Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Mark J Henderson"'
Autor:
América Chandía-Cristi, Daniela A. Gutiérrez, Andrés E. Dulcey, Marcelo Lara, Lina Vargas, Yi-Han Lin, Pablo Jimenez-Muñoz, Gabriela Larenas, Xin Xu, Amy Wang, Ashley Owens, Christopher Dextras, YuChi Chen, Claudio Pinto, Tamara Marín, Hugo Almarza-Salazar, Keryma Acevedo, Gonzalo I. Cancino, Xin Hu, Patricio Rojas, Marc Ferrer, Noel Southall, Mark J. Henderson, Silvana Zanlungo, Juan J. Marugan, Alejandra Álvarez R
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114144- (2024)
Summary: The molecular mechanisms underlying seizure generation remain elusive, yet they are crucial for developing effective treatments for epilepsy. The current study shows that inhibiting c-Abl tyrosine kinase prevents apoptosis, reduces dendritic
Externí odkaz:
https://doaj.org/article/d6f3af7f5f984ae686e586e3fd0a0393
Autor:
Wenjing Yan, Yongwang Zhong, Xin Hu, Tuan Xu, Yinghua Zhang, Stephen Kales, Yanyan Qu, Daniel C. Talley, Bolormaa Baljinnyam, Christopher A. LeClair, Anton Simeonov, Brian M. Polster, Ruili Huang, Yihong Ye, Ganesha Rai, Mark J. Henderson, Dingyin Tao, Shengyun Fang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins. Decreased or insufficient ubiquitination
Externí odkaz:
https://doaj.org/article/f3f674c5f7b14cfbb5a8b35c4adc9a3f
Autor:
Allan I. Paxson, Loren H. Chang, Jaime M. C. Gard, William L. Harryman, Colin S. Nelson, Stella B. Salmon, Kendra D. Marr, Leah M. Wachsmuth, Anita Ramanathan, Jing Ran, Abhijeet Kapoor, Juan J. Marugan, Mark J. Henderson, Tino W. Sanchez, Anne E. Cress
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
In 2023, approximately 288,300 new diagnoses of prostate cancer will occur, with 34,700 disease-related deaths. Death from prostate cancer is associated with metastasis, enabled by progression of tumor phenotypes and successful extracapsular extensio
Externí odkaz:
https://doaj.org/article/a456044366374dd1a817306440c69162
Autor:
Maria Esteban-Lopez, Kenneth J. Wilson, Courtney Myhr, Elena M. Kaftanovskaya, Mark J. Henderson, Noel T. Southall, Xin Xu, Amy Wang, Xin Hu, Elena Barnaeva, Wenjuan Ye, Emmett R. George, John T. Sherrill, Marc Ferrer, Roy Morello, Irina U. Agoulnik, Juan J. Marugan, Alexander I. Agoulnik
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Specific small molecule RXFP2 agonists with favorable pharmacokinetic properties induce gubernacular invagination in mouse embryos, increase mineralization activity in human osteoblasts in vitro, and improve bone trabecular parameters in adult mice.
Externí odkaz:
https://doaj.org/article/50c86baebeb04e3ebabf87beea0be0a0
Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury
Autor:
Hannah Mason, Ganesha Rai, Arina Kozyr, Nathaniel De Jonge, Emily Gliniewicz, Lars J. Berg, Gal Wald, Cayce Dorrier, Mark J. Henderson, Alexey Zakharov, Tristan Dyson, John Audley, Anthony M. Pettinato, Elias Carvalho Padilha, Pranav Shah, Xin Xu, Thomas L. Leto, Anton Simeonov, Kol A. Zarember, Dorian B. McGavern, John I. Gallin
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102611- (2023)
NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction of ROS by these enzym
Externí odkaz:
https://doaj.org/article/31bbeff5a1be41638e89f840fa625181
Autor:
Michelle M. McClure, Melissa A. Haltuch, Ellen Willis-Norton, David D. Huff, Elliott L. Hazen, Lisa G. Crozier, Michael G. Jacox, Mark W. Nelson, Kelly S. Andrews, Lewis A.K. Barnett, Aaron M. Berger, Sabrina Beyer, Joe Bizzarro, David Boughton, Jason M. Cope, Mark Carr, Heidi Dewar, Edward Dick, Emmanis Dorval, Jason Dunham, Vladlena Gertseva, Correigh M. Greene, Richard G. Gustafson, Owen S. Hamel, Chris J. Harvey, Mark J. Henderson, Chris E. Jordan, Isaac C. Kaplan, Steven T. Lindley, Nathan J. Mantua, Sean E. Matson, Melissa H. Monk, Peter Moyle, Colin Nicol, John Pohl, Ryan R. Rykaczewski, Jameal F. Samhouri, Susan Sogard, Nick Tolimieri, John Wallace, Chantel Wetzel, Steven J. Bograd
Publikováno v:
Frontiers in Marine Science, Vol 10 (2023)
IntroductionUnderstanding how abundance, productivity and distribution of individual species may respond to climate change is a critical first step towards anticipating alterations in marine ecosystem structure and function, as well as developing str
Externí odkaz:
https://doaj.org/article/3a7c30a9d6264cdf83a127a3c655e1a2
Publikováno v:
Journal of Synchrotron Radiation, Vol 29, Iss 2, Pp 281-287 (2022)
Stable actinide colloids and nanoparticles are of interest because of their potential to affect the transportation of radionuclides in the near-field of a nuclear waste repository. At high concentrations, thorium(IV) can precipitate to form intrinsic
Externí odkaz:
https://doaj.org/article/b220c36327e14885afa0da0eb73e96ac
Publikováno v:
Frontiers in Marine Science, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/e4a3b4eca8e74cf59c8a88e8c255be3e
Autor:
Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, Cris M. Brown, Punn Augsornworawat, Yoel Hirsch, Martin M. Johansson, Tzvi Weiden, Joseph Ekstein, Joshua Cohen, Justin Klee, Kent Leslie, Anton Simeonov, Mark J. Henderson, Jeffrey R. Millman, Fumihiko Urano
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revealed Wolfram
Externí odkaz:
https://doaj.org/article/24a5fd515d1d461683a1b821a7ee0008
Autor:
Md Kabir, Elias C. Padilha, Pranav Shah, Ruili Huang, Srilatha Sakamuru, Eric Gonzalez, Lin Ye, Xin Hu, Mark J. Henderson, Menghang Xia, Xin Xu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cytochrome P450 (CYP) 3A7 is one of the major xenobiotic metabolizing enzymes in human embryonic, fetal, and newborn liver. CYP3A7 expression has also been observed in a subset of the adult population, including pregnant women, as well as in various
Externí odkaz:
https://doaj.org/article/f9d354218d0943e386f9679ca6dac038