, Alexandra Eyzaguirre, Elizabeth Buck, Caroline Pirritt, Yan Yao, Matthew O'Connor, Gilda Mak, Lixin Feng, Andrew Cooke, Maryland Rosenfeld-Franklin, Mark J. Mulvihill, Qun-sheng Ji
Insulin-like growth factor-I receptor (IGF-IR) and its ligands, IGF-I and IGF-II, are up-regulated in a variety of human cancers. In tumors, such as colorectal, non–small cell lung, ovarian, and pediatric cancers, which may drive their own growth a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c6d78e18d5213a54ae84ba8a5326f5
https://doi.org/10.1158/1535-7163.c.6532205.v1
https://doi.org/10.1158/1535-7163.c.6532205.v1
Autor:
Jonathan A. Pachter, Neil W. Gibson, Lee D. Arnold, Alexandra Eyzaguirre, Elizabeth Buck, Caroline Pirritt, Yan Yao, Matthew O'Connor, Gilda Mak, Lixin Feng, Andrew Cooke, Maryland Rosenfeld-Franklin, Mark J. Mulvihill, Qun-sheng Ji
Supplementary Material from A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051a776eb2077a5803345e192cea0829
https://doi.org/10.1158/1535-7163.22486034.v1
https://doi.org/10.1158/1535-7163.22486034.v1
Autor:
Erik H. Heijne, Christopher D. Hupp, John W. Cuozzo, Anthony D. Keefe, Rob Winkel, L. Babiss, Wendy van Bruggen, Louis Renzetti, Mark J. Mulvihill, Birgit Zech, Andrew J. McRiner, Johan J. N. Veerman, Eddy Damen, Yorik B. Bruseker, Heather A. Thomson, Julie Liu, Gerhard Müller, Koen F. W. Hekking, Ying Zhang, Peter van Rijnsbergen
Publikováno v:
ACS Medicinal Chemistry Letters. 12:555-562
Herein we report the discovery of 2,4-1H-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a DNA-encoded chemical library (DE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d65527e5f7e8fb6d40ba9c6dda27029
https://doi.org/10.1021/acsmedchemlett.0c00547
https://doi.org/10.1021/acsmedchemlett.0c00547
Autor:
Michael E. Stokes, Veronica Calvo, Crissy Dudgeon, Sho Fujisawa, Sharon Huang, Leyi Shen, Nupur Ballal, Joe McGinley, David Liu, Mark J. Mulvihill, Alan C. Rigby, Nandita Bose, Eric S. Lightcap, David Surguladze
Publikováno v:
Cancer Research. 83:4010-4010
Anti-angiogenic agents form the backbone of standard of care for advanced clear cell renal cell carcinoma (ccRCC), but their clinical impact is limited by primary and secondary resistance mechanisms that remain a critical problem. Furthermore, the ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbcf75a59a556f335be5842688e24bf1
https://doi.org/10.1158/1538-7445.am2023-4010
https://doi.org/10.1158/1538-7445.am2023-4010
Autor:
Ari Nowacek, Julio A. Aguirre-Ghiso, Eduardo F. Farias, Alan C. Rigby, Mark J. Mulvihill, Ana Rita Nobre, Kirk A. Staschke, Veronica Calvo, Julie Cheung, Wei Zheng
The unfolded protein response (UPR) kinase PERK has been shown to serve as a survival factor for HER2-driven breast and prostate cancers as well as for dormant cancer cells. However, its role in metastasis is not understood. Here we found in the MMTV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b763329e3a51a1e822061dc31c6889e7
https://doi.org/10.1101/2021.07.30.454473
https://doi.org/10.1101/2021.07.30.454473
Autor:
Johan J N, Veerman, Yorik B, Bruseker, Eddy, Damen, Erik H, Heijne, Wendy, van Bruggen, Koen F W, Hekking, Rob, Winkel, Christopher D, Hupp, Anthony D, Keefe, Julie, Liu, Heather A, Thomson, Ying, Zhang, John W, Cuozzo, Andrew J, McRiner, Mark J, Mulvihill, Peter, van Rijnsbergen, Birgit, Zech, Louis M, Renzetti, Lee, Babiss, Gerhard, Müller
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein we report the discovery of 2,4-1H-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a DNA-encoded ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12d9ec47ec0b7cafcb9e7a681001f5ae
https://pubmed.ncbi.nlm.nih.gov/33859795
https://pubmed.ncbi.nlm.nih.gov/33859795