Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Mark J. McKeage"'
Autor:
Catherine H. Han, Prashannata Khwaounjoo, Andrew G. Hill, Gordon M. Miskelly, Mark J. McKeage
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract This study evaluated the impact of calcium and magnesium on the in vitro degradation and in vivo clearance of oxaliplatin. Intact oxaliplatin and Pt(DACH)Cl2 were measured in incubation solutions by HPLC-UV. A clinical study determined chang
Externí odkaz:
https://doaj.org/article/4d56bc64c892498384d45ce82fe2a83d
Autor:
Daniel Dantzic, Pawan Noel, Fabrice Merien, Dong-Xu Liu, Jun Lu, Haiyong Han, Mark J. McKeage, Yan Li
Publikováno v:
Pharmaceutics, Vol 10, Iss 3, p 127 (2018)
Multidrug resistance (MDR) is a major hurdle which must be overcome to effectively treat cancer. ATP-binding cassette transporters (ABC transporters) play pivotal roles in drug absorption and disposition, and overexpression of ABC transporters has be
Externí odkaz:
https://doaj.org/article/bf4b69d1ff4e45cb8f43ad3058f774d6
Autor:
Alana Cavadino, Mark J. McKeage, Prashannata Khwaounjoo, J. Mark Elwood, Phyu Sin Aye, Sandar Tin Tin
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
BMC Cancer
BMC Cancer
Background Targeted treatment with Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitors (TKIs) is superior to systemic chemotherapy in non-small cell lung cancer (NSCLC) patients with EGFR gene mutations. Detection of EGFR mutations is
Publikováno v:
Targeted Oncology. 15:279-299
Epidermal growth factor receptor (EGFR) mutation testing is recommended for selecting patients with non-squamous non-small cell lung cancer (NSCLC) for EGFR tyrosine kinase inhibitor drug treatment. The objective of this article was to systematically
Autor:
Ikumi Tamai, Khine Myint, Yan Li, Fabrice Merien, Catherine H. Han, Johnson J. Liu, Mark J. McKeage, Stephen M. F. Jamieson, Takeo Nakanishi, Jun Lu, Nancy N. Jong, Christopher J. Squire, Riya Biswas
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Oxaliplatin is important for the clinical treatment of colorectal cancer and other gastrointestinal malignancies, but tumour resistance is limiting. Several oxaliplatin transporters were previously identified but their relative contributions to deter
Publikováno v:
Cancer Epidemiology. 57:24-32
Background Epidermal Growth Factor Receptor (EGFR) mutation testing is recommended for patients with non-squamous non-small cell lung cancer (NSCLC) but not all eligible patients get tested, which may bias the mutation prevalence estimated. This stud
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251357 (2021)
PLoS ONE
PLoS ONE
Background Non-squamous non-small cell lung cancer (NSCLC) patients with Epidermal Growth Factor Receptor (EGFR) mutation benefit from targeted treatments. Previous studies reported EGFR mutation-positive proportions among tested non-squamous NSCLC p
Autor:
Chun-Ming Tsai, Enriqueta Felip, Wu Chou Su, Manuel Cobo, Chong-Jen Yu, Kalyanee Viraswami-Appanna, Makoto Nishio, Zhe Chen, Alice T. Shaw, Vanessa Q. Passos, Tony Mok, Giorgio V. Scagliotti, David R. Spigel, Mark J. McKeage, Keunchil Park, Sergey Orlov
Publikováno v:
Scientia
Ceritinib; NSCLC; Fase II Ceritinib; NSCLC; Fase II Ceritinib; NSCLC; Phase II Introduction The phase II, single-arm ASCEND-3 study assessed the efficacy and safety of ceritinib in anaplastic lymphoma kinase (ALK) inhibitor (ALKi)–naive patients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cea816f421c19ffb8423c8a5f9c1f6
http://www.jto.org/article/S1556086419336603/pdf
http://www.jto.org/article/S1556086419336603/pdf
Autor:
M. Izquierdo, Anna Wrona, Dong Wook Kim, S-W. Kim, Mark J. McKeage, Alastair Greystoke, Kwang Bo Park, Andrea Ardizzoni, Scott A. Laurie, Marwan Ghosn, Gloria Borra, Byoung Chul Cho, Y. Wang, L. Wang
Publikováno v:
Journal of Thoracic Oncology. 16:S657-S658
Autor:
Angie Li, Christopher Lewis, J. Mark Elwood, Phyu Sin Aye, Nicola Kingston, Sandar Tin Tin, Phillip Shepherd, Mark J. McKeage, George Laking, Donald R. Love, Karen L. Sheath, Prashannata Khwaounjoo
Publikováno v:
Oncotarget
To investigate the clinical validity and utility of tests for detecting Epidermal Growth Factor Receptor (EGFR) gene mutations in non-squamous non-small cell lung cancer patients, tumour DNA extracts from 532 patients previously tested by the cobas E