Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mark J. Hickey"'
Autor:
Thomas R Ioerger, Theresa O'Malley, Reiling Liao, Kristine M Guinn, Mark J Hickey, Nilofar Mohaideen, Kenan C Murphy, Helena I M Boshoff, Valerie Mizrahi, Eric J Rubin, Christopher M Sassetti, Clifton E Barry, David R Sherman, Tanya Parish, James C Sacchettini
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75245 (2013)
Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis, especially given the increase of resistance worldwide to first- and second-line drugs. Because traditional target-based screening ha
Externí odkaz:
https://doaj.org/article/c0d9c992417546e4bc77aaa58b2066b1
Autor:
David R. Sherman, Tracey A. Day, Dmitry M. Shayakhmetov, Mark J. Hickey, John E. Mittler, Jennifer M. Pang, Molly R. Nixon, Reiling P. Liao, Maurine D. Miner, Cullen Thompson
Publikováno v:
Infection and Immunity. 82:5214-5222
The innate immune response plays an important but unknown role in host defense against Mycobacterium tuberculosis . To define the function of innate immunity during tuberculosis, we evaluated M. tuberculosis replication dynamics during murine infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c0fea5dd1d51b2ff62f1525f30de4d
https://doi.org/10.1128/iai.01340-13
https://doi.org/10.1128/iai.01340-13
Autor:
James E. Galagan, Jonathan M. Dreyfuss, Chris Mahwinney, Sahadevan Raman, Wen-Han Yu, Yang Liu, Robert P. Mohney, Julie Lamontagne, Irina Glotova, Hans-Joachim Mollenkopf, Linsday Sweet, Tige R. Rustad, Yves Van de Peer, Elham Azizi, Paul Drogaris, Julie Piquenot, Antonio L.C. Gomes, David R. Sherman, Diogo M. Camacho, Brent Honda, Christian Stolte, Adam D. Kennedy, Christopher D. Garay, Matthew W. Peterson, Kyle J. Minch, Thomas Abeel, Sang Tae Park, William Brabant, D. Branch Moody, Daniel Chelsky, Mark J. Hickey, Paul Iazzetti, Andrew S Krueger, Rene Allard, Brian Weiner, Anna Lyubetskaya, Jessica K. Winkler, Gary K. Schoolnik, Yiyong Zhou, Anca Dorhoi, Stefan H. E. Kaufmann, Peter Sisk, Jeremy Zucker, Suma Jaini, Gregory Dolganov
Publikováno v:
Nature. 499:178-183
We have taken the first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq and combined this reconstruction with system-wide profiling of messenger RNAs, proteins, metabolites and lipids dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463928289c82d4432e2d5d01342cdd9f
https://doi.org/10.1038/nature12337
https://doi.org/10.1038/nature12337
Autor:
Nathan D. Price, Jessica K. Winkler, Nitin S. Baliga, Chris Mawhinney, David J Reiss, Eliza J. R. Peterson, Shuyi Ma, David R. Sherman, Bob Morrison, Serdar Turkarslan, James E. Galagan, Tige R. Rustad, Mark J. Hickey, William Brabant, Kyle J. Minch
Publikováno v:
Nature Communications
Mycobacterium tuberculosis (MTB) infects 30% of all humans and kills someone every 20–30 s. Here we report genome-wide binding for ~80% of all predicted MTB transcription factors (TFs), and assayed global expression following induction of each TF.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d20fbbab3de269120972dadb9859d4
https://doi.org/10.1038/ncomms6829
https://doi.org/10.1038/ncomms6829
Autor:
William M. Atkins, Ranjana Mehta, David R. Sherman, Sumit Mahajan, Abhinav Nath, Josh T. Pearson, Mark J. Hickey
Publikováno v:
Journal of Biological Chemistry. 279:22477-22482
Bacterial glutamine synthetases (GSs) are complex dodecameric oligomers that play a critical role in nitrogen metabolism, converting ammonia and glutamate to glutamine. Recently published reports suggest that GS from Mycobacterium tuberculosis (MTb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad0d7d4c36388ef2c38e897da52e954
https://doi.org/10.1074/jbc.m401652200
https://doi.org/10.1074/jbc.m401652200
Autor:
David R. Sherman, Kristi M. Guinn, Jeff E. Grotzke, Mark J. Hickey, Kelly L. Zakel, David M. Lewinsohn, Sherilyn Smith, Sanjeev K. Mathur
Publikováno v:
Molecular Microbiology. 51:359-370
The RD1 genomic region is present in virulent strains of Mycobacterium tuberculosis (MTB), missing from the vaccine strain M. bovis BCG, and its importance to virulence has been established experimentally. Based on in silico analysis, it has been sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::231496d99f142df05be5192f3d92a0f7
https://doi.org/10.1046/j.1365-2958.2003.03844.x
https://doi.org/10.1046/j.1365-2958.2003.03844.x
Autor:
Tige R. Rustad, Mark J. Hickey, David R. Sherman, Nitin S. Baliga, William Brabant, Kyle J. Minch, Nathan D. Price, Shuyi Ma, Serdar Turkarslan, Samuel J. Hobbs, Jessica K. Winkler
Publikováno v:
Genome Biology
Background Mycobacterium tuberculosis senses and responds to the shifting and hostile landscape of the host. To characterize the underlying intertwined gene regulatory network governed by approximately 200 transcription factors of M. tuberculosis, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cf9dac049178ffe2ddb1118e9484aa
https://doi.org/10.1186/s13059-014-0502-3
https://doi.org/10.1186/s13059-014-0502-3
Autor:
David R. Sherman, L Embuscado, T.E McKennon, Mike Langhorne, T Kline, E Naeemi, S. K. Tanaka, L. Goltry, S Cai, Lynn Barker, Ribhi Shawar, M Fromhold, A Bigelow, N Ihle, L. L. Brody, S.U Anderson, Mark J. Hickey, Lisa Nguyen, Paul Warrener, J Treiberg, P.R Witte, William R. Schwan
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:73-93
As a strategy to increase the penetration of antibiotic drugs through the outer membrane of gram-negative pathogens, facilitated transport through siderophore receptors has been frequently exploited. Hydroxamic acids, catechols, or very close isoster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff5ff852cfb8a7d135084154be05eb4
https://doi.org/10.1016/s0968-0896(99)00261-8
https://doi.org/10.1016/s0968-0896(99)00261-8
Autor:
Sanjeev K. Mathur, Kelly L. Zakel, Mark J. Hickey, David R. Sherman, Kristi M. Guinn, Sherilyn Smith
Publikováno v:
The Journal of infectious diseases. 190(1)
Region of difference (RD1) genes are present in virulent Mycobacterium tuberculosis but not the vaccine strain M. bovis bacille Calmette-Guerin (BCG). The deletion of RD1 from M. tuberculosis produces an attenuation strikingly like that of BCG, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c616ad6b90b34dfa66bf30dc1370aff
https://pubmed.ncbi.nlm.nih.gov/15195251
https://pubmed.ncbi.nlm.nih.gov/15195251
Autor:
Kaeryn N. Lewis, Mark J. Hickey, David R. Sherman, Marcel A. Behr, Sherilyn Smith, Kristi M. Guinn, Reiling Liao
Publikováno v:
The Journal of infectious diseases. 187(1)
The tuberculosis (TB) vaccine bacille Calmette-Guerin (BCG) is a live attenuated organism, but the mutation responsible for its attenuation has never been defined. Recent genetic studies identified a single DNA region of difference, RD1, which is abs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4732a6fe3938a0f3d037ea7ecbefdf2e
https://pubmed.ncbi.nlm.nih.gov/12508154
https://pubmed.ncbi.nlm.nih.gov/12508154