Výsledky vyhledávání - "Mark J. Coleman"

Process Research and Development of a Dihydropyrimidine Dehydrogenase Inactivator: Large-Scale Preparation of Eniluracil Using a Sonogashira Coupling

Autor: Robert Bright, Kevin P. Jenkins, Jason W. B. Cooke, and Mark J. Coleman

Publikováno v: Organic Process Research & Development. 5:383-386

Eniluracil (5-ethynyluracil) is a potent inactivator of the enzyme dihydropyrimidine dehydrogenase, which is the rate-limiting enzyme in the metabolism of 5-fluorouracil, a widely used anti-cancer drug. The process research and development of a three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59e9f000bb19ad504fcb39967413cf01
https://doi.org/10.1021/op0100100

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Baeyer−Villiger Oxidation of 5-endo-(Biphenyl-4-ylmethoxy)-7-anti-piperidinobicyclo[2.2.1]heptan-2-one: Process Development and Scale-Up

Autor: Derek L. Crookes, Christopher J. Wallis, Mark J. Coleman, and David R. Marshall, Malcolm L. Hill, Hardev Singh

Publikováno v: Organic Process Research & Development. 1:20-25

The Baeyer−Villiger oxidation of 7-anti-piperidino, 5-endo-biphenyl-4-ylmethoxy substituted norbornan-2-one was developed to provide a robust, reproducible process for manufacture of the regioisomeric lactone which results from migration of the bri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d4cad306c53d0e5c963cbf792f490b5
https://doi.org/10.1021/op9600062

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ChemInform Abstract: Efficient Synthesis of 2-Trihalomethyl-5-cyanopyridines

Autor: Mark J. Coleman, Kevin P Jenkins, Darren M. Caine, Jason W. B. Cooke

Publikováno v: ChemInform. 30

Efficient and practicable routes to 2-trifluoromethyl-5-cyanopyridine, 2-bromodifluoromethyl-5-cyanopyridine and 2-chlorodifluoromethyl-5-cyanopyridine have been developed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8eff77f6de781d00d25832afeb98558
https://doi.org/10.1002/chin.199901149

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ChemInform Abstract: A Convenient Method for the N-Acylation and Esterification of Hindered Amino Acids: Synthesis of Ultra Short Acting Opioid Agonist, Remifentanil

Autor: Michael David Goodyear, Whitehead Andrew Jonathan, Latham William David Stuart, Mark J. Coleman

Publikováno v: ChemInform. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17ddbb2e8b129f8bbf77c7cb75fa8207
https://doi.org/10.1002/chin.200012095

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The use of TnphoAinErwinia amylovorato generate random fusions of alkaline phosphatase to extracytoplasmic proteins

Autor: I S Roberts, Jonathan Milner, Richard M. Cooper, Mark J. Coleman

Publikováno v: FEMS Microbiology Letters. 80:167-172

Tn phoA has been introduced with high efficiency into the chromosome of the phytopathogenic bacterium Erwinia amylovora. Transposition occurred with apparent randomness and single insertions were predominant. Fusion proteins were detected in cell env

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19df491b1d3adf3acb05eec2ae39e2c4
https://doi.org/10.1111/j.1574-6968.1991.tb04655.x

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A Convenient Method for the N-Acylation and Esterification of Hindered Amino Acids: Synthesis of Ultra Short Acting Opioid Agonist, Remifentanil

Autor: Latham William David Stuart, Whitehead Andrew Jonathan, Mark J. Coleman, Michael David Goodyear

Publikováno v: Synlett. 1999:1923-1924

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b27096d30f382236f64edd8975df04b
https://doi.org/10.1055/s-1999-2978

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Molecular cloning, expression and nucleotide sequence of the rcsA gene of Erwinia amylovora, encoding a positive regulator of capsule expression: evidence for a family of related capsule activator proteins

Autor: Ian Roberts, John W. Mansfield, Francis Busfield, Rowan Pearce, Ed Hitchin, Mark J. Coleman

Publikováno v: Journal of general microbiology. 136(9)

Summary: A gene encoding a positive activator of the expression of extracellular polysaccharide (EPS) synthesis in the phytopathogen Erwinia amylovora has been isolated from a genomic library in Escherichia coli. The presence of the cloned gene in E.

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https://pubmed.ncbi.nlm.nih.gov/2283503

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Efficient synthesis of 2-trihalomethyl-5-cyanopyridines

Autor: Kevin P Jenkins, Darren M. Caine, Jason W. B. Cooke, Mark J. Coleman

Publikováno v: Tetrahedron Letters. 39:7965-7966

Efficient and practicable routes to 2-trifluoromethyl-5-cyanopyridine, 2-bromodifluoromethyl-5-cyanopyridine and 2-chlorodifluoromethyl-5-cyanopyridine have been developed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa7f2aa6b87286274577e73a943546a3
https://doi.org/10.1016/s0040-4039(98)01731-6

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