Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mark J Pearson"'
Autor:
Andrew Filer, Philipp Antczak, Greg N Parsonage, Holly M Legault, Margot O'Toole, Mark J Pearson, Andrew M Thomas, Dagmar Scheel-Toellner, Karim Raza, Christopher D Buckley, Francesco Falciani
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120917 (2015)
Synovial fibroblasts in persistent inflammatory arthritis have been suggested to have parallels with cancer growth and wound healing, both of which involve a stereotypical serum response programme. We tested the hypothesis that a serum response progr
Externí odkaz:
https://doaj.org/article/e27e205633494cda815af25738c13856
Autor:
Megan E. Cooke, Mark J. Pearson, Richard J. A. Moakes, Christopher J. Weston, Edward T. Davis, Simon W. Jones, Liam M. Grover
Publikováno v:
APL Bioengineering, Vol 1, Iss 1, Pp 016104-016104-13 (2017)
Human articular chondrocytes lose their native phenotype when expanded in traditional monolayer cultures. As a consequence, hydrogel encapsulation has been investigated as a means to maintain the natural phenotype. Alginate has been widely used for c
Externí odkaz:
https://doaj.org/article/e2532017654442d3940152fab391da17
Autor:
Mark J. Pearson, Edward T. Davis, Mark A. Lindsay, Susanne N. Wijesinghe, Dominika E Nanus, Simon W. Jones, Marina R. Hadjicharalambous, Alex Rosser
Publikováno v:
Arthritis & Rheumatology. 72:609-619
To identify long noncoding RNAs (lncRNAs) associated with the inflammatory phenotype of synovial fibroblasts from obese patients with osteoarthritis (OA), and to explore the expression and function of these lncRNAs.Synovium was collected from normal-
Autor:
Ashleigh M. Philp, Megan E. Cooke, Simon W. Jones, Liam M. Grover, Hirah Haq, Thomas Nicholson, Matthew Newton Ede, Mark J. Pearson
Publikováno v:
Spine Deformity. 7:533-542
Study Design An observational descriptive study based on a single cohort of patients. Objective To determine whether spinal facet osteoblasts at the curve apex display a different phenotype to osteoblasts from outside the curve in adolescent idiopath
Autor:
Mark A. Lindsay, Dominika E Nanus, Edward T. Davis, Simon W. Jones, Mark J. Pearson, Marina R. Hadjicharalambous, Alex Rosser, Susanne N. Wijesinghe
Publikováno v:
Arthritis & Rheumatology. 72
Publikováno v:
HSS Journal ®. 13:20-27
Precision medicine has been adopted in a range of clinical settings where omics data have led to greater characterisation of disease and stratification of patients into subcategories of phenotypes and pathologies. However, in orthopaedics, precision
Autor:
Simon W. Jones, Mark J. Pearson
Publikováno v:
Arthritis & Rheumatology. 68:2575-2583
Autor:
Mark J, Pearson, Dietmar, Herndler-Brandstetter, Mohammad A, Tariq, Thomas A, Nicholson, Ashleigh M, Philp, Hannah L, Smith, Edward T, Davis, Simon W, Jones, Janet M, Lord
Publikováno v:
Scientific Reports
Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many patients with OA are obese and increased adiposity is associated with chronic inflammation, we inv
Publikováno v:
Osteoarthritis and Cartilage. 22(5):609-621
SummaryOsteoarthritis (OA) is an age-related condition and the leading cause of pain, disability and shortening of adult working life in the UK. The incidence of OA increases with age, with 25% of the over 50s population having OA of the knee. Despit
Publikováno v:
Biochemical and Biophysical Research Communications. 426:539-543
3' Untranslated regions (3'UTRs) of messenger RNAs have important roles in post-transcriptional regulation of gene expression and this is partly achieved through binding of specific proteins to sequences or structures within these regions. Previously