Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Mark J Tomishima"'
Autor:
Sivan Harel, Edmund Y Tu, Stuart Weisberg, Manuel Esquilin, Stuart M Chambers, Becky Liu, Christian T Carson, Lorenz Studer, Boris Reizis, Mark J Tomishima
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42302 (2012)
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) offer great promise in regenerative medicine and disease modeling due to their unlimited self-renewal and broad differentiation capacity. There is evidence that the growth propert
Externí odkaz:
https://doaj.org/article/392618b4656a4f26bb7abe9144d80fa9
Publikováno v:
Cell Reports, Vol 3, Iss 4, Pp 1140-1152 (2013)
Melanocytes are pigment-producing cells of neural crest (NC) origin that are responsible for protecting the skin against UV irradiation. Pluripotent stem cell (PSC) technology offers a promising approach for studying human melanocyte development and
Externí odkaz:
https://doaj.org/article/9a775af0b4554c619264df5fcdcc92e9
Autor:
Patrick Revy, Thomas G. P. Grunewald, Sandrine Grossetête, Mark J. Tomishima, Anna Sole, Isabelle Janoueix-Lerosey, Benjamin Renouf, Erika Brunet, Cécile Pierre-Eugène, Maxime Heintzé, Sophie Kaltenbach, Maria Jasin, Anne De Cian, Loelia Babin, Sakina Zaidi, Didier Surdez, Carine Giovannangeli, Olivier Delattre, Lucile Couronné
Publikováno v:
Cancer Res
Cancer Research
Cancer Research, 2021, 81 (19), pp.4994-5006. ⟨10.1158/0008-5472.CAN-20-3837⟩
Cancer Research, American Association for Cancer Research, 2021, 81 (19), pp.4994-5006. ⟨10.1158/0008-5472.CAN-20-3837⟩
Cancer Research
Cancer Research, 2021, 81 (19), pp.4994-5006. ⟨10.1158/0008-5472.CAN-20-3837⟩
Cancer Research, American Association for Cancer Research, 2021, 81 (19), pp.4994-5006. ⟨10.1158/0008-5472.CAN-20-3837⟩
Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing EWSR1 with FLI1. An estimated 30% of Ewing sarcoma tumors also display genetic alterations in STAG2, TP53, or CDKN2A (SPC). Numerous attempts to develop relevant E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5acc505da435aa12d5b62dcd658ece
https://www.zora.uzh.ch/id/eprint/212442/
https://www.zora.uzh.ch/id/eprint/212442/
Autor:
Brittany N. Dubose, Eugene V. Mosharov, Ellen J. Hill, So Yeon Koo, Viviane Tabar, Nicholas D. Socci, Susan Zabierowski, Jinghua Piao, Sonja Kriks, Sun Young Chung, Mark J. Tomishima, Se Joon Choi, Lorenz Studer, Tae Wan Kim, Stefan Irion, Doron Betel
Publikováno v:
Cell stem cell. 28(2)
Human pluripotent stem cells show considerable promise for applications in regenerative medicine, including the development of cell replacement paradigms for the treatment of Parkinson's disease. Protocols have been developed to generate authentic mi
Autor:
Mary L. Alpaugh, Thomas A. Neubert, Venkatraman E. Seshan, Chao Xu, Sun Young Chung, Hediye Erdjument-Bromage, Gabriela Chiosis, Ronald C. Henrickson, Sarah Kishinevsky, Suhasini Joshi, Bastian Zimmer, Alexander Bolaender, Carmen Inda, John Philip, Smit K. Shah, Faranak Fattahi, John Koren, Marcel Leist, Simon Gutbier, Davinder Sandhu, Mark J. Tomishima, Tai Wang, Tony Taldone, Christine Klein, Nathalie Saurat, Lorenz Studer, Elizabeth Chang, Steven S. Gross, Anna Rodina
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
Environmental and genetic risk factors contribute to Parkinson’s Disease (PD) pathogenesis and the associated midbrain dopamine (mDA) neuron loss. Here, we identify early PD pathogenic events by developing methodology that utilizes recent innovatio
Autor:
Raphael Lis, Ting Zhou, Brandoch D. Cook, Jenny Xiang, Todd Evans, Shuibing Chen, Mark J. Tomishima, Mona Khalaj, Zaniar Ghazizadeh, Zengrong Zhu, Ali Naji, Tuo Zhang, Sadaf Amin, Miguel Crespo, Manuradhi Perera, Chengyang Liu, Danwei Huangfu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes, reflecting a key function for this gene in pancreatic β-cell biology. Previous attempts to recapitulate disease-relevant phenotypes in GLIS3−/− β-like cells have been un
Autor:
Siera A. Rosen, Elisa de Stanchina, Chao Zhang, Karen G. Wong, Mark J. Tomishima, Franz-Josef Müller, Kiran Ramnarine, Sean D. Ryan, Amanda Kulick, Doron Betel, Thadeous J. Kacmarczyk, Shannon E. Mann
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 9, Iss 1, Pp 355-365 (2017)
Stem Cell Reports, Vol 9, Iss 1, Pp 355-365 (2017)
Summary Human pluripotent stem cells (PSCs) provide an unlimited cell source for cell therapies and disease modeling. Despite their enormous power, technical aspects have hampered reproducibility. Here, we describe a modification of PSC workflows tha
Autor:
Erika Brunet, Mark J. Tomishima, Fabio Vanoli, Khadija Lamribet, Loelia Babin, Weiran Feng, Maria Jasin
Publikováno v:
Proceedings of the National Academy of Sciences. 114:3696-3701
Significance Fusion genes resulting from recurrent chromosomal translocations are associated with several tumor types. Cell lines carrying translocations represent important models to study the oncogenic properties of fusion proteins and develop ther
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 72-82 (2017)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Cell replacement therapy in the nervous system has a rich history, with ∼40 years of research and ∼30 years of clinical experience. There is compelling evidence that appropriate cells can integrate and function in the dysfunctioning human nervous
Autor:
M. Zeeshan Ozair, Song-Hai Shi, Yosif Ganat, Nicolas Renier, Talia Atkin, Jason Tchieu, Faranak Fattahi, Joseph A. Gogos, Lorenz Studer, Mark J. Tomishima, Xin-Jun Zhang, Ziyi Sun, Ricardo Azevedo, Bastian Zimmer, Maria Karayiorgou, Zhuhao Wu, Marc Tessier-Lavigne, Ali H. Brivanlou, Yuchen Qi, Nadja Zeltner
Publikováno v:
Nature biotechnology
Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into functional neurons. However, the protracted timing of human neuron specification and functional maturation remains a key challenge that hampers the routine ap