Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Mark J Henderson"'
Autor:
Lizhen Wu, Jian Cao, Wesley L Cai, Sabine M Lang, John R Horton, Daniel J Jansen, Zongzhi Z Liu, Jocelyn F Chen, Meiling Zhang, Bryan T Mott, Katherine Pohida, Ganesha Rai, Stephen C Kales, Mark J Henderson, Xin Hu, Ajit Jadhav, David J Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D Hall, Xiaodong Cheng, Gerald S Shadel, Qin Yan
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate
Externí odkaz:
https://doaj.org/article/b82bd2d7d5a04000a7a64e580355ce3f
Autor:
Yongwang Zhong, Jiou Wang, Mark J Henderson, Peixin Yang, Brian M Hagen, Teepu Siddique, Bruce E Vogel, Han-Xiang Deng, Shengyun Fang
Publikováno v:
eLife, Vol 6 (2017)
Over 170 different mutations in the gene encoding SOD1 all cause amyotrophic lateral sclerosis (ALS). Available studies have been primarily focused on the mechanisms underlying mutant SOD1 cytotoxicity. How cells defend against the cytotoxicity remai
Externí odkaz:
https://doaj.org/article/7385a4b9f6ca41dc809a49f0ef1d3d6e
Autor:
Emily S Wires, Mark J Henderson, Xiaokang Yan, Susanne Bäck, Kathleen A Trychta, Molly H Lutrey, Brandon K Harvey
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175481 (2017)
The endoplasmic reticulum (ER) is essential to many cellular processes including protein processing, lipid metabolism and calcium storage. The ability to longitudinally monitor ER homeostasis in the same organism would offer insight into progressive
Externí odkaz:
https://doaj.org/article/28b46d22dc31411cab9dc1b2884dec9d
Autor:
Mark J Henderson, Heather A Baldwin, Christopher A Werley, Stefano Boccardo, Leslie R Whitaker, Xiaokang Yan, Graham T Holt, Eric R Schreiter, Loren L Looger, Adam E Cohen, Douglas S Kim, Brandon K Harvey
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139273 (2015)
Endoplasmic reticulum calcium homeostasis is critical for cellular functions and is disrupted in diverse pathologies including neurodegeneration and cardiovascular disease. Owing to the high concentration of calcium within the ER, studying this subce
Externí odkaz:
https://doaj.org/article/161ea35e86594287bc3d469f5096851a
Autor:
América Chandía-Cristi, Daniela A. Gutiérrez, Andrés E. Dulcey, Marcelo Lara, Lina Vargas, Yi-Han Lin, Pablo Jimenez-Muñoz, Gabriela Larenas, Xin Xu, Amy Wang, Ashley Owens, Christopher Dextras, YuChi Chen, Claudio Pinto, Tamara Marín, Hugo Almarza-Salazar, Keryma Acevedo, Gonzalo I. Cancino, Xin Hu, Patricio Rojas, Marc Ferrer, Noel Southall, Mark J. Henderson, Silvana Zanlungo, Juan J. Marugan, Alejandra Álvarez R
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114144- (2024)
Summary: The molecular mechanisms underlying seizure generation remain elusive, yet they are crucial for developing effective treatments for epilepsy. The current study shows that inhibiting c-Abl tyrosine kinase prevents apoptosis, reduces dendritic
Externí odkaz:
https://doaj.org/article/d6f3af7f5f984ae686e586e3fd0a0393
Autor:
Wenjing Yan, Yongwang Zhong, Xin Hu, Tuan Xu, Yinghua Zhang, Stephen Kales, Yanyan Qu, Daniel C. Talley, Bolormaa Baljinnyam, Christopher A. LeClair, Anton Simeonov, Brian M. Polster, Ruili Huang, Yihong Ye, Ganesha Rai, Mark J. Henderson, Dingyin Tao, Shengyun Fang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins. Decreased or insufficient ubiquitination
Externí odkaz:
https://doaj.org/article/f3f674c5f7b14cfbb5a8b35c4adc9a3f
Autor:
Allan I. Paxson, Loren H. Chang, Jaime M. C. Gard, William L. Harryman, Colin S. Nelson, Stella B. Salmon, Kendra D. Marr, Leah M. Wachsmuth, Anita Ramanathan, Jing Ran, Abhijeet Kapoor, Juan J. Marugan, Mark J. Henderson, Tino W. Sanchez, Anne E. Cress
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
In 2023, approximately 288,300 new diagnoses of prostate cancer will occur, with 34,700 disease-related deaths. Death from prostate cancer is associated with metastasis, enabled by progression of tumor phenotypes and successful extracapsular extensio
Externí odkaz:
https://doaj.org/article/a456044366374dd1a817306440c69162
Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury
Autor:
Hannah Mason, Ganesha Rai, Arina Kozyr, Nathaniel De Jonge, Emily Gliniewicz, Lars J. Berg, Gal Wald, Cayce Dorrier, Mark J. Henderson, Alexey Zakharov, Tristan Dyson, John Audley, Anthony M. Pettinato, Elias Carvalho Padilha, Pranav Shah, Xin Xu, Thomas L. Leto, Anton Simeonov, Kol A. Zarember, Dorian B. McGavern, John I. Gallin
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102611- (2023)
NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction of ROS by these enzym
Externí odkaz:
https://doaj.org/article/31bbeff5a1be41638e89f840fa625181
Autor:
Michelle M. McClure, Melissa A. Haltuch, Ellen Willis-Norton, David D. Huff, Elliott L. Hazen, Lisa G. Crozier, Michael G. Jacox, Mark W. Nelson, Kelly S. Andrews, Lewis A.K. Barnett, Aaron M. Berger, Sabrina Beyer, Joe Bizzarro, David Boughton, Jason M. Cope, Mark Carr, Heidi Dewar, Edward Dick, Emmanis Dorval, Jason Dunham, Vladlena Gertseva, Correigh M. Greene, Richard G. Gustafson, Owen S. Hamel, Chris J. Harvey, Mark J. Henderson, Chris E. Jordan, Isaac C. Kaplan, Steven T. Lindley, Nathan J. Mantua, Sean E. Matson, Melissa H. Monk, Peter Moyle, Colin Nicol, John Pohl, Ryan R. Rykaczewski, Jameal F. Samhouri, Susan Sogard, Nick Tolimieri, John Wallace, Chantel Wetzel, Steven J. Bograd
Publikováno v:
Frontiers in Marine Science, Vol 10 (2023)
IntroductionUnderstanding how abundance, productivity and distribution of individual species may respond to climate change is a critical first step towards anticipating alterations in marine ecosystem structure and function, as well as developing str
Externí odkaz:
https://doaj.org/article/3a7c30a9d6264cdf83a127a3c655e1a2
Autor:
Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, Cris M. Brown, Punn Augsornworawat, Yoel Hirsch, Martin M. Johansson, Tzvi Weiden, Joseph Ekstein, Joshua Cohen, Justin Klee, Kent Leslie, Anton Simeonov, Mark J. Henderson, Jeffrey R. Millman, Fumihiko Urano
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revealed Wolfram
Externí odkaz:
https://doaj.org/article/24a5fd515d1d461683a1b821a7ee0008