Preparation of 3‑Substituted Isoindolin-1-one, Cinnoline, and 1,2,4‑[e]‑Benzotriazine Derivatives

Autor: Fatat B. El Dhaibi, Ali Youssef, James C. Fettinger, Mark J. Kurth, Makhluf J. Haddadin

Publikováno v: ACS Omega, Vol 7, Iss 30, Pp 26871-26880 (2022)

Externí odkaz: https://doaj.org/article/5e4cdbcbc1464f149a74db966841fbc2

Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies

Autor: Aizhan Abdildinova, Mark J. Kurth, Young-Dae Gong

Publikováno v: Pharmaceuticals, Vol 14, Iss 5, p 449 (2021)

Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers

Externí odkaz: https://doaj.org/article/3b2c2340ee894d708bc218b0fd20490b

Data from Halogenated Benzimidazole Carboxamides Target Integrin α4β1 on T-Cell and B-Cell Lymphomas

Autor: Mark J. Kurth, Kit S. Lam, Sally J. DeNardo, Felice C. Lightstone, Danielle M. Solano, Mirela Andrei, Edmond Y. Lau, Arutselvan Natarajan, Richard D. Carpenter

Integrin α4β1 is an attractive but poorly understood target for selective diagnosis and treatment of T-cell and B-cell lymphomas. This report focuses on the rapid microwave preparation, structure-activity relationships, and biological evaluation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664072d35f8e6155e4f60d85bccb4ae2
https://doi.org/10.1158/0008-5472.c.6500661

Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma

Autor: Franck Letourneur, Jérémy Augustin, Mark J. Kurth, Julie Le Naour, Sylvie Lachkar, Pamela Caudana, Eliane Piaggio, Youra Kim, Sarah Levesque, Jie S. Zhu, Guido Kroemer, Jonathan Pol, Bouchra Lekbaby, Andrea Checcoli, Patrick S.C. Leung, Allan Sauvat, Shashi Gujar, Agathe Delaune, Chantal Housset, Pierre de la Grange, Paule Opolon, Laura Fouassier, Noémie Robil, Laurence Zitvogel, Patrick Soussan, Juliette Paillet, Céleste Plantureux, Jimena Tosello Boari, M. Eric Gershwin, Isabelle Martins, Maria Chiara Maiuri, Cédric Coulouarn, Gautier Stoll, Norma Bloy, Gwennhael Autret, Juliette Hamroune

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (10), pp.1-33. ⟨10.1084/jem.20200853⟩
Journal of Experimental Medicine, 2021, 218 (10), pp.1-33. ⟨10.1084/jem.20200853⟩
The Journal of experimental medicine, vol 218, iss 10

International audience; Cholangiocarcinoma (CCA) results from the malignant transformation of cholangiocytes. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are chronic diseases in which cholangiocytes are primarily damage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da6bf3a0955886ad743ba036eab6335
https://hal.archives-ouvertes.fr/hal-03378827

Synthesis and evaluation of tetrahydropyrazolopyridine inhibitors of anion exchange protein SLC26A4 (pendrin)

Autor: Mark J. Kurth, Peter M. Haggie, Marina E. Shatskikh, Julia Y. Lu, Jung-Ho Son, Alan S. Verkman, Amber A. Rivera, Joseph-Anthony Tan, Jie S. Zhu, Puay-Wah Phuan

Publikováno v: Bioorganic & medicinal chemistry letters, vol 29, iss 16
Bioorg Med Chem Lett

Pendrin is a transmembrane chloride/anion antiporter that is strongly upregulated in the airways in rhinoviral infection, asthma, cystic fibrosis and chronic rhinosinusitis. Based on its role in the regulation of airway surface liquid depth, pendrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5b365bb1f538164643be9aacb68beb
https://doi.org/10.1016/j.bmcl.2019.07.003