Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mark J. Huffman"'
Autor:
Thomas J. Connors, Jie Qian, Zeck Huang, Joanne R. Mathiasen, Edward R. Bacon, Thelma S. Angeles, Mark J. Huffman, Emir Duzic, Joseph M. Salvino, Beth Ann McKenna, Hervé Schaffhauser, Robert J. McHugh, Lily D. Lu, George C. Morton, Beverly P. Holskin, Karla Kopec, Amy DiCamillo, Gerard C. Rosse, Chrysanthe Spais, Rabindranath Tripathy, Lisa D. Aimone
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1421-1426
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Autor:
Beverly P. Holskin, Karla Kopec, Joanne R. Mathiasen, Amy DiCamillo, Babu G. Sundar, Thomas J. Connors, Emir Duzic, Edward R. Bacon, Gerard C. Rosse, Chrysanthe Spais, Thomas R. Bailey, Beth Ann McKenna, Rebecca A. Brown, Jie Qian, Derek Dunn, Mark J. Huffman, Joseph M. Salvino, Huang Zeqi, Lisa D. Aimone, Hervé Schaffhauser, Deborah Galinis, Thelma S. Angeles, Lily D. Lu, George C. Morton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:120-123
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Autor:
Rabindranath, Tripathy, Robert J, McHugh, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Zeck, Huang, Joanne R, Mathiasen, Amy, DiCamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Jie, Qian, Thelma S, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Emir, Duzic, Hervé, Schaffhauser, Gerard C, Rossé
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(3)
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Autor:
Babu G, Sundar, Thomas R, Bailey, Derek D, Dunn, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Huang, Zeqi, Joanne R, Mathiasen, Amy, Dicamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Rebecca, Brown, Jie, Qian, Thelma, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Deborah, Galinis, Emir, Duzic, Herve, Schaffhauser, Gerard C, Rosse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Autor:
Beth Ann McKenna, Mark J. Huffman, Hervé Schaffhauser, Lily D. Lu, Jie Qian, Amy DiCamillo, Joanne R. Mathiasen, Michael J. Marino
Publikováno v:
Biochemical pharmacology. 78(8)
Dimebolin (Dimebon), is a non-selective antihistamine approved in Russia for the treatment of allergy. Recently, this drug has been shown to be neuroprotective in cellular models of Alzheimer's disease and Huntington's disease, and to preserve cognit