Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mark J Althoff"'
Autor:
Mohd Minhajuddin, Amanda Winters, Haobin Ye, Shanshan Pei, Brett Stevens, Austin Gillen, Krysta Engel, Stephanie Gipson, Monica Ransom, Maria Amaya, Anagha Inguva, Maura Gasparetto, Mark J. Althoff, Regan Miller, Ian Shelton, Hunter Tolison, Anna Krug, Rachel Culp-Hill, Angelo D’Alessandro, Daniel W Sherbenou, Daniel A. Pollyea, Clayton Smith, Craig T Jordan
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
The treatment of blast phase chronic myeloid leukemia (bpCML) remains a challenge due at least in part to drug resistance of leukemia stem cells (LSCs). Recent clinical evidence suggests that the BCL-2 inhibitor venetoclax in combination with ABL-tar
Externí odkaz:
https://doaj.org/article/1e698dc2b5034f73b534561525fe0273
Autor:
Tali Dadosh, Breanna Bohan, Hassan Massalha, Eman Khatib-Massalha, Ashley M Wellendorf, Abhishek Singh, Mruniya V. Gawali, Smadar Levin-Zaidman, Orit Kollet, Tsvee Lapidot, Ekaterina Petrovich-Kopitman, Karin Golan, Mark J Althoff, Jose A. Cancelas, Mayla Bertagna, Biplab Dasgupta
Publikováno v:
Blood. 136:2607-2619
The fate of hematopoietic stem and progenitor cells (HSPC) is tightly regulated by their bone marrow (BM) microenvironment (ME). BM transplantation (BMT) frequently requires irradiation preconditioning to ablate endogenous hematopoietic cells. Whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6562a78bbb56baaa50dd4ff161eb2dd2
https://doi.org/10.1182/blood.2020005399
https://doi.org/10.1182/blood.2020005399
Autor:
Anagha Inguva, Krysta L. Engel, Hunter Tolison, Mark J Althoff, Shanshan Pei, Maria L. Amaya, Anna Krug, Mohammad Minhajuddin, Courtney L Jones, Austin E. Gillen, Monica Ransom, Sarah Staggs, Daniel A. Pollyea, Clayton Smith, Brett M. Stevens, Craig T. Jordan
Publikováno v:
Blood. 140:5922-5923
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0de511650d2f5299bb4585a99b704595
https://doi.org/10.1182/blood-2022-167787
https://doi.org/10.1182/blood-2022-167787
Autor:
Marie-Dominique Filippi, Q. Richard Lu, Jorge Moscat, Breanna Bohan, Maria T. Diaz-Meco, Yi Zheng, Hartmut Geiger, Ashley M Wellendorf, Mei Xin, Mark J Althoff, Jose A. Cancelas, Shailaja Hegde, Ramesh C. Nayak
Publikováno v:
Blood
Yap1 and its paralogue Taz largely control epithelial tissue growth. We have identified that hematopoietic stem cell (HSC) fitness response to stress depends on Yap1 and Taz. Deletion of Yap1 and Taz induces a loss of HSC quiescence, symmetric self-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348d6c585183aab4968539774e68141a
https://europepmc.org/articles/PMC7568035/
https://europepmc.org/articles/PMC7568035/
Publikováno v:
Blood. 138:299-299
Hematopoietic stem cells (HSC) are highly quiescent cells with the ability to rapidly enter cell cycle and differentiate through changes in their polarity and the disposition of intracellular molecular fate determinants in response to microenvironmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf561505820df84bac56ebb383a8b1ce
https://doi.org/10.1182/blood-2021-151046
https://doi.org/10.1182/blood-2021-151046
Autor:
S. Hegde, Ashley M Wellendorf, Damien Reynaud, John P. Perentesis, Miguel Reina-Campos, Yi Zheng, Mark J Althoff, Ramesh C. Nayak, Fatima Mohmoud, Maria T. Diaz-Meco, Jorge Moscat, Jose A. Cancelas
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Epigenetically regulated transcriptional plasticity has been proposed as a mechanism of differentiation arrest and resistance to therapy. BCR-ABL leukemias result from leukemic stem cell/progenitor transformation and represent an opportunity to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c602da0e4e05d78917f0682bf5647a14
http://europepmc.org/articles/PMC6320370
http://europepmc.org/articles/PMC6320370
Autor:
John Anastasi, Toshihiko Imamura, Shan Lin, Ahmad Rayes, Mark J Althoff, James C. Mulloy, Salam A. Assi, Anetta Ptasinska, Constanze Bonifer, Michael J. Thirman, Maureen M. O'Brien, Joseph J. Kaberlein, Roger T. Luo, Jon Kerry, Amom Ruhikanta Meetei, Thomas A. Milne, Mark Wunderlich
Publikováno v:
Cancer Cell. 30:737-749
The t(4;11)(q21;q23) fuses mixed-lineage leukemia (MLL) to AF4, the most common MLL-fusion partner. Here we show that MLL fused to murine Af4, highly conserved with human AF4, produces high-titer retrovirus permitting efficient transduction of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804ea5bcf535184bf9d371a29b634b19
https://doi.org/10.1016/j.ccell.2016.10.008
https://doi.org/10.1016/j.ccell.2016.10.008
PURPOSE OF REVIEW: Functional decline of hematopoiesis that occurs in the elderly, or in patients who receive therapies that trigger cellular senescence effects, results in a progressive reduction in the immune response and an increased incidence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7232c8a62a72d42575fe4f52e78d0c8
https://europepmc.org/articles/PMC6709869/
https://europepmc.org/articles/PMC6709869/
Autor:
Mark J Althoff, Yi Zheng, Ashley M Wellendorf, Jose A. Cancelas, Gang Huang, Shailaja Hegde, Maria T. Diaz-Meco, Ramesh C. Nayak, Fatima Mohmoud, Jorge Moscat
Publikováno v:
Blood. 132:551-551
Despite the introduction of tyrosine kinase inhibitor and CAR-T cell therapies, the prognosis for Ph+ and Ph-like acute lymphoblastic leukemia remains poor. In the present study, we show the role of the Scribble protein in both lymphoid and myeloid l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d05959e166619a277599cb6d2c731608
https://doi.org/10.1182/blood-2018-99-118919
https://doi.org/10.1182/blood-2018-99-118919
Autor:
Abhishek Singh, Mark J Althoff, Mayla Bertagna, Ekaterina Petrovich-Kopitman, Tsvee Lapidot, Luis C. Barrio, Fatima Mohmoud, Daniel González-Nieto, Jose A. Cancelas, Karin Golan, Ashley M Wellendorf
Publikováno v:
Blood. 132:872-872
Hematopoietic stem cell/progenitor (HSCP) transplantation (HSCT) is routinely used for the treatment of cancer and inborn hematopoietic defects. The bone marrow (BM) microenvironment (ME) is a major regulator of hematopoietic function and fate. Clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b93873e0b0708c6a061bc6775769fb
https://doi.org/10.1182/blood-2018-99-118292
https://doi.org/10.1182/blood-2018-99-118292