Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Mark J. Dickman"'
Autor:
Emma N. Welbourne, Kate A. Loveday, Adithya Nair, Ehsan Nourafkan, Jixin Qu, Ken Cook, Zoltán Kis, Mark J. Dickman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
mRNA technology has recently demonstrated the ability to significantly change the timeline for developing and delivering a new vaccine from years to months. The potential of mRNA technology for rapid vaccine development has recently been highlighted
Externí odkaz:
https://doaj.org/article/73ff0f55f0334fa1b7cd0b5e2892d4de
Autor:
Simeon R. Mihaylov, Lydia M. Castelli, Ya-Hui Lin, Aytac Gül, Nikita Soni, Christopher Hastings, Helen R. Flynn, Oana Păun, Mark J. Dickman, Ambrosius P. Snijders, Robert Goldstone, Oliver Bandmann, Tatyana A. Shelkovnikova, Heather Mortiboys, Sila K. Ultanir, Guillaume M. Hautbergue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis, linking external stimuli to transcriptional co-activation of genes involved in adaptive and age-related pathways. The carboxyl-terminus encodes a se
Externí odkaz:
https://doaj.org/article/d4c65c08085643d58fc9598614996598
Autor:
George W. Mobbs, Adli A. Aziz, Samuel R. Dix, G. M. Blackburn, Sveta E. Sedelnikova, Thomas C. Minshull, Mark J. Dickman, Patrick J. Baker, Sheila Nathan, Mohd Firdaus Raih, David W. Rice
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
The crystal structure of the toxin from the pathogenic bacterium Burkholderia pseudomallei in complex with its target, human eIF4A, provides insights into substrate specificity and may facilitate the design of inhibitors for the treatment of melioido
Externí odkaz:
https://doaj.org/article/e58c27ff57b144fda8009caa288cd49d
Autor:
Vendula Krynická, Petra Skotnicová, Philip J. Jackson, Samuel Barnett, Jianfeng Yu, Anna Wysocka, Radek Kaňa, Mark J. Dickman, Peter J. Nixon, C. Neil Hunter, Josef Komenda
Publikováno v:
Plant Communications, Vol 4, Iss 1, Pp 100502- (2023)
FtsH proteases are membrane-embedded proteolytic complexes important for protein quality control and regulation of various physiological processes in bacteria, mitochondria, and chloroplasts. Like most cyanobacteria, the model species Synechocystis s
Externí odkaz:
https://doaj.org/article/8669f25bb61e4e8ba89e44601ad01fcf
Autor:
James Hough, John D. Howard, Stephen Brown, David E. Portwood, Peter M. Kilby, Mark J. Dickman
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Current crop pest control strategies rely on insecticidal and fungicidal sprays, plant genetic resistance, transgenes and agricultural practices. However, many insects, plant viruses, and fungi have no current means of control or have developed resis
Externí odkaz:
https://doaj.org/article/a3eccdba05404b3b839e2cace1a41570
Autor:
Victor S. Njom, Tim Winks, Oumu Diallo, Ann Lowe, Jerzy Behnke, Mark J. Dickman, Ian Duce, Iain Johnstone, David J. Buttle
Publikováno v:
Parasites & Vectors, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Background Plant-derived cysteine proteinases of the papain family (CPs) attack nematodes by digesting the cuticle, leading to rupture and death of the worm. The nematode cuticle is composed of collagens and cuticlins, but the specific molec
Externí odkaz:
https://doaj.org/article/1b361152734241d987af742259d09dbe
Autor:
Sarah E. Flannery, Federica Pastorelli, William H. J. Wood, C. Neil Hunter, Mark J. Dickman, Philip J. Jackson, Matthew P. Johnson
Publikováno v:
Plant Direct, Vol 5, Iss 10, Pp n/a-n/a (2021)
Abstract Compared to controlled laboratory conditions, plant growth in the field is rarely optimal since it is frequently challenged by large fluctuations in light and temperature which lower the efficiency of photosynthesis and lead to photo‐oxida
Externí odkaz:
https://doaj.org/article/a368511e3a6a4fe1879a34265a036de2
Autor:
Joby Cole, Adrienn Angyal, Richard D. Emes, Tim John Mitchell, Mark J. Dickman, David H. Dockrell
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Epigenetic modifications regulate gene expression in the host response to a diverse range of pathogens. The extent and consequences of epigenetic modification during macrophage responses to Streptococcus pneumoniae, and the role of pneumolysin, a key
Externí odkaz:
https://doaj.org/article/fbd48eadf6794e8ca4498eb2aac07aff
Autor:
Chunyan Liao, Ryan Beveridge, Jessica J.R. Hudson, Jacob D. Parker, Shih-Chieh Chiang, Swagat Ray, Mohamed E. Ashour, Ian Sudbery, Mark J. Dickman, Sherif F. El-Khamisy
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3352-3365 (2018)
Summary: Genomic damage can feature DNA-protein crosslinks whereby their acute accumulation is utilized to treat cancer and progressive accumulation causes neurodegeneration. This is typified by tyrosyl DNA phosphodiesterase 1 (TDP1), which repairs t
Externí odkaz:
https://doaj.org/article/ba5874b13fb94344979914ea868f0b6c
Autor:
Christina J. Vanhinsbergh, Angela Criscuolo, Jennifer N. Sutton, Keeley Murphy, Andrew J. K. Williamson, Ken Cook, Mark J. Dickman
Publikováno v:
Analytical Chemistry. 94:7339-7349
Large RNA including mRNA (mRNA) has emerged as an important new class of therapeutics. Recently, this has been demonstrated by two highly efficacious vaccines based on mRNA sequences encoding for a modified version of the SARS-CoV-2 spike protein. Th