Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mark J Demma"'
Autor:
Angie Sun, Brian Hall, Jennifer O'Neil, Abbas Walji, Claudio Mapelli, Michael J. Hohn, Mark J Demma
Publikováno v:
FEBS Letters. 594:1467-1476
Myc, a transcription factor with oncogenic activity, is upregulated by amplification, translocation, and mutation of the cellular pathways that regulate its stability. Inhibition of the Myc oncogene by various modalities has had limited success. One
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89bbf5ccd1517becdfa722df7872cc4a
https://doi.org/10.1002/1873-3468.13759
https://doi.org/10.1002/1873-3468.13759
Autor:
Abbas Walji, John Zelina, Federica Orvieto, Smaranda Bodea, Simona Altezza, Derek Wiswell, Mark J Demma, Shiying Chen, Jennifer O'Neil, Enrique Escandón, Eric S. Muise, Alessia Santoprete, Brian Hall, Claudio Mapelli, Benjamin Ruprecht, Angie Sun, Kallol Ray, Federica Tucci, Sarah Javaid
Publikováno v:
Molecular and Cellular Biology
The MYC oncogene is upregulated in human cancers by translocation, amplification, and mutation of cellular pathways that regulate Myc. Myc/Max heterodimers bind to E box sequences in the promoter regions of genes and activate transcription.
The
The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef31b9d6cd632d0e4db013eeb058b278
https://doi.org/10.1128/mcb.00248-19
https://doi.org/10.1128/mcb.00248-19
Autor:
Federica Orvieto, Mark J Demma, Canada Keith A, Alycia V Shoultz, Alessia Santoprete, Kuanchang Chen, Amy Bittner Mccracken, Xiaohong Zhu, Scott A. Johnson, Claudio Mapelli, Iman Farasat, Brian M. Lacey, Zachary Z Brown, Abbas Walji, Robert M. Garbaccio, Jennifer O'Neil, Elisabetta Bianchi
Publikováno v:
The Journal of organic chemistry. 85(3)
The Myc transcription factor represents an "undruggable" target of high biological interest due to its central role in various cancers. An abbreviated form of the c-Myc protein, called Omomyc, consists of the Myc DNA-binding domain and a coiled-coil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbde67858f848c479c02eb0d491b7bd
https://pubmed.ncbi.nlm.nih.gov/31660743
https://pubmed.ncbi.nlm.nih.gov/31660743