Výsledky vyhledávání - "Mark J de Lange"

Akademický článek

Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.

Autor: Mark J de Lange, Lubna Razzaq, Mieke Versluis, Sven Verlinde, Mehmet Dogrusöz, Stefan Böhringer, Marina Marinkovic, Gregorius P M Luyten, Rob J W de Keizer, Frank R de Gruijl, Martine J Jager, Pieter A van der Velden

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138002 (2015)

Uveal melanomas (UM) originate from melanocytes in the interior wall of the eye, namely from the iris, ciliary body and the choroid with marked differences in light exposure (from dark anterior to illuminated posterior). In contrast to UV radiation,

Externí odkaz: https://doaj.org/article/cde04f31e7364c04b9174b39f6f9d888

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Akademický článek

Digital PCR validates 8q dosage as prognostic tool in uveal melanoma.

Autor: Mieke Versluis, Mark J de Lange, Sake I van Pelt, Claudia A L Ruivenkamp, Wilma G M Kroes, Jinfeng Cao, Martine J Jager, Gre P M Luyten, Pieter A van der Velden

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0116371 (2015)

Uveal melanoma (UM) development and progression is correlated with specific molecular changes. Recurrent mutations in GNAQ and GNA11 initiate UM development while tumour progression is correlated with monosomy of chromosome 3 and gain of chromosome 8

Externí odkaz: https://doaj.org/article/6d302590983641da984258cff1c9598d

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Akademický článek

Scientific and clinical implications of genetic and cellular heterogeneity in uveal melanoma

Autor: Mark J. de Lange, Rogier J. Nell, Pieter A. van der Velden

Publikováno v: Molecular Biomedicine, Vol 2, Iss 1, Pp 1-10 (2021)

Abstract Here, we discuss the presence and roles of heterogeneity in the development of uveal melanoma. Both genetic and cellular heterogeneity are considered, as their presence became undeniable due to single cell approaches that have recently been

Externí odkaz: https://doaj.org/article/aee7e46399ef45ce9688686aefa60519

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Supplemental methods from Digital PCR-Based T-cell Quantification–Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma

Autor: Pieter A. van der Velden, Thorbald van Hall, Willem H. Zoutman, Sjoerd H. van der Burg, Martine J. Jager, Gre P.M. Luyten, Ekaterina S. Jordanova, Mieke Versluis, Rajshri N. Lalai, Rogier J. Nell, Mark J. de Lange

Description of analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e3319b496d281565bb538613a3316a
https://doi.org/10.1158/1541-7786.22515889.v1

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Table S2 from Digital PCR-Based T-cell Quantification–Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma

Tumor T-cell count

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f64deee999a19194258b5013a0c8d35
https://doi.org/10.1158/1541-7786.22515880.v1

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Data from Digital PCR-Based T-cell Quantification–Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma

Uveal melanoma progression can be predicted by gene expression profiles enabling a clear subdivision between tumors with a good (class I) and a poor (class II) prognosis. Poor prognosis uveal melanoma can be subdivided by expression of immune-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::baf455e2891e732d3a67e01ebb315c97
https://doi.org/10.1158/1541-7786.c.6541210

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Accurate Quantification of T Cells by Measuring Loss of Germline T-Cell Receptor Loci with Generic Single Duplex Droplet Digital PCR Assays

Autor: Pieter A. van der Velden, Maarten H. Vermeer, Mark J. de Lange, Anton W. Langerak, Mieke Versluis, Rogier J. Nell, Debby van Steenderen, Rajshri N. Lalai, Willem H. Zoutman, Jacoba J. Out-Luiting

Publikováno v: The Journal of Molecular Diagnostics, 19(2), 236-243
Journal of Molecular Diagnostics, 19(2), 236-243. Elsevier Inc.

Quantifying T cells accurately in a variety of tissues of benign, inflammatory, or malignant origin can be of great importance in a variety of clinical applications. Flow cytometry and immunohistochemistry are considered to be gold-standard methods f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9d987fcb9bf93c810fce63abb3395b
https://pure.eur.nl/en/publications/54e31535-3977-40ef-8c7c-0a325dcb211e

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Digital PCR-Based T-cell Quantification-Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma

Autor: Gre P. M. Luyten, Mark J. de Lange, Martine J. Jager, Mieke Versluis, Willem H. Zoutman, Pieter A. van der Velden, Thorbald van Hall, Rajshri N Lalai, Rogier J. Nell, Sjoerd H. van der Burg, Ekaterina S. Jordanova

Publikováno v: Molecular Cancer Research, 16(12), 1902-1911
de Lange, M J, Nell, R J, Lalai, R N, Versluis, M, Jordanova, E S, Luyten, G P M, Jager, M J, van der Burg, S H, Zoutman, W H, van Hall, T & van der Velden, P A 2018, ' Digital PCR-Based T-cell Quantification-Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma ', Molecular Cancer Research, vol. 16, no. 12, pp. 1902-1911 . https://doi.org/10.1158/1541-7786.MCR-18-0114
Molecular Cancer Research, 16(12), 1902-1911. American Association for Cancer Research Inc.
Molecular Cancer Research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2d494f9f32b9aa23369d2a4d589d6b
http://hdl.handle.net/1887/87126

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Targeting of the MAPK and AKT pathways in conjunctival melanoma shows potential synergy

Autor: Mehmet Dogrusöz, Mark J. de Lange, Jinfeng Cao, Aart G. Jochemsen, Martine J. Jager, Robert M. Verdijk, Renier Heijkants, Sjoerd H. van der Burg, Pieter A. van der Velden

Publikováno v: Virchows Archiv, 469, S11-S11
Oncotarget, 8(35), 58021-58036
Oncotarget, 8(35), 58021-58036. Impact Journals LLC
Oncotarget

// Jinfeng Cao 1, 2 , Renier C. Heijkants 3 , Aart G. Jochemsen 3 , Mehmet Dogrusoz 1 , Mark J. de Lange 1 , Pieter A. van der Velden 1 , Sjoerd H. van der Burg 5 , Martine J. Jager 1, * and Robert M. Verdijk 4, * 1 Department of Ophthalmology, Leide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a19f7bd09f1b740c364d24633d37afd
https://hdl.handle.net/1887/115154

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Loss of MAPK Pathway Activation in Post-Mitotic Retinal Cells as Mechanism in MEK Inhibition-Related Retinopathy in Cancer Patients

Autor: Ellen Kapiteijn, Elon H. C. van Dijk, Mark J. de Lange, Camiel J. F. Boon, Pieter A. van der Velden, Mieke Versluis, Danique E. M. Duits, Arthur A.B. Bergen, Gregrorius P. M. Luyten

Publikováno v: Medicine, 95(18). Lippincott Williams and Wilkins
Medicine, 95(18)
Medicine (Baltimore), 95, 18, pp. e3457
Medicine (Baltimore), 95(18). Lippincott Williams & Wilkins
Medicine
Medicine (Baltimore), 95, e3457

Contains fulltext : 167922.pdf (Publisher’s version ) (Open Access) Recently, treatment with MEK inhibitors has been shown to be an effective treatment option for metastatic melanoma. Treatment efficacy is dependent on inhibition of MAPK-related me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b78c952a37610d2181431f0537a32ee
https://hdl.handle.net/1887/112089

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