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of 13
pro vyhledávání: '"Mark J, Walport"'
Autor:
Anne E Bygrave, Kirsten L Rose, Josefina Cortes-Hernandez, Joanna Warren, Robert J Rigby, H Terence Cook, Mark J Walport, Timothy J Vyse, Marina Botto
Publikováno v:
PLoS Biology, Vol 2, Iss 8, p E243 (2004)
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of gene-targeted mice have been reported to develop SLE, implicating the null genes in the causation of d
Externí odkaz:
https://doaj.org/article/19d827a3c11d468198d439a72b208cc6
Autor:
Jeremy Farrar, Mark J Walport, Trevor Mundel, David L Heymann, Christopher J. M. Whitty, Sally C. Davies
Publikováno v:
Lancet (London, England)
Autor:
Maxine B. Hogarth, Jason H. Slingsby, Penelope J. Allen, E. Mary Thompson, Phillip Chandler, Kevin A. Davies, Elizabeth Simpson, Bernard J. Morley, Mark J. Walport
Publikováno v:
The Journal of Immunology. 161:2753-2761
BXSB mice spontaneously develop a lupus-like syndrome that is accelerated by the Yaa gene (Y-linked autoimmune accelerator). We studied the phenotype of disease in (B10 × BXSB)F1 and (BXSB × (B10 × BXSB)F1) backcross mice and genotyped 224 backcro
Publikováno v:
The Journal of Immunology. 160:4353-4360
The 5′-sequences flanking the human complement component C4 genes (C4A and C4B) have been analyzed for their ability to direct expression of a reporter gene in cell lines that constitutively express or do not express C4. No difference in the level
Autor:
Marina Botto, Mark J. Walport
The complement system consists of over 20 distinct proteins and is an essential component of the innate immune system. It is a major effector mechanism of host defence against infection and inflammatory responses, has an important role in the physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f913cc46633d943f3d2c9c8fc31d257
https://doi.org/10.1093/med/9780199204854.003.050102
https://doi.org/10.1093/med/9780199204854.003.050102
Autor:
Justin C. Mason, Mark J. Walport
Publikováno v:
Current Opinion in Orthopaedics. 3:54-59
Autor:
Anthony P, Manderson, Francesco, Carlucci, Peter J, Lachmann, Robert A, Lazarus, Richard J, Festenstein, H Terence, Cook, Mark J, Walport, Marina, Botto
Publikováno v:
Arthritis Research & Therapy
Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiquitous antigens, especially nuclear components. Evidence makes it clear that the development of these autoantibodies is an antigen-driven process and
Autor:
Mark J, Walport, David W, Lynn
Publikováno v:
Nature reviews. Molecular cell biology. 6(4)
In July 2004, the UK government published a 10-year science and innovation framework aimed at providing a more strategic, partnership-based approach to delivering science. With the aim of creating a UK society that is confident about the governance,
Autor:
Philip R, Taylor, Matthew C, Pickering, Marie H, Kosco-Vilbois, Mark J, Walport, Marina, Botto, Siamon, Gordon, Luisa, Martinez-Pomares
Publikováno v:
European journal of immunology. 32(7)
We have identified the murine follicular dendritic cell (FDC) marker, FDC-M2, recognized by monoclonal antibody mAb209, as complement component C4. Consistent with this, FDC-M2 was detectable at sites of immune complex-mediated inflammatory disease.
Autor:
Mark J, Walport
Publikováno v:
Arthritis Research
Chapter summary Complement is implicated in the pathogenesis of systemic lupus erythematosus (SLE) in several ways and may act as both friend and foe. Homozygous deficiency of any of the proteins of the classical pathway is causally associated with s