Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mark J. Bartlett"'
Publikováno v:
Public Health Research & Practice, Vol 31, Iss 5 (2021)
Objectives: We sought to determine the ease with which breast cancer pathology data could be ascertained for a large cohort of Australian women, to support epidemiological research. Method: We assessed a range of options for accessing breast cance
Externí odkaz:
https://doaj.org/article/df828702364e45f99a5cb6fa2341b030
Publikováno v:
ACS Catalysis. 7:2548-2552
We report the development of a modular, one-pot, sequential chemoenzymatic system for the formal enantioselective construction of the C–C bond in 2-aryl 1,4-dicarbonyl compounds. This sequence comprises a rhodium-catalyzed diazocoupling that provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfc15a21212b9a189b167b8556642c68
https://doi.org/10.1021/acscatal.7b00254
https://doi.org/10.1021/acscatal.7b00254
Publikováno v:
ACS Catalysis. 5:3817-3822
We report the development of a tandem chemoenzymatic transformation that combines alkene metathesis with enzymatic epoxidation to provide aryl epoxides. The development of this one-pot reaction required substantial protein and reaction engineering to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::986a70c976e0c9217ac82261932efd68
https://doi.org/10.1021/acscatal.5b00533
https://doi.org/10.1021/acscatal.5b00533
Autor:
Barry M. Trost, Mark J. Bartlett
Publikováno v:
Accounts of Chemical Research
Conspectus The development of catalytic enantioselective transformations has been the focus of many research groups over the past half century and is of paramount importance to the pharmaceutical and agrochemical industries. Since the award of the No
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c588dacf8151953dc0c08d583d3286e
https://doi.org/10.1021/ar500374r
https://doi.org/10.1021/ar500374r
Publikováno v:
The Journal of Organic Chemistry. 79:5521-5532
The rational analysis of (13)C NMR axial shielding effects has enabled the assignment of remote relative stereochemistry in 3,6-oxygen-substituted 3,6-dihydro-2H-pyrans. Comparison of the (13)C NMR shifts of equivalent centers in cis- and trans-subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e0cd41ec8fd0bf0de4d894f88379f0
https://doi.org/10.1021/jo500678k
https://doi.org/10.1021/jo500678k
Publikováno v:
Angewandte Chemie International Edition. 53:465-469
Although chemical and enzymatic catalysts have been combined, reactions in which an organometallic catalyst and a metalloenzyme work cooperatively to create products, which cannot be generated with either catalyst alone or in comparable yields by seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f6d38afa1d405b635b66aca61c1bbf
https://doi.org/10.1002/anie.201305778
https://doi.org/10.1002/anie.201305778
Publikováno v:
Organic Letters. 15:2430-2433
A regioselective palladium-catalyzed allylic alkylation cascade forms furo[3,2-c]pyrans from various cyclic β-dicarbonyl bis-nucleophiles and 3,6-dihydro-2H-pyran bis-electrophiles. The combination of allylic carbonate and anomeric siloxy leaving gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5398c510048a9a9225ff45dceb6a0d
https://doi.org/10.1021/ol400902d
https://doi.org/10.1021/ol400902d
Publikováno v:
Chemistry - A European Journal. 18:16498-16509
The development of a general and practical zinc-catalyzed enantioselective alkyne addition methodology is reported. The commercially available ProPhenol ligand (1) has facilitated the addition of a wide range of zinc alkynylides to aryl, aliphatic, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4822e1efe94805cf0e2e235090c29213
https://doi.org/10.1002/chem.201202085
https://doi.org/10.1002/chem.201202085
Autor:
Mark J. Bartlett, Barry M. Trost
Publikováno v:
Organic Letters. 14:1322-1325
A catalytic enantioselective formal total synthesis of aspergillide B is reported. This linchpin synthesis was enabled by the development of new conditions for Zn-ProPhenol catalyzed asymmetric alkyne addition. This reaction was used in conjunction w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e67f7ab63ec3eb25bf6c7289b285663
https://doi.org/10.1021/ol300200m
https://doi.org/10.1021/ol300200m
Publikováno v:
Drug Metabolism and Personalized Therapy. 31
The study of pharmacogenomics has, by harnessing sequence information from human genomes, the potential to lead to novel approaches in drug discovery, an individualized application of drug therapy, and new insights into disease prevention. For this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9364a346820a86c1d029fc15c6f700b9
https://doi.org/10.1515/dmpt-2015-0044
https://doi.org/10.1515/dmpt-2015-0044