Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Mark J, Routbort"'
Autor:
C. Cameron Yin, Wayne Tam, Serena M. Walker, Amandeep Kaur, Madhu M. Ouseph, Wei Xie, Olga K.Weinberg, Peng Li, Zhuang Zuo, Mark J. Routbort, Simon Chen, L. Jeffrey Medeiros, Tracy I George, Attilio Orazi, Daniel A. Arber, Adam Bagg, Robert P. Hasserjian, Sa A. Wang
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
STAT5B has been reported as a recurrent mutation in myeloid neoplasms with eosinophilia, but its overall frequency and importance across a spectrum of myeloid neoplasms are largely unknown. We conducted a multicenter study on a series of 82 myeloid n
Externí odkaz:
https://doaj.org/article/d278b8f93dc24bc5a9ea8b492101f78d
Autor:
Lingzhi Hong, Muhammad Aminu, Shenduo Li, Xuetao Lu, Milena Petranovic, Maliazurina B. Saad, Pingjun Chen, Kang Qin, Susan Varghese, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, Amy Spelman, Yasir Y. Elamin, Marcelo V. Negrao, Ferdinandos Skoulidis, Carl M. Gay, Tina Cascone, Saumil J. Gandhi, Steven H. Lin, Percy P. Lee, Brett W. Carter, Carol C. Wu, Mara B. Antonoff, Boris Sepesi, Jeff Lewis, Don L. Gibbons, Ara A. Vaporciyan, Xiuning Le, J. Jack Lee, Sinchita Roy-Chowdhuri, Mark J. Routbort, Justin F. Gainor, John V. Heymach, Yanyan Lou, Jia Wu, Jianjun Zhang, Natalie I. Vokes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Immune checkpoint inhibitors with or without chemotherapy are now standard of care for non-small cell lung cancer. However, the benefits of combination vs sequential therapy have not been fully explored. Here, the authors analysed 1,133 patient recor
Externí odkaz:
https://doaj.org/article/8e4eb1b2cf4847c68859d771395453bd
Autor:
Hui Chen, Qingqing Ding, Laila Khazai, Li Zhao, Senthil Damodaran, Jennifer K. Litton, Gaiane M. Rauch, Clinton Yam, Jeffrey T. Chang, Sahil Seth, Bora Lim, Alastair M. Thompson, Elizabeth A. Mittendorf, Beatriz Adrada, Kiran Virani, Jason B. White, Elizabeth Ravenberg, Xingzhi Song, Rosalind Candelaria, Banu Arun, Naoto T. Ueno, Lumarie Santiago, Sadia Saleem, Sausan Abouharb, Rashmi K. Murthy, Nuhad Ibrahim, Mark J. Routbort, Aysegul Sahin, Vicente Valero, William Fraser Symmans, Debu Tripathy, Wei-Lien Wang, Stacy Moulder, Lei Huo
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Background: Recent advances have been made in targeting the phosphoinositide 3-kinase pathway in breast cancer. Phosphatase and tensin homolog (PTEN) is a key component of that pathway. Objective: To understand the changes in PTEN expression over the
Externí odkaz:
https://doaj.org/article/d6308ee798424003bf82ce6d0277871d
Autor:
Rashmi Kanagal-Shamanna, Guillermo Montalban-Bravo, Panagiotis Katsonis, Koji Sasaki, Caleb A. Class, Elias Jabbour, David Sallman, Anthony Michael Hunter, Christopher Benton, Kelly S. Chien, Rajyalakshmi Luthra, Carlos E. Bueso-Ramos, Tapan Kadia, Michael Andreeff, Rami S. Komrokji, Najla H Al Ali, Nicholas Short, Naval Daver, Mark J. Routbort, Joseph D. Khoury, Keyur Patel, Irene Ganan-Gomez, Yue Wei, Gautam Borthakur, Farhad Ravandi, Kim-Anh Do, Kelly A. Soltysiak, Olivier Lichtarge, L. Jeffrey Medeiros, Hagop Kantarjian, Guillermo Garcia-Manero
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 3, Pp 1-5 (2021)
Externí odkaz:
https://doaj.org/article/d441753451c843299b7592b75c6d1078
Autor:
Ali Sakhdari, Beenu Thakral, Sanam Loghavi, Rashmi Kanagal‐Shamanna, C. Cameron Yin, Zhuang Zuo, Mark J. Routbort, Rajyalakshmi Luthra, L. Jeffrey Medeiros, Sa A. Wang, Keyur P. Patel, Chi Young Ok
Publikováno v:
Cancer Medicine, Vol 9, Iss 3, Pp 849-858 (2020)
Abstract Adult T‐cell acute lymphoblastic leukemia (T‐ALL) is a heterogeneous group of acute leukemias that account for about one third of all cases of Philadelphia chromosome (Ph)‐negative ALL. Recently, a molecular classifier using the mutati
Externí odkaz:
https://doaj.org/article/41270e5e14a045b5b36521d561471170
Autor:
Roberto Ruiz-Cordero, Junsheng Ma, Abha Khanna, Genevieve Lyons, Waree Rinsurongkawong, Roland Bassett, Ming Guo, Mark J. Routbort, Jianjun Zhang, Ferdinandos Skoulidis, John Heymach, Emily B. Roarty, Zhenya Tang, L. Jeffrey Medeiros, Keyur P. Patel, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Gene expression profiling has consistently identified three molecular subtypes of lung adenocarcinoma that have prognostic implications. To facilitate stratification of patients with this disease into similar molecular subtypes, w
Externí odkaz:
https://doaj.org/article/42cefdfcb2d246fca49bdc40bb094420
Autor:
Zhuang Zuo, L. Jeffrey Medeiros, Sofia Garces, Mark J. Routbort, Chi Young Ok, Sanam Loghavi, Rashmi Kanagal-Shamanna, Fatima Zahra Jelloul, Guillermo Garcia-Manero, Kelly S. Chien, Keyur P. Patel, Rajyalakshmi Luthra, C. Cameron Yin
Publikováno v:
Biology, Vol 12, Iss 1, p 13 (2022)
It has been reported that gene mutations in SF3B1 and PHF6 are mutually exclusive. However, this observation has never been rigorously assessed. We report the clinicopathologic and molecular genetic features of 21 cases of myeloid neoplasms with doub
Externí odkaz:
https://doaj.org/article/584dd1f056e34ae3afbdf575c030f774
ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants
Autor:
Xi Luo, Simone Feurstein, Shruthi Mohan, Christopher C. Porter, Sarah A. Jackson, Sioban Keel, Michael Chicka, Anna L. Brown, Chimene Kesserwan, Anupriya Agarwal, Minjie Luo, Zejuan Li, Justyne E. Ross, Panagiotis Baliakas, Daniel Pineda-Alvarez, Courtney D. DiNardo, Alison A. Bertuch, Nikita Mehta, Tom Vulliamy, Ying Wang, Kim E. Nichols, Luca Malcovati, Michael F. Walsh, Lesley H. Rawlings, Shannon K. McWeeney, Jean Soulier, Anna Raimbault, Mark J. Routbort, Liying Zhang, Gabriella Ryan, Nancy A. Speck, Sharon E. Plon, David Wu, Lucy A. Godley
Publikováno v:
Blood Advances, Vol 3, Iss 20, Pp 2962-2979 (2019)
Abstract: Standardized variant curation is essential for clinical care recommendations for patients with inherited disorders. Clinical Genome Resource (ClinGen) variant curation expert panels are developing disease-associated gene specifications usin
Externí odkaz:
https://doaj.org/article/147cccd407e042c69af7b468c729162f
Autor:
Sarah A. Bannon, Mark J. Routbort, Guillermo Montalban-Bravo, Rohtesh S. Mehta, Fatima Zahra Jelloul, Koichi Takahashi, Naval Daver, Betul Oran, Naveen Pemmaraju, Gautam Borthakur, Kiran Naqvi, Ghayas Issa, Koji Sasaki, Yesid Alvarado, Tapan M. Kadia, Marina Konopleva, Rashmi Kanagal Shamanna, Joseph D. Khoury, Farhad Ravandi, Richard Champlin, Hagop M. Kantarjian, Kapil Bhalla, Guillermo Garcia-Manero, Keyur P. Patel, Courtney D. DiNardo
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Previously considered rare, inherited hematologic malignancies are increasingly identified. Germline mutations in the RNA helicase DDX41 predispose to increased lifetime risks of myeloid neoplasms with disease often occurring later in life which pres
Externí odkaz:
https://doaj.org/article/87db5289a8f34dd4911b16e584a2bd98
Autor:
Sanam Loghavi, Dawen Sui, Peng Wei, Guillermo Garcia-Manero, Sherry Pierce, Mark J. Routbort, Elias J. Jabbour, Naveen Pemmaraju, Rashmi Kanagal-Shamanna, H. Deniz Gur, Shimin Hu, Zhuang Zuo, L. Jeffrey Medeiros, Hagop M. Kantarjian, Joseph D. Khoury
Publikováno v:
Blood Advances, Vol 2, Iss 15, Pp 1807-1816 (2018)
Abstract: The 2017 revision of the World Health Organization (WHO) classification includes substantial changes to the subclassification of chronic myelomonocytic leukemia (CMML): (1) a 3-tiered blast-based scheme including a novel “CMML-0” catego
Externí odkaz:
https://doaj.org/article/07388ba1715341c5967afddebb0733f8