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pro vyhledávání: '"Mark J. Morris"'
Autor:
Debmalya Bhattacharyya, Gayan Mirihana Arachchilage, Soumitra Basu, Mark J. Morris, Katy M. Fedeli, Prakash Kharel
Publikováno v:
Biochimie. 137
RNA domain swapping typically demonstrates conservation of the native function of the domain in a non-native context. In contrast, we employed RNA engineering to demonstrate deviation of G-quadruplex (GQ) function that is contingent upon its context
Publikováno v:
Chem. Commun.. 50:1250-1252
An RNA G-quadruplex library was synthesised and screened against kanamycin A as the ligand. Naturally occurring G-quadruplex forming sequences that differentially bind to kanamycin A were identified and characterized. This provides a simple and effec
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 848
Nucleotide analog interference mapping (NAIM) is a quick and efficient method to define concurrently, yet singly, the importance of specific functional groups at particular nucleotide residues to the structure and function of an RNA. NAIM can be util
Publikováno v:
Nucleic Acids Research
We report that the cationic porphyrin TmPyP4, which is known mainly as a DNA G-quadruplex stabilizer, unfolds an unusually stable all purine RNA G-quadruplex (M3Q) that is located in the 5'-UTR of MT3-MMP mRNA. When the interaction between TmPyP4 and
Publikováno v:
Methods in Molecular Biology ISBN: 9781617795442
Nucleotide analog interference mapping (NAIM) is a quick and efficient method to define concurrently, yet singly, the importance of specific functional groups at particular nucleotide residues to the structure and function of an RNA. NAIM can be util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4783cadbebc38ed68031c660af3e5b5
https://doi.org/10.1007/978-1-61779-545-9_17
https://doi.org/10.1007/978-1-61779-545-9_17
Publikováno v:
Journal of the American Chemical Society. 132(50)
RNA G-quadruplexes located within the 5'-UTR of mRNA are almost always known to be associated with repression of cap-dependent translation. However, in this report we present functional as well as structural evidence that sequence redundancy in a G-r
Autor:
Soumitra Basu, Mark J. Morris
Publikováno v:
Biochemistry. 48(23)
MT3-MMP is a matrix metalloproteinase involved in the regulation of cancer cell invasion and metastasis. The MT3-MMP mRNA contains a 20-nucleotide G-rich region (M3Q) upstream of the initiation codon. Herein, we report that the M3Q purine-only sequen