Výsledky vyhledávání - "Mark J. Geels"

Roadmap for the establishment of a European vaccine R&D infrastructure

Autor: Stefan Jungbluth, Nathalie Imbault, Mark J. Geels, Joanna Korejwo, Odile Leroy, Betty Dodet

Publikováno v: Vaccine. 32(51):7021-7024

To consolidate the integration of the fragmented European vaccine development landscape, TRANSVAC – the European Network of Vaccine Research and Development, funded by the European Commission (EC) – has initiated the development of a roadmap thro

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TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: ‘How can big data help?’

Autor: Stefan H. E. Kaufmann, Jelle Thole, Carlos A. Guzmán, Helen A. Fletcher, Hans-Joachim Mollenkopf, Odile Leroy, Tom H. M. Ottenhoff, Mark J. Geels, Céline Dutruel

Publikováno v: Vaccine, 32(35), 4365-4368

High-throughput analyses of RNA and protein expression are increasingly used for better understanding of vaccine-induced immunity and protection against infectious disease. With an increasing number of vaccine candidates in clinical development, it i

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Development and qualification of the parallel line model for the estimation of human influenza haemagglutinin content using the single radial immunodiffusion assay

Autor: Harrie L. Glansbeek, J.F. van den Bosch, L. J. Buijs, G. van Kessel, S. de Weerd, J.G.M. Heldens, Mark J. Geels, M. A. M. de Bruijni, E. R. van den Heuvel

Publikováno v: Vaccine, 30, 201-209. Elsevier BV
van kessel, G, Geels, M J, de Weerd, S, Buijs, L J, de Bruijni, M A M, Glansbeek, H L, van den Bosch, J F, Heldens, J G & van den Heuvel, E R 2012, ' Development and qualification of the parallel line model for the estimation of human influenza haemagglutinin content using the single radial immunodiffusion assay. ', Vaccine, vol. 30, pp. 201-209 . https://doi.org/10.1016/j.vaccine.2011.11.023
Vaccine, 30(2), 201-209. ELSEVIER SCI LTD

Infection with human influenza virus leads to serious respiratory disease. Vaccination is the most common and effective prophylactic measure to prevent influenza. Influenza vaccine manufacturing and release is controlled by the correct determination

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https://hdl.handle.net/11370/26fb735f-135b-4456-a4a3-f4cc37ee3ee2

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Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation

Autor: Kiersten Anderson, Margreet Bakker, Georgios Pollakis, John W. Shiver, Sheri Dubey, William A. Paxton, Mark J. Geels, Elly Baan, Jaap Goudsmit

Publikováno v: Journal of virology, 79(17), 11247-11258. American Society for Microbiology

We aimed to identify cross-clade human immunodeficiency virus type 1 (HIV-1) specific T-cell responses among 10 HLA-typed individuals who were infected with non-B HIV-1 strains (A, AG, C, D, G, or F) and to correlate these responses with genetic vari

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https://doi.org/10.1128/jvi.79.17.11247-11258.2005

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Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual

Autor: J. Dekker, Jaap Goudsmit, Fokla Zorgdrager, Sheri Dubey, John W. Shiver, Tong-Ming Fu, David Kwa, Elly Baan, William A. Paxton, Martijn van Beelen, Lia van der Hoek, Marion Cornelissen, Kiersten Anderson, Jolanda Maas, Vladimir V. Lukashov, Hanneke Schuitemaker, Remco van den Burg, Mark J. Geels

Publikováno v: Journal of virology, 77(23), 12430-12440. American Society for Microbiology

Control of viremia in natural human immunodeficiency virus type 1 (HIV-1) infection in humans is associated with a virus-specific T-cell response. However, still much is unknown with regard to the extent of CD8+cytotoxic T-lymphocyte (CTL) responses

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https://doi.org/10.1128/jvi.77.23.12430-12440.2003

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TRANSVAC research infrastructure - Results and lessons learned from the European network of vaccine research and development

Autor: Carlos A. Guzmán, Samuel J. McConkey, Regitze L. Thogersen, Mei Mei Ho, James S. Robertson, Stefan H. E. Kaufmann, Mark J. Geels, Frank A. W. Verreck, Nicolas Collin, Odile Leroy

Publikováno v: Vaccine. 33(41)

TRANSVAC was a collaborative infrastructure project aimed at enhancing European translational vaccine research and training. The objective of this four year project (2009-2013), funded under the European Commission's (EC) seventh framework programme

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https://pubmed.ncbi.nlm.nih.gov/25667962

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European Vaccine Initiative: lessons from developing malaria vaccines

Autor: Mark J. Geels, Harry van Schooten, Marita Troye-Blomberg, Odile Leroy, Roland Dobbelaer, Egeruan B. Imoukhuede, Terry McWade, Alister Craig, Nathalie Imbault

For over 10 years, the European Vaccine Initiative (EVI; European Malaria Vaccine Initiative until 2009) has contributed to the development of 24 malaria candidate vaccine antigens with 13 vaccine candidates being advanced into Phase I clinical trial

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https://archive.lstmed.ac.uk/2457/1/erv.11.pdf

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Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte subpopulations upon ART initiation

Autor: Edwin J. Heeregrave, Georgios Pollakis, Renée M. van der Sluis, Elly Baan, William A. Paxton, Mark J. Geels

Publikováno v: AIDS research and therapy, 7(1). BioMed Central
AIDS Research and Therapy
AIDS Research and Therapy, Vol 7, Iss 1, p 42 (2010)

Background Although antiretroviral therapy (ART) has proven its success against HIV-1, the long lifespan of infected cells and viral latency prevent eradication. In this study we analyzed the sensitivity to ART of HIV-1 strains in naïve, central mem

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https://doi.org/10.1186/1742-6405-7-42

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Lack of in vivo compartmentalization among HIV-1 infected naïve and memory CD4+ T cell subsets

Autor: Rune Bennemeer, Edwin J. Heeregrave, William A. Paxton, Georgios Pollakis, Daniel C. Douek, Richard A. Koup, Elly Baan, Renée M. van der Sluis, David R. Ambrozak, Jaap Goudsmit, Mark J. Geels, Jason M. Brenchley

Publikováno v: Virology, 393(1), 24-32. Academic Press Inc.

Viral compartmentalization between naive and memory CD4(+) T cell subsets has been described, but only for individuals who were receiving antiretroviral therapy (ART). We present here an extensive analysis of the viral quasispecies residing in the na

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https://europepmc.org/articles/PMC2753733/

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