Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mark J H Simmons"'
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde). This work studies the diss
Externí odkaz:
https://doaj.org/article/a28df2e36d804c7d9e1be05512fe9968
Autor:
Konstantinos Stamatopoulos, Connor O’Farrell, Mark J. H. Simmons, Hannah K. Batchelor, Nena Mistry
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 882 (2023)
A physiologically based biopharmaceutic model (PBBM) of a modified-release formulation of theophylline (Uniphyllin Continus® 200 mg tablet) was developed and implemented to predict the pharmacokinetic (PK) data of healthy male volunteers by integrat
Externí odkaz:
https://doaj.org/article/971020ba2e1c4f99a5d83f9bf2223142
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2193 (2022)
The in vitro release of theophylline from an extended-release dosage form was studied under different hydrodynamic conditions in a United States Pharmacopoeial (USP) dissolution system II and a bespoke in vitro tubular model of the human colon, the D
Externí odkaz:
https://doaj.org/article/81af068eed1445bfb1774a0549b819c5
Autor:
Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos, Caroline L. Hoad, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor, Alessio Alexiadis
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1402 (2022)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/a147ba1016604bc4b9fe7911f6d82691
Autor:
Michael Schütt, Connor O’Farrell, Konstantinos Stamatopoulos, Caroline L. Hoad, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor, Alessio Alexiadis
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 184 (2022)
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic
Externí odkaz:
https://doaj.org/article/7613cdd0ba5543b0814e9a526b2a501f
Autor:
Connor O’Farrell, Caroline L. Hoad, Konstantinos Stamatopoulos, Luca Marciani, Sarah Sulaiman, Mark J. H. Simmons, Hannah K. Batchelor
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1545 (2021)
Knowledge of luminal flow inside the human colon remains elusive, despite its importance for the design of new colon-targeted drug delivery systems and physiologically relevant in silico models of dissolution mechanics within the colon. This study us
Externí odkaz:
https://doaj.org/article/68d9ca066dec4482b4222dd190fd60e2
Autor:
Nina M. Kovalchuk, Mark J. H. Simmons
Publikováno v:
Colloids and Interfaces, Vol 5, Iss 3, p 40 (2021)
Drops contained in an immiscible liquid phase are attractive as microreactors, enabling sound statistical analysis of reactions performed on ensembles of samples in a microfluidic device. Many applications have specific requirements for the values of
Externí odkaz:
https://doaj.org/article/9b306563d8f1445eb5cecbba866298b4
Autor:
Michael Schütt, Konstantinos Stamatopoulos, Hannah K. Batchelor, Mark J. H. Simmons, Alessio Alexiadis
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 859 (2021)
For colonic drug delivery, the ascending part of the colon is the most favourable site as it offers the most suitable environmental conditions for drug dissolution. Commonly, the performance of a drug formulation is assessed using standardised dissol
Externí odkaz:
https://doaj.org/article/040aebcb060243898227e41883db06ad
Autor:
Loïc Chagot, César Quilodrán-Casas, Maria Kalli, Nina M. Kovalchuk, Mark J. H. Simmons, Omar K. Matar, Rossella Arcucci, Panagiota Angeli
Publikováno v:
Lab on a Chip. 22:3848-3859
The control of droplet formation and size using microfluidic devices is a critical operation for both laboratory and industrial applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ea6dc7952bf5c118c6d3ce2ac27ff7
https://doi.org/10.1039/d2lc00416j
https://doi.org/10.1039/d2lc00416j
Autor:
Konstantinos Stamatopoulos, Sharad Karandikar, Mark Goldstein, Connor O’Farrell, Luca Marciani, Sarah Sulaiman, Caroline L. Hoad, Mark J. H. Simmons, Hannah K. Batchelor
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 659 (2020)
This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particl
Externí odkaz:
https://doaj.org/article/b84b4d5fab48443d81b7f955d4d3103c