Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mark J, Harding"'
Publikováno v:
Alcoholism: Clinical and Experimental Research. 46:2191-2202
Endophenotypes for alcohol use disorder are well known and may reflect paternal exposure effects passed down to offspring via epigenetic mechanisms. Previously, we showed that paternal alcohol exposure prior to conception attenuates the acquisition o
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2547
Drug addiction is a serious relapsing disease that has high costs to society and to the individual addicts. Treatment of these addictions is still in its nascency, with only a few examples of successful therapies. Therapeutic response depends upon ge
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625729
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce88c2e8928ade000c3b065b6484a5e6
https://doi.org/10.1007/978-1-0716-2573-6_16
https://doi.org/10.1007/978-1-0716-2573-6_16
Autor:
David A. Nielsen, Colin N. Haile, Cana B. Quave, Mark J. Harding, Richard A Meisch, Therese A. Kosten, Steven J. Nieto
Publikováno v:
Addict Biol
Familial transmission of alcohol use disorder reflects genetic and environmental factors. Paternal alcohol exposure may affect rodent offspring via epigenetic modifications transmitted through the male germ line. While such exposure alters alcohol se
Autor:
An Ye, Sara C. Hamon, David A. Nielsen, Mark J. Harding, Catherine J. Spellicy, Michelle A. Patriquin, Thomas R. Kosten, Ellen M. Nielsen, Patrick S. Thomas
Publikováno v:
Psychiatr Genet
OBJECTIVE: Prior research demonstrated that the δ-opioid receptor (OPRD1) rs678849 variant influences opioid use in African Americans treated with methadone. We examined whether this variant moderated cocaine and opioid use in our clinical cohort of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98a0b2785052e615c87cd67ed25e104
https://europepmc.org/articles/PMC8108700/
https://europepmc.org/articles/PMC8108700/
Publikováno v:
Behav Brain Res
Genetic variation in the serotonin transporter (SLC6A4) has been shown to moderate the acute subjective effects of cocaine. Methylation of the SLC6A4 gene is associated with decreased transcription of the serotonin transporter, leading to increased s
Autor:
David A. Nielsen, Kenia M. Velasquez, Elisa Ambrosi, Mark J. Harding, Eduardo Aramayo, Michelle A. Patriquin, Ramiro Salas, Thomas R. Kosten, Humsini Viswanath, Alok Madan, David L. Molfese, B. Christopher Frueh, J. Christopher Fowler, Philip R. Baldwin, Kaylah Curtis
Publikováno v:
The American Journal on Addictions. 26:751-759
Background and objectives Opioid use disorder (OUD) is a chronic disorder with relapse based on both desire for reinforcement (craving) and avoidance of withdrawal. The aversive aspect of dependence and relapse has been associated with a small brain
Autor:
David A. Nielsen, Ellen M. Nielsen, Sara C. Hamon, Catherine J. Spellicy, Thomas R. Kosten, An Ye, June Kampangkaew, Mark J. Harding
Publikováno v:
Am J Addict
Background and objectives Disulfiram has been beneficial in treating cocaine addiction in several studies. Patients with two SLC6A3 (DAT1) rs28363170 10-repeat alleles who have with genetically high dopamine transporter (DAT) levels may benefit from
Autor:
B. Christopher Frueh, Ramiro Salas, Michelle A. Patriquin, Mark J. Harding, Huiqiong Deng, J. Christopher Fowler, John M. Oldham, David A. Nielsen
Publikováno v:
European archives of psychiatry and clinical neuroscience. 270(5)
Variants in three genes coding for components of the serotonergic system, the tryptophan hydroxylase 1 (TPH1) rs1799913, serotonin transporter (SLC6A4) 5-HTTLPR, and serotonin receptor 2A (HTR2A) rs6311, were evaluated for association with suicidal i
Publikováno v:
Behavioural brain research. 356
Mild traumatic brain injury (mTBI) occurred in 15–30% of Veterans returning from Iraq and Afghanistan. We examined whether DNA methylation of the apolipoprotein E (APOE) gene promoter region or plasma ApoE protein levels are altered in mTBI. APOE p