Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Mark J. Coster"'
Autor:
Megan Cross, Siji Rajan, Janine Chekaiban, Jake Saunders, Chloe Hamilton, Jeong-Sun Kim, Mark J. Coster, Robin B. Gasser, Andreas Hofmann
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Owing to the key role of trehalose in pathogenic organisms, there has recently been growing interest in trehalose metabolism for therapeutic purposes. Trehalose-6-phosphate phosphatase (TPP) is a pivotal enzyme in the most prominent biosynth
Externí odkaz:
https://doaj.org/article/d836d5dfbaf740808ada4988984968f9
Autor:
Daniel J. G. Johnson, Ian D. Jenkins, Cohan Huxley, Mark J. Coster, Kah Yean Lum, Jonathan M. White, Vicky M. Avery, Rohan A. Davis
Publikováno v:
Molecules, Vol 26, Iss 9, p 2421 (2021)
A radical approach to late-stage functionalization using photoredox and Diversinate™ chemistry on the Open Source Malaria (OSM) triazolopyrazine scaffold (Series 4) resulted in the synthesis of 12 new analogues, which were characterized by NMR, UV,
Externí odkaz:
https://doaj.org/article/6f3deda7a0494610ab87f1141ddbc384
Autor:
Brett D. Schwartz, Mark J. Coster, Tina S. Skinner-Adams, Katherine T. Andrews, Jonathan M. White, Rohan A. Davis
Publikováno v:
Marine Drugs, Vol 13, Iss 9, Pp 5784-5795 (2015)
Six regioisomers associated with the tricyclic core of thiaplakortones A–D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequentl
Externí odkaz:
https://doaj.org/article/623c45ec2ba348dcb643745991d2732a
Publikováno v:
Molecules, Vol 24, Iss 21, p 3938 (2019)
The reaction of papaverine with a series of Baran DiversinatesTM is reported. Although the yields were low, it was possible to synthesize a small biodiscovery library using this plant alkaloid as a scaffold for late-stage C−H functionalization. Ten
Externí odkaz:
https://doaj.org/article/2e5345c6703f47fd8f6bda7c3aaaf6a4
Publikováno v:
Journal of Chemical Education. 96:1033-1036
Success in undergraduate chemical experiments requires students to develop knowledge and skills of instrumentation, equipment, and chemical techniques. In this technology report, we propose an adap...
Autor:
Siji Rajan, Sonja Biberacher, Robin B. Gasser, Andreas Hofmann, Suk-Youl Park, Megan Cross, Mark J. Coster, Jeong-Sun Kim, Pasi K. Korhonen
Publikováno v:
The FASEB Journal. 32:5470-5482
The opportunistic bacterium Pseudomonas aeruginosa has been recognized as an important pathogen of clinical relevance and is a leading cause of hospital-acquired infections. The presence of a glycolytic enzyme in Pseudomonas, which is known to be inh
Autor:
Mark J. Coster, Romain J. Lepage
Publikováno v:
Tetrahedron. 74:1313-1321
The stereoselective synthesis of 5,5-spiroacetals by Rh(II)-catalysed double C–H insertion of methylene acetals bearing two diazo ester substituents is described. The diastereoselectivity of this bidirectional approach can be tuned through appropri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3185-3189
The plant natural product, valerenic acid (1) was chosen as a desirable scaffold for the generation of a novel screening library due to its drug-like physicochemical parameters (such as LogP, hydrogen bond donor/acceptor counts, and molecular weight)
Autor:
Zara C. Bruce, Rochelle C.J. D’Souza, Baek Kim, Yi Chieh Lim, Kum Kum Khanna, Andrew W. Boyd, Mark J. Coster, Jason K. Cullen, Petra Hamerlik, Valentina Cianfanelli, Lisa Maria Wiesmueller, Adrian P. Wiegmans, Kathleen S. Ensbey, Brett W. Stringer, Amanda W. Kijas, Rosalind L. Jeffree, Fanny J. Lombard, Fiona M. Smith, Tara L. Roberts, Bijan Mahboubi, Carolin Offenhäuser, Martin F. Lavin, Bryan W. Day, Hazel Quek, Terrance Grant Johns, Amanda L. Bain
Publikováno v:
Neuro Oncol
Neuro-Oncology
Neuro-Oncology
Background Despite significant endeavor having been applied to identify effective therapies to treat glioblastoma (GBM), survival outcomes remain intractable. The greatest nonsurgical benefit arises from radiotherapy, though tumors typically recur du
Publikováno v:
Journal of computational biology : a journal of computational molecular cell biology. 26(12)
Dipeptidyl peptidase-4 (DPP-4) is considered a major drug target for type 2 diabetes mellitus (T2DM). In addition to T2DM, a regulatory role of DPP-4 was also found in cardiovascular diseases. Existing DPP-4 inhibitors have been reported to have seve