Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mark J. Canet"'
Publikováno v:
Molecular Metabolism, Vol 4, Iss 12, Pp 951-960 (2015)
Objective: Metabolic inflammation is believed to promote insulin resistance and type 2 diabetes progression in obesity. TRAF3, a cytoplasmic signaling protein, has been known to mediate/modulate cytokine signaling in immune cells. The goal is to defi
Externí odkaz:
https://doaj.org/article/f1c42fb7357c4d1c977503bd370bca10
Autor:
Robert A. Craig, Brian M. Fox, Cheng Hu, Katrina W. Lexa, Maksim Osipov, Arun P. Thottumkara, Martin Larhammar, Takashi Miyamoto, Anil Rana, Lesley A. Kane, Ernie Yulyaningsih, Hilda Solanoy, Hoang Nguyen, Roni Chau, Timothy Earr, Yuji Kajiwara, Daniel Fleck, Anthony Lucas, Patrick C. G. Haddick, Ryan H. Takahashi, Vincent Tong, Jing Wang, Mark J. Canet, Suresh B. Poda, Kimberly Scearce-Levie, Ankita Srivastava, Zachary K. Sweeney, Musheng Xu, Rui Zhang, Jianrong He, Yanan Lei, Zheng Zhuo, Javier de Vicente
Publikováno v:
Journal of Medicinal Chemistry. 65:16290-16312
Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a considerable interest in developing DLK/LZK inhibitors for neurodegenerative diseases. Herein, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba59c66263d4a021ad8e4342b49383cd
https://doi.org/10.1021/acs.jmedchem.2c01056
https://doi.org/10.1021/acs.jmedchem.2c01056
Autor:
Yi Xiong, Adriana Souza Torsoni, Feihua Wu, Hong Shen, Yan Liu, Xiao Zhong, Mark J Canet, Yatrik M Shah, M Bishr Omary, Yong Liu, Liangyou Rui
Publikováno v:
eLife, Vol 7 (2018)
Reparative hepatocyte replication is impaired in chronic liver disease, contributing to disease progression; however, the underlying mechanism remains elusive. Here, we identify Map3k14 (also known as NIK) and its substrate Chuk (also called IKKα) a
Externí odkaz:
https://doaj.org/article/d7fccf95dcf740dfbdf8b26aeb5531e3
Autor:
Xiao Zhong, Yi Xiong, Adriana Souza Torsoni, Yong Liu, Yatrik M. Shah, Liangyou Rui, Yan Liu, Mark J. Canet, Hong Shen, M. Bishr Omary, Feihua Wu
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Reparative hepatocyte replication is impaired in chronic liver disease, contributing to disease progression; however, the underlying mechanism remains elusive. Here, we identify Map3k14 (also known as NIK) and its substrate Chuk (also called IKKα) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22617628b406786b5eb9314c512e727
https://elifesciences.org/articles/34152
https://elifesciences.org/articles/34152
Autor:
Xiao Zhong, Yan Liu, Adriana Souza Torsoni, Yatrik M. Shah, Liangyou Rui, Yi Xiong, Yong Liu, Mark J. Canet, Hong Shen, M. Bishr Omary, Feihua Wu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cce7cab6861a2097dd878ab40b7a530
https://doi.org/10.7554/elife.34152.028
https://doi.org/10.7554/elife.34152.028
Autor:
Adriana Souza Torsoni, Liangyou Rui, Yan Liu, Yi Xiong, Hong Shen, Bishr M Omary, Yong Liu, Mark J. Canet, Yatrik M. Shah, Feihua Wu
SummaryHepatocyte replication maintains liver homeostasis and integrity. It is impaired in chronic liver disease, promoting disease progression. Herein, we have identified NF-kB-inducing kinase (NIK) as an unrecognized suppressor of hepatocyte replic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b805b1c7584bdd22372579ce85c36536
https://doi.org/10.1101/238717
https://doi.org/10.1101/238717
Autor:
Nathan J. Cherrington, Robert P. Erickson, Stavra A. Xanthakos, Joel E. Lavine, John D. Clarke, Mark J. Canet, Dean Billheimer, Hui Li
Variable drug responses depend on individual variation in the activity of drug-metabolizing enzymes, including cytochrome P450 enzymes (CYP). As the most common chronic liver disease in children and adults, nonalcoholic steatohepatitis (NASH) has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a5b6418bf3f5cf2ca99a41b302c9c8
https://europepmc.org/articles/PMC5697442/
https://europepmc.org/articles/PMC5697442/
Autor:
Stavra A. Xanthakos, Robert P. Erickson, Rhiannon N. Hardwick, Hassan H. A-Kader, Mark J. Canet, Nathan J. Cherrington, Amy M. Bataille, José E. Manautou, Daniel W. Ferreira, Sarah N. Campion, Matthew D. Merrell
Publikováno v:
Drug Metabolism and Disposition. 43:829-835
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, representing a spectrum of liver pathologies that include simple hepatic steatosis and the more advanced nonalcoholic steatohepatitis (NASH). The current study was con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1cfa7b4b20d2563371cecd87810bc9
https://doi.org/10.1124/dmd.114.062703
https://doi.org/10.1124/dmd.114.062703
Autor:
Jonathan P. Jackson, Nathan J. Cherrington, Tongde Wu, Mark J. Canet, Bryan Harder, Jonathan M. Maher, Matthew D. Merrell, Andrew J. Lickteig, Donna D. Zhang, Masayuki Yamamoto
Publikováno v:
Drug Metabolism and Disposition. 43:93-99
The ATP-binding cassette (ABC) family of transporters, including ABCC3, is a large family of efflux pumps that plays a pivotal role in the elimination of xenobiotics from the body. ABCC3 has been reported to be induced during hepatic stress condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615ad5b293cb09f437b74fe2de4984bc
https://doi.org/10.1124/dmd.114.060103
https://doi.org/10.1124/dmd.114.060103
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:452-458
Simvastatin (SIM)-induced myopathy is a dose-dependent adverse drug reaction (ADR) that has been reported to occur in 18.2% of patients receiving a 40- to 80-mg dose. The pharmacokinetics of SIM hydroxy acid (SIMA), the bioactive form of SIM, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de960008959ae49c2632ed6131de4f6
https://doi.org/10.1124/jpet.113.211284
https://doi.org/10.1124/jpet.113.211284