Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mark J Bucsek"'
Autor:
Fumito Ito, Amy W Ku, Mark J Bucsek, Jason B Muhitch, Trupti Vardam-Kaur, Minhyung Kim, Daniel T Fisher, Marta Camoriano, Thaer Khoury, Joseph J Skitzki, Sandra O Gollnick, Sharon S Evans
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143370 (2015)
While surgical resection is a cornerstone of cancer treatment, local and distant recurrences continue to adversely affect outcome in a significant proportion of patients. Evidence that an alternative debulking strategy involving radiofrequency ablati
Externí odkaz:
https://doaj.org/article/30ddd6b0e3464a5daa61095a99011bf2
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29226 (2011)
Despite the initial promise of myoblast transfer therapy to restore dystrophin in Duchenne muscular dystrophy patients, clinical efficacy has been limited, primarily by poor cell survival post-transplantation. Murine muscle derived stem cells (MDSCs)
Externí odkaz:
https://doaj.org/article/806eebe7fe7a48ebbc0634098045e49e
Autor:
Elizabeth A. Repasky, Joseph J. Barbi, Bonnie L. Hylander, Mark J. Bucsek, Cameron R. MacDonald, Hemn Mohammadpour, Minhui Chen, Guanxi Qiao
Metabolic dysfunction and exhaustion in tumor-infiltrating T cells have been linked to ineffectual antitumor immunity and the failure of immune checkpoint inhibitor therapy. We report here that chronic stress plays a previously unrecognized role in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d146c388aad554791599fa240ff3dc1
https://doi.org/10.1158/2326-6066.c.6550284.v1
https://doi.org/10.1158/2326-6066.c.6550284.v1
Autor:
Elizabeth A. Repasky, Joseph J. Barbi, Bonnie L. Hylander, Mark J. Bucsek, Cameron R. MacDonald, Hemn Mohammadpour, Minhui Chen, Guanxi Qiao
Supplementary Figures 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5a0fef03c4032acbebea221da6a69d
https://doi.org/10.1158/2326-6066.22543479
https://doi.org/10.1158/2326-6066.22543479
Autor:
Elizabeth A. Repasky, Joseph J. Barbi, Bonnie L. Hylander, Mark J. Bucsek, Cameron R. MacDonald, Hemn Mohammadpour, Minhui Chen, Guanxi Qiao
Supplementary table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5328d2b8f32112fccd9a3f08af0eeb
https://doi.org/10.1158/2326-6066.22543476.v1
https://doi.org/10.1158/2326-6066.22543476.v1
Autor:
Elizabeth A. Repasky, Bonnie L. Hylander, Scott I. Abrams, Kristopher Attwood, Michelle N. Messmer, Jason W.-L. Eng, Kathleen M. Kokolus, Haichao Liu, Brian Niedzwecki, Lauren Evans, Thejaswini Giridharan, Cameron R. MacDonald, Guanxi Qiao, Mark J. Bucsek
This data shows that housing mice at 30 degrees Celsius improves the efficacy of anti-PD-1 in both 4T1 and B16-OVA tumor-bearing mice indicating that cool housing temperatures (22 degrees C) impairs the efficacy of anti-PD-1 in murine tumor models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600baffff9aca5eeba91cd8561516aec
https://doi.org/10.1158/0008-5472.22414770
https://doi.org/10.1158/0008-5472.22414770
Autor:
Marc S. Ernstoff, Elizabeth A. Repasky, Hemn Mohammadpour, Igor Puzanov, Mark J. Bucsek, Joseph J. Drabick, Pauline Funchain, Suzanne Stack, Maria Levis, Carlos D. Cedeno, Paul K. Wallace, Joseph D. Tario, Cheryl Allen, Erik S. Knudsen, Agnieszka K. Witkiewicz, Wenyan Ji, Kristopher Attwood, Manu R. Pandey, Shipra Gandhi
Percentage of cells (m-MDSC, PMN-MDSC, T regulatory cells, T helper cells, cytotoxic T-cells, PD-L1+ melanoma cells, activated, partially exhausted and exhausted CD8+ T-cells) in archival tissue biopsies for 8/9 patients in the regions of interest se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3333b656ab50921443882088125c9141
https://doi.org/10.1158/1078-0432.22479656
https://doi.org/10.1158/1078-0432.22479656
Autor:
Marc S. Ernstoff, Elizabeth A. Repasky, Hemn Mohammadpour, Igor Puzanov, Mark J. Bucsek, Joseph J. Drabick, Pauline Funchain, Suzanne Stack, Maria Levis, Carlos D. Cedeno, Paul K. Wallace, Joseph D. Tario, Cheryl Allen, Erik S. Knudsen, Agnieszka K. Witkiewicz, Wenyan Ji, Kristopher Attwood, Manu R. Pandey, Shipra Gandhi
Purpose:Increased β-adrenergic receptor (β-AR) signaling has been shown to promote the creation of an immunosuppressive tumor microenvironment (TME). Preclinical studies have shown that abrogation of this signaling pathway, particularly β2-AR, pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0cf653fa4edd6225129efd7a070035
https://doi.org/10.1158/1078-0432.c.6530279
https://doi.org/10.1158/1078-0432.c.6530279
Autor:
Marc S. Ernstoff, Elizabeth A. Repasky, Hemn Mohammadpour, Igor Puzanov, Mark J. Bucsek, Joseph J. Drabick, Pauline Funchain, Suzanne Stack, Maria Levis, Carlos D. Cedeno, Paul K. Wallace, Joseph D. Tario, Cheryl Allen, Erik S. Knudsen, Agnieszka K. Witkiewicz, Wenyan Ji, Kristopher Attwood, Manu R. Pandey, Shipra Gandhi
Biomarker changes over time. A, Variations in chemokines IP-10, eotaxin and TNF-β in pg/ml. B, Variation in CD8+T-cells, m-MDSC, PMN-MDSC, regulatory T-cells (Tregs) expressed as percentage of total CD45+ cells, ratio of CD8+/ PMN-MDSC. C, Relative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bba82a991ef68699acf3f7fb487225
https://doi.org/10.1158/1078-0432.22479677.v1
https://doi.org/10.1158/1078-0432.22479677.v1
Autor:
Elizabeth A. Repasky, Bonnie L. Hylander, Scott I. Abrams, Kristopher Attwood, Michelle N. Messmer, Jason W.-L. Eng, Kathleen M. Kokolus, Haichao Liu, Brian Niedzwecki, Lauren Evans, Thejaswini Giridharan, Cameron R. MacDonald, Guanxi Qiao, Mark J. Bucsek
The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We report here that CD8+ T-cell frequency and functional orientation within the tumor microenviron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec282661638d66a258465c3d3cac9c3
https://doi.org/10.1158/0008-5472.c.6509076.v1
https://doi.org/10.1158/0008-5472.c.6509076.v1