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Autor:
Mark J. Friesen, Christopher J. Patten, Teresa J. Smith, Sharon E. Murphy, C. S. Yang, Ronald E. Tynes
Publikováno v:
Carcinogenesis. 18(8)
The tobacco specific carcinogen N'-nitrosonornicotine (NNN), is believed to be a causative agent for esophageal cancer in smokers. NNN requires metabolic activation to exert its carcinogenic potential. Metabolism occurs through cytochrome P450 (P450)