Výsledky vyhledávání - "Mark J. Kraschnefski"

Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein

Autor: Andrea Bugarcic, Mark J. Kraschnefski, Fiona E. Fleming, Xing Yu, Mark von Itzstein, Helen Blanchard, Barbara S. Coulson

Publikováno v: Glycobiology. 19:194-200

The rotavirus spike protein VP4 mediates attachment to host cells and subsequent membrane penetration. The VP8(*) domain of VP4 forms the spike tips and is proposed to recognize host-cell surface glycans. For sialidase-sensitive rotaviruses such as r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9c39dac5186bbf1e535ed645c2896f
https://doi.org/10.1093/glycob/cwn119

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STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core

Autor: Mark von Itzstein, Milton J. Kiefel, Fiona E. Fleming, Martin Frank, Jeffrey Clifford Dyason, Alexander Jeffery Szyczew, Mark J. Kraschnefski, Gavan Holloway, Barbara S. Coulson, Helen Blanchard, Thomas Haselhorst

Publikováno v: Glycobiology. 17:68-81

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the N-acetylneuraminic acid (Neu5Ac) derivatives has been characterize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab706b40e42daf3a1ce4dad92ec7881
https://doi.org/10.1093/glycob/cwl051

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Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa

Autor: Helen Blanchard, Mark J. Kraschnefski, Stacy A. Scott, Gavan Holloway, Barbara S. Coulson, Mark von Itzstein

Publikováno v: Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 11)

Rotaviruses exhibit host-specificity and the first crystallographic information on a rotavirus strain that infects humans is reported here. Recognition and attachment to host cells, leading to invasion and infection, is critically linked to the funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6e4de06cbbcca576fee94492451943
https://pubmed.ncbi.nlm.nih.gov/16511215

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Akademický článek

Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein.

Autor: Mark J. Kraschnefski, Andrea Bugarcic, Fiona E. Fleming, Xing Yu, Mark von Itzstein, Barbara S. Coulson, Helen Blanchard

Publikováno v: Glycobiology; Mar2009, Vol. 19 Issue 3, p194-194, 1p

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