Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mark J. Acerson"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3258-3262
Resveratrol (RV) 1 , a plant polyphenol, has proven effective in commercial products yet drawbacks include low bioavailability due to rapid metabolism. Structural modifications have led to a 4′-acetoxy analog 2 (4AR) now produced using a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c37c855a888dd61eed3c3dc7ed368dc
https://doi.org/10.1016/j.bmcl.2016.05.068
https://doi.org/10.1016/j.bmcl.2016.05.068
Publikováno v:
Tetrahedron Letters. 56:3277-3280
Terpene based mimics of the anti-cancer agent (−)-englerin A have been designed and produced from (+)- and (−)-bornyl acetate and (+)-fenchol. A key remote CH 2 oxidation reaction was developed using chromium(VI) oxide in acetic acid (115 °C) ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c6640edb40bab2b2749e75f78946f3a
https://doi.org/10.1016/j.tetlet.2015.02.071
https://doi.org/10.1016/j.tetlet.2015.02.071
Autor:
Merritt B. Andrus, Mark J. Acerson
Publikováno v:
Tetrahedron Letters. 55:757-760
Selective esterification of the polyphenol resveratrol was performed under thermodynamic conditions using NaH and acid anhydrides to directly access 4′-esters. Standard conditions with acetyl chloride and pyridine showed poor selectivity, favoring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f6a7b60a815bb2f934cde1481f8308d
https://doi.org/10.1016/j.tetlet.2013.12.019
https://doi.org/10.1016/j.tetlet.2013.12.019
Autor:
Crystal Blake, Edwin D. Lephart, Yong Wong, Kimberly M. Fabick, Mark J. Acerson, Merritt B. Andrus
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2941-2944
The 4′-ester analog of the disease preventative resveratrol 1 (RV), 4′-acetyl-RV 2 along with 4′-pivaloate 13 and benzoate 14 RV were synthesized. The previously developed palladium catalyzed decarbonylative Heck coupling was used to assemble t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21266282ed46ec57bd9011d4173d681
https://doi.org/10.1016/j.bmcl.2013.03.046
https://doi.org/10.1016/j.bmcl.2013.03.046
Publikováno v:
Journal of the American Chemical Society. 138(16)
The exchange of subunits between homodimeric mutant Cu, Zn superoxide dismutase (SOD1) and wild-type (WT) SOD1 is suspected to be a crucial step in the onset and progression of amyotrophic lateral sclerosis (ALS). The rate, mechanism, and ΔG of hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21af91891d0ae34f3f066cc54605e6e8
https://pubmed.ncbi.nlm.nih.gov/27054659
https://pubmed.ncbi.nlm.nih.gov/27054659
Publikováno v:
ACS chemical neuroscience. 6(10)
The monomerization of Cu, Zn superoxide dismutase (SOD1) is an early step along pathways of misfolding linked to amyotrophic lateral sclerosis (ALS). Monomerization requires the reversal of two post-translational modifications that are thermodynamica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d928d038a6903cd90b0bfb084abbed3
https://pubmed.ncbi.nlm.nih.gov/26207449
https://pubmed.ncbi.nlm.nih.gov/26207449