Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Mark J, Shlomchik"'
Autor:
Mark J Shlomchik, Claire Leibler, Shinu John, Shuchi Smita, Rachael Gordon, Sebastien Gingras, Sheldon Bastacky, Kensuke Miyake, Rebecca A Elsner, Kayla B Thomas, Stephen Joachim, Russell C Levack, Derrick Callahan, Ryutaro Fukui, Kevin M Nickerson
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/7e866731d48b4a219781ba0c08e5ac84
Autor:
Haylee A. Cosgrove, Sebastien Gingras, Minjung Kim, Sheldon Bastacky, Jeremy S. Tilstra, Mark J. Shlomchik
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
The endosomal Toll-like receptor 7 (TLR7) is a major driver of murine and human systemic lupus erythematosus (SLE). The role of TLR7 in lupus pathogenesis is enhanced when the regulatory role of TLR9 is absent. TLR7 signaling in plasmacytoid DCs (pDC
Externí odkaz:
https://doaj.org/article/4b6317968eb343848419b89127f8584f
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/16a3635a5e904b7eacfb6a8bc89b58fe
Autor:
Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina, Johan Rönnelid, Günter Steiner, Karl Skriner
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-16 (2021)
Abstract Background There is a need for biomarker to identify patients “at risk” for rheumatoid arthritis (risk-RA) and to better predict the therapeutic response and in this study we tested the hypothesis that novel native and citrullinated hete
Externí odkaz:
https://doaj.org/article/6e28ab54dbcf4c858aedc3ba90e27fcf
Autor:
Rachael A. Gordon, Christina Giannouli, Chirag Raparia, Sheldon I. Bastacky, Anthony Marinov, William Hawse, Richard Cattley, Jeremy S. Tilstra, Allison M. Campbell, Kevin M. Nickerson, Anne Davidson, Mark J. Shlomchik
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
NADPH oxidase deficiency exacerbates lupus in murine models and patients, but the mechanisms remain unknown. It is hypothesized that NADPH oxidase suppresses autoimmunity by facilitating dead cell clearance via LC3-associated phagocytosis (LAP). The
Externí odkaz:
https://doaj.org/article/3c1ff191a0484eb9a817b3dcb6dde47f
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
We previously found that kidney-infiltrating T cells (KITs) in murine lupus nephritis (LN) resembled dysfunctional T cells that infiltrate tumors. This unexpected finding raised the question of how to reconcile the “exhausted” phenotype of KITs w
Externí odkaz:
https://doaj.org/article/ef93804a4bec45d1985cd36146dcc059
Autor:
Mark J Shlomchik, Jeremy Tilstra, Claire Leibler, Shinu John, Kayla Thomas, Shuchi Smita, Rachael Gordon, Sebastien Gingras, Sheldon Bastacky, Kevin Nickerson
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/ef5c1f2c803245258c493e45c352c84a
Autor:
Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina, Johan Rönnelid, Günter Steiner, Karl Skriner
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/c6a3f6ea4dc34591a50ebdb7f3693e1d
Autor:
Rachael A Gordon, Jeremy S Tilstra, Anthony Marinov, Kevin M Nickerson, Sheldon I Bastacky, Mark J Shlomchik
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0226396 (2020)
Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of autoantigen in lupus remains elusive, a compelling hypothetical source is dead cell debris that drive
Externí odkaz:
https://doaj.org/article/85e463fd0b2544e280c52de750b2e124
Autor:
Rebecca A. Elsner, Mark J. Shlomchik
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2796-2809.e5 (2019)
Summary: Germinal centers (GC) are crucial for the formation of long-lived humoral immunity. Many pathogens suppress GC, including Salmonella enterica serovar Typhimurium (STm), but the mechanisms driving suppression remain unknown. We report that ne
Externí odkaz:
https://doaj.org/article/81dd2af310774450b462c3fc98fa5b97